8 completed, 1 terminated. 9 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 8, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Hypogonadotropic Hypogonadism: new trials by email Literature Review of Hypogonadotropic Hypogonadism trials Research Report on Hypogonadotropic Hypogonadism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Opioid Antagonism in Hypogonadotropic Hypogonadism Naloxone - Hypogonadotropic Hypogonadism, Low Testosterone | Phase 1 | Completed | Stephanie B. Seminara, MD | 23 | 2025-06-18 | 2026-06-03 |
| Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders Kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 1 | Completed | Stephanie B. Seminara, MD | 13 | 2022-12-16 | 2025-10-03 |
| Effect of Intranasal Insulin on LH Concentrations in Man intranasal insulin, placebo (intranasal saline) - Hypogonadotropic Hypogonadism | Phase 1 / Phase 2 | Completed | Texas Tech University Health Sciences Center | 14 | 2014-12-01 | 2019-08-13 |
| Neuropeptides in Human Reproduction Kisspeptin 112-121, Naloxone, GnRH - Hypogonadotropic Hypogonadism | Phase 1 | Completed | Massachusetts General Hospital | 61 | 2014-04-30 | 2024-07-31 |
| Kisspeptin in the Evaluation of Delayed Puberty kisspeptin 112-121, GnRH - Delayed Puberty, Kallmann Syndrome | Phase 1 | Completed | Massachusetts General Hospital | 24 | 2013-06-08 | 2023-10-19 |
| Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism, Healthy Postmenopausal Women | Phase 1 | Completed | Massachusetts General Hospital | 96 | 2011-09-01 | 2022-07-11 |
| Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH) Anastrozole Pill, Testosterone, Placebo Oral Tablet - Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 1 | Terminated | Massachusetts General Hospital | 7 | 2010-05-01 | 2017-04-18 |
| Kisspeptin Administration in the Adult kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 1 | Completed | Massachusetts General Hospital | 256 | 2009-06-23 | 2024-07-31 |
| Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS) gonadotropin releasing hormone (GnRH) - Kallmann Syndrome, Hypogonadotropic Hypogonadism | Phase 1 | Completed | Massachusetts General Hospital | 624 | 1989-04-01 | 2022-07-11 |
Hypogonadism (9) · Kallmann Syndrome (4) · Gonadal Dysgenesis (1) · Hyperprolactinemia (1) · Idiopathic Hypogonadotropic Hypogonadism (1) · Polycystic Ovary Syndrome (1) · Puberty, Delayed (1)
Endocrine System Diseases (9) · Gonadal Disorders (9) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Disorders of Sex Development (5) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Male Urogenital Diseases (5) · Urogenital Abnormalities (5) · Urogenital Diseases (5) · Disorder of Sex Development, 46,XY (4) · Genetic Diseases, Inborn (4) · Adnexal Diseases (1) · Brain Diseases (1) · Central Nervous System Diseases (1)
Gonadotropin-Releasing Hormone (5) · Naloxone (2) · Anastrozole (1) · Testosterone (1)
Massachusetts General Hospital (6) · Stephanie B. Seminara, MD (2) · Texas Tech University Health Sciences Center (1)
United States (9)
Stephanie B Seminara, MD (5) · Stephanie Seminara, MD (2) · Nelly Pitteloud, MD (1) · Sandeep Dhindsa, MD (1)
PMID 29669934, PMID 31132118, PMID 11788640, PMID 12213860, PMID 17761590, PMID 21209029, PMID 2122732, PMID 2502554, PMID 25226293, PMID 28368443, PMID 30515210, PMID 3096182, PMID 3098771, PMID 32034419, PMID 32232399, PMID 3900124, PMID 39965102, PMID 41273106, PMID 42230485, PMID 6767977, PMID 6813732, PMID 9010147, PMID 9174769, PMID 9922906
U54HD028138 (1)