5 completed, 2 recruiting, 2 terminated, 1 unknown. 10 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 5, Recruiting 2, Terminated 2, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Hypogonadotropic Hypogonadism: new trials by email Literature Review of Hypogonadotropic Hypogonadism trials Research Report on Hypogonadotropic Hypogonadism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 20 | 2025-12-09 | 2026-07-13 |
| Kisspeptin Administration Subcutaneously to Patients With IHH kisspeptin 112-121, leuprolide acetate - Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 36 | 2023-02-03 | 2026-07-13 |
| Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Stephanie B. Seminara, MD | 18 | 2019-05-03 | 2026-08-26 |
| A 6 Month Safety Extension Study of MBGS205 BGS649 - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Mereo BioPharma | 143 | 2016-11-15 | 2023-05-18 |
| Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism BGS649, Placebo - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Mereo BioPharma | 271 | 2016-05-12 | 2022-09-14 |
| A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism TAK-448 - Hypogonadotropic Hypogonadism | Phase 2 | Terminated | Takeda | 15 | 2015-02-01 | 2017-03-31 |
| Effect of Intranasal Insulin on LH Concentrations in Man intranasal insulin, placebo (intranasal saline) - Hypogonadotropic Hypogonadism | Phase 1 / Phase 2 | Completed | Texas Tech University Health Sciences Center | 14 | 2014-12-01 | 2019-08-13 |
| Hypogonadism in Young Men With Type 2 Diabetes testosterone, clomiphene, placebo - Hypogonadotropic Hypogonadism, Type 2 Diabetes | Phase 2 | Terminated | State University of New York at Buffalo | 5 | 2010-06-01 | 2019-10-04 |
| Clomiphene in Males With Prolactinomas and Persistent Hypogonadism Clomiphene citrate - Hypogonadotropic Hypogonadism, Prolactinoma | Phase 2 | Completed | Federal University of São Paulo | 15 | 2004-06-01 | 2008-06-16 |
| Pulsatile GnRH in Anovulatory Infertility GnRH, Pump - Hypogonadotropic Hypogonadism, Amenorrhea | Phase 2 | Unknown | Massachusetts General Hospital | 270 | 1989-01-01 | 2017-07-12 |
Hypogonadism (10) · Amenorrhea (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Idiopathic Hypogonadotropic Hypogonadism (1) · Infertility (1) · Insulin Resistance (1) · Kallmann Syndrome (1) · Prolactinoma (1)
Endocrine System Diseases (10) · Gonadal Disorders (10) · Adenoma (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Disorder of Sex Development, 46,XY (1) · Disorders of Sex Development (1) · Endocrine Gland Neoplasms (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Genetic Diseases, Inborn (1) · Genital Diseases (1) · Glucose Metabolism Disorders (1)
Clomiphene (2) · Gonadotropin-Releasing Hormone (2) · Leuprolide (1) · Testosterone (1) · leflutrozole (1) · metastin (46-54), acetyl-tyrosyl(46)-hydroxypropyl(47)-threonyl(49)-azaglycyl(51)-methylarginyl(53)-tryptophyl(54)- (1)
Stephanie B. Seminara, MD (3) · Mereo BioPharma (2) · Federal University of São Paulo (1) · Massachusetts General Hospital (1) · State University of New York at Buffalo (1) · Takeda (1) · Texas Tech University Health Sciences Center (1)
United States (8) · United Kingdom (2) · Brazil (1) · Italy (1) · Spain (1)
Hugh Jones (2) · Janet E Hall, M.D. (1) · Julio Abucham, MD, PhD (1) · Sandeep Dhindsa, MBBS (1) · Sandeep Dhindsa, MD (1) · Stephanie Seminara (1) · Stephanie Seminara, MD (1)
PMID 23341491, PMID 30515210, PMID 32034419, PMID 37579053
2014 (1), R37HD043341 (1), U54HD028138 (1)