39 completed, 13 recruiting, 11 unknown, 4 not yet recruiting. 16 Phase 3, 13 Not applicable, 9 Phase 4, 5 Phase 2, 2 Early Phase 1.
Follow Puberty, Precocious: new trials by email Literature Review of Puberty, Precocious trials Research Report on Puberty, Precocious
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| (Z)-Endoxifen in Girls With MAS-Associated Peripheral Precocious Puberty (Z)-endoxifen - Precocious Puberty, Gonadotropin-dependent | Phase 2 | Not yet recruiting | Atossa Therapeutics, Inc. | 6 | 2027-03-01 | 2026-10-09 |
| INSL3 as a Biomarker of Pubertal Activation: Role in Evaluating Precocious and Delayed Puberty Precocious Puberty, Central, Delayed Puberty | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 100 | 2026-10-02 | 2026-10-06 | |
| A Study of Leuprorelin 1-Month (4-Week) Formulation in Children With Central Precocious Puberty Leuprorelin - Central Precocious Puberty | Phase 4 | Recruiting | LG Chem | 43 | 2026-08-01 | 2026-07-29 |
| Clinical Study of Traditional Chinese Medicine in the Treatment of Phlegm-dampness Intrinsic Precocious Puberty Sanghe Jianghuo Granules, Placebo - Precocious Puberty | Not applicable | Not yet recruiting | Children's Hospital of Fudan University | 200 | 2026-07-01 | 2026-06-09 |
| Research of Integrated Traditional Chinese and Western Medicine on Precocious Puberty administered "Mulberry and Lotus Leaf Heat-Clearing Granules," with the following drug composition: mulberry leaves, lotus leaves, fresh rehmannia, anemarrhena, scutellaria, atractylodes, etc., 10% drug-containing placebo, for a period of 3 months. - Puberty, Precocious | Early Phase 1 | Withdrawn | Children's Hospital of Fudan University | 2026-05-01 | 2026-07-06 | |
| Clinical Observation of Qingwei Huazhuo Decoction (Product: Jinsaiyu) in Improving Children With Precocious Puberty of Phlegm-Dampness Internal Accumulation Type Qingwei Huazhuo Decoction: Mulberry leaf powder, lotus leaf powder, malt powder, hawthorn powder, Poria cocos powder, gardenia powder, dried tangerine peel powder, licorice powder, momordica grosvenor, diet and exercise education - Precocious Puberty | Not applicable | Terminated | Children's Hospital of Fudan University | 94 | 2026-03-30 | 2026-05-05 |
| Basal LH Threshold for the Diagnosis of Central Precocious Puberty Precocious Puberty, Central | Recruiting | University Hospital, Strasbourg, France | 100 | 2026-03-02 | 2026-10-07 | |
| Hypiend - Multicomponent Behavioral Intervention in Pre-puberal Children (Hypiend-PPC) Multi-Component Behavioral intervention, Information - Precocious Puberty, Central, Executive Dysfunction | Not applicable | Active not recruiting | Sciensano | 700 | 2025-09-15 | 2026-08-03 |
| Spexin and Phoenixin-20 in Girls With Central Precocious Puberty Central Precocious Puberty (CPP), Puberty Disorders | Completed | Kayseri City Hospital | 143 | 2024-12-01 | 2026-01-22 | |
| A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty intradermal needles, Ziyinxiehuo Granules of traditional Chinese Medicine - Precocious Puberty, Treatment | Phase 3 | Recruiting | Children's Hospital of Fudan University | 170 | 2024-09-15 | 2026-03-16 |
| A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial) Debio 4326 - Central Precocious Puberty | Phase 3 | Active not recruiting | Debiopharm International SA | 56 | 2024-07-31 | 2026-10-23 |
| Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP Triptorelin pamoate（15mg）, Triptorelin acetate （3.75mg） - Central Precocious Puberty | Phase 4 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 134 | 2024-07-01 | 2024-07-05 |
| Observation of Environment and Reproductive-Endocrine Effects Hypogonadism, Hypergonadism | Recruiting | National Institute of Environmental Health Sciences (NIEHS) | 300 | 2024-07-01 | 2026-09-28 | |
| First Observatory of Precocious Puberty. Puberty, Precocious | Active not recruiting | Hospices Civils de Lyon | 3360 | 2024-06-26 | 2026-10-27 | |
| Idiopathic Central Precocious Puberty and Associated Neurodevelopmental Syndromes and Pathologies: Evaluation of Frequency and Comparison of Diagnostic and Developmental Characteristics Central Precocious Puberty (CPP) | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 300 | 2024-03-13 | 2026-03-12 | |
| A Study of Medical Records From Children With Central Precocious Puberty (CPP) in China Central Precocious Puberty | Completed | Takeda | 1477 | 2023-12-13 | 2026-01-21 | |
| Danish Precocious Puberty Study - DAPP Study A National Cohort Study on Incidence and Etiologies for Precocious Puberty Metformin Hydrochloride tablet, Placebo, Lifestyle intervention - Puberty, Precocious | Not yet recruiting | Copenhagen University Hospital at Herlev | 1500 | 2023-09-01 | 2023-07-24 | |
| Evaluate the Efficacy and Safety of DWJ108J Leuprolide Acetate 11.25 MG/ML - Central Precocious Puberty | Phase 3 | Unknown | Daewoong Pharmaceutical Co. LTD. | 79 | 2023-08-01 | 2023-09-06 |
| Efficacy, Safety, and Pharmacokinetics of Leuprolide Mesylate in Subjects With Central Precocious Puberty Leuprolide Mesylate, Subcutaneous injection of 42 mg Leuprolide - Puberty; Precocious, Central | Phase 3 | Completed | Foresee Pharmaceuticals Co., Ltd. | 94 | 2023-06-02 | 2026-07-20 |
| Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context Environmental health measures - Puberty, Precocious, Breast | Not applicable | Recruiting | Lille Catholic University | 62 | 2023-05-15 | 2026-03-17 |
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Hypogonadism (5) · Puberty, Delayed (4) · Fibrous Dysplasia, Polyostotic (3) · Kallmann Syndrome (3) · Amenorrhea (2) · Endocrine System Diseases (2) · Familial Testotoxicosis (2) · Infertility (2) · Obesity (2) · Overweight (2) · Rare Diseases (2) · Adrenal Hyperplasia, Congenital (1) · Adrenal Insufficiency (1) · Angelman Syndrome (1)
Gonadal Disorders (73) · Endocrine System Diseases (72) · Pathological Conditions, Signs and Symptoms (8) · Musculoskeletal Diseases (6) · Bone Diseases (5) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Nutritional and Metabolic Diseases (5) · Bone Diseases, Developmental (4) · Disorders of Sex Development (4) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Genetic Diseases, Inborn (4) · Male Urogenital Diseases (4) · Nutrition Disorders (4)
Leuprolide (17) · Triptorelin Pamoate (6) · Gonadotropin-Releasing Hormone (3) · Testolactone (2) · 4-hydroxy-N-desmethyltamoxifen (1) · Anastrozole (1) · Diet (1) · Fulvestrant (1) · Hematologic Tests (1) · Injections (1) · Letrozole (1) · Magnetic Resonance Spectroscopy (1) · Medicine, Chinese Traditional (1) · Metformin (1) · Sodium Chloride (1)
Children's Hospital of Fudan University (6) · Ipsen (4) · Takeda (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3) · Abbott (2) · AstraZeneca (2) · Daewoong Pharmaceutical Co. LTD. (2) · Debiopharm International SA (2) · National Center for Research Resources (NCRR) (2) · National Institute of Environmental Health Sciences (NIEHS) (2) · Shenzhen Center for Disease Control and Prevention (2) · University of Aarhus (2) · AbbVie (1) · AbbVie (prior sponsor, Abbott) (1)
United States (21) · China (16) · France (9) · South Korea (6) · Italy (5) · Denmark (4) · Puerto Rico (4) · Argentina (3) · Chile (3) · Israel (3) · Mexico (3) · Turkey (Türkiye) (3) · Belgium (2) · Canada (2) · Russia (2)
Federico Baronio, MD (2) · Natalie D Shaw, M.D. (2) · Alison Boyce, MD (1) · Amnon Zung, MD (1) · Anders Juul, PhD, DMSc (1) · Ariane Baye, PhD (1) · Barry Albertson (1)
PMID 23643382, PMID 32870266, PMID 12788881, PMID 14573733, PMID 15132858, PMID 15613419, PMID 16382000, PMID 16606836, PMID 16757106, PMID 16764984, PMID 17074994, PMID 17334928, PMID 17959774, PMID 18272894, PMID 19021638, PMID 19567835, PMID 19951508, PMID 20332248, PMID 20484732, PMID 20696889, PMID 21037178, PMID 21163089, PMID 21209029, PMID 21247312, PMID 21700882, PMID 21860633, PMID 22072740, PMID 22319038, PMID 22344198, PMID 22745237, PMID 22773735, PMID 22904181, PMID 22990093, PMID 22999294, PMID 23378218, PMID 23533228, PMID 24295437, PMID 24476074, PMID 24926950, PMID 25394172, PMID 25803268, PMID 26075496, PMID 28334719, PMID 28472487, PMID 30465166, PMID 31132118, PMID 31319416, PMID 32160304, PMID 32185991, PMID 32480405
2005 (2), 2008 (1), M01RR000064 (1)