11 completed, 5 unknown, 3 recruiting, 3 terminated. 5 Phase 1, 4 Not applicable, 3 Phase 4, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 4, Terminated 1 |
| Not applicable | 4 | Completed 2, Unknown 2 |
| Phase 4 | 3 | Unknown 2, Completed 1 |
| Phase 2 | 2 | Terminated 1, Unknown 1 |
Follow Kallmann Syndrome: new trials by email Literature Review of Kallmann Syndrome trials Research Report on Kallmann Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Molecular Basis of Inherited Reproductive Disorders Hypogonadotropic Hypogonadism, Reproductive Disorder | Completed | Stephanie B. Seminara, MD | 854 | 2021-01-21 | 2026-07-13 | |
| Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH) Human Chorionic Gonadotropin, human menopausal gonadotropin - Isolated Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 4 | Unknown | Tongji Hospital | 210 | 2018-10-18 | 2020-04-08 |
| GROWing Up With Rare GENEtic Syndromes Retrospective file studies - Prader-Willi Syndrome, PWS-like Syndrome | Recruiting | dr. Laura C. G. de Graaff-Herder | 600 | 2018-10-01 | 2023-09-06 | |
| Patient and Healthcare Professional Views on Genetic/Genomic Information and Testing Hypogonadism, Hypogonadotropic, Kallmann Syndrome | Active not recruiting | Boston College | 227 | 2018-03-22 | 2025-02-04 | |
| Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Human Menopausal Gonadotropin, Human Chorionic Gonadotropin - Kallmann Syndrome, Hypogonadotropic Hypogonadism | Phase 4 | Unknown | Beijing Children's Hospital | 40 | 2016-08-01 | 2016-08-26 |
| Psychological Outcomes in Isolated GnRH Deficiency Hypogonadism | Terminated | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 48 | 2015-02-04 | 2019-07-18 | |
| Health Needs of Patients With Kallmann Syndrome online questionairres - Kallmann Syndrome, Congenital Hypogonadotropic Hypogonadism | Completed | Centre Hospitalier Universitaire Vaudois | 249 | 2013-07-01 | 2017-09-29 | |
| Kisspeptin in the Evaluation of Delayed Puberty kisspeptin 112-121, GnRH - Delayed Puberty, Kallmann Syndrome | Phase 1 | Completed | Massachusetts General Hospital | 24 | 2013-06-08 | 2023-10-19 |
| Hormonal Regulation of Puberty and Fertility Endocrine Disease, Infertility | Completed | National Institute of Environmental Health Sciences (NIEHS) | 111 | 2012-04-25 | 2026-10-08 | |
| Inherited Reproductive Disorders Genetic Disorder, Infertility | Recruiting | National Institute of Environmental Health Sciences (NIEHS) | 850 | 2012-04-25 | 2026-10-13 | |
| Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate Kallmann Syndrome, Hypogonadotropic Hypogonadism | Recruiting | Centre Hospitalier Universitaire Vaudois | 2000 | 2012-03-01 | 2022-06-21 | |
| Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH) Anastrozole Pill, Testosterone, Placebo Oral Tablet - Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 1 | Terminated | Massachusetts General Hospital | 7 | 2010-05-01 | 2017-04-18 |
| Sequential Therapy for Hypogonadotropic Hypogonadism Traditional intervention for HH using HCG and FSH, Sequential intervention for HH using HCG and FSH, Sequential intervention for HH using HCG and FSH plus zinc - Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 100 | 2009-09-01 | 2014-02-11 |
| Kisspeptin Administration in the Adult kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 1 | Completed | Massachusetts General Hospital | 256 | 2009-06-23 | 2024-07-31 |
| A Study to Characterize Epidemiology, Clinical and Genetic Features of Kallmann Syndrome in Finland Short withdrawal of testosterone, gonadotropins or estrogenic compounds (see below) - Kallmann Syndrome | Not applicable | Unknown | Hospital for Children and Adolescents, Finland | 50 | 2007-12-01 | 2008-02-25 |
| Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men GnRH antagonist (Acyline) - Hypogonadism | Not applicable | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 40 | 2002-10-01 | 2011-04-20 |
| Follicle Stimulating Hormone (FSH) to Improve Testicular Development in Men With Hypogonadism Testicular biopsy, gonadotropin releasing hormone (GnRH), follicle stimulating hormone (FSH) - Hypogonadism, Kallmann Syndrome | Phase 2 | Terminated | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 19 | 2001-04-01 | 2017-07-07 |
| Baselines in Reproductive Disorders Frequent baseline blood sampling - Amenorrhea, Hypogonadotropic Hypogonadism | Not applicable | Unknown | Massachusetts General Hospital | 180 | 1999-09-01 | 2014-08-04 |
| Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders Hypogonadotropic Hypogonadism, Kallmann Syndrome | Completed | Massachusetts General Hospital | 4042 | 1999-01-01 | 2022-06-30 | |
| Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism gonadotropin releasing hormone (GnRH) - Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism | Phase 1 | Completed | Massachusetts General Hospital | 27 | 1999-01-01 | 2022-07-01 |
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Hypogonadism (20) · Idiopathic Hypogonadotropic Hypogonadism (6) · Infertility (5) · Puberty, Delayed (5) · Amenorrhea (4) · Puberty, Precocious (3) · Polycystic Ovary Syndrome (2) · 22q11 Deletion Syndrome (1) · Acrocephalosyndactylia (1) · Adrenal Hyperplasia, Congenital (1) · Allan-Herndon-Dudley syndrome (1) · Anosmia (1) · Bardet-Biedl Syndrome (1) · Blepharophimosis syndrome Ohdo type (1)
Congenital Abnormalities (23) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (23) · Female Urogenital Diseases (23) · Female Urogenital Diseases and Pregnancy Complications (23) · Male Urogenital Diseases (23) · Urogenital Abnormalities (23) · Urogenital Diseases (23) · Disorder of Sex Development, 46,XY (22) · Disorders of Sex Development (22) · Endocrine System Diseases (22) · Genetic Diseases, Inborn (22) · Gonadal Disorders (22) · Pathological Conditions, Signs and Symptoms (7) · Genital Diseases (6) · Pathologic Processes (5)
Gonadotropin-Releasing Hormone (7) · Chorionic Gonadotropin (2) · Menotropins (2) · Anastrozole (1) · Estrogens (1) · Follicle Stimulating Hormone (1) · Gonadotropins (1) · Ketoconazole (1) · Testosterone (1) · Zinc (1) · acyline (1) · follitropin alfa (1)
Massachusetts General Hospital (8) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · Centre Hospitalier Universitaire Vaudois (2) · National Institute of Environmental Health Sciences (NIEHS) (2) · Beijing Children's Hospital (1) · Boston College (1) · Hospital for Children and Adolescents, Finland (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Shanghai Jiao Tong University School of Medicine (1) · Stephanie B. Seminara, MD (1) · Tongji Hospital (1) · dr. Laura C. G. de Graaff-Herder (1)
United States (16) · China (3) · Switzerland (2) · Finland (1) · Netherlands (1)
Stephanie B Seminara, MD (4) · Janet E Hall, M.D. (2) · Natalie D Shaw, M.D. (2) · William F Crowley, Jr., MD (2) · Andrew A Dwyer, PhD (1) · Andrew Dwyer, PhD, FNP-BC (1) · Angela Delaney Freedman, M.D. (1) · Chunxiu Gong, doctor (1) · Frances J Hayes, MD (1) · Jihong Liu, M.D (1) · Nelly Pitteloud, M.D. (1) · Nelly Pitteloud, MD (1) · Seminara B Stephanie, MD (1) · Stephanie Seminara, MD (1) · Taneli J Raivio, MD PhD (1)
PMID 32034419, PMID 21209029, PMID 23643382, PMID 31132118, PMID 32870266, PMID 11788640, PMID 12213860, PMID 12788881, PMID 14573733, PMID 15613419, PMID 16606836, PMID 16757106, PMID 16764984, PMID 17074994, PMID 17334928, PMID 17761590, PMID 17959774, PMID 18073301, PMID 18270253, PMID 18272894, PMID 18445673, PMID 19021638, PMID 19567835, PMID 19829004, PMID 20332248, PMID 20382682, PMID 20484732, PMID 20696889, PMID 21037178, PMID 2122732, PMID 21247312, PMID 21700882, PMID 22072740, PMID 22319038, PMID 22745237, PMID 22773735, PMID 23341491, PMID 23378218, PMID 23533228, PMID 24037890, PMID 24476074, PMID 24915927, PMID 2502554, PMID 25226293, PMID 25394172, PMID 25825944, PMID 25844173, PMID 27647266, PMID 28320476, PMID 28698240
U54HD028138 (4), R01HD015788 (1)