6 unknown, 3 completed, 3 recruiting, 1 enrolling by invitation. 5 Not applicable, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Unknown 3, Enrolling by invitation 1, Recruiting 1 |
| Phase 4 | 2 | Recruiting 1, Unknown 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Hypnotics and Sedatives: new trials by email Literature Review of Hypnotics and Sedatives trials Research Report on Hypnotics and Sedatives
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Physical Activity Interventions for Sleep Improvement and Sedative-Hypnotic Reduction in Middle-Aged and Older Adults: Investigating the Role of Sarcopenia resistance training, Relaxation training - Insomnia Chronic, Hypnotics and Sedatives | Not applicable | Enrolling by invitation | Chang Gung Memorial Hospital | 40 | 2026-07-01 | 2026-10-27 |
| Nebulized Ketamine for the Treatment of Major Depressive Disorder nebulized ketamine, nebulized midazolam - Severe Depression, Moderate Depression | Phase 3 | Recruiting | Theresa Jacob, PhD, MPH | 40 | 2024-10-16 | 2026-04-24 |
| Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery Ciprofol, Propofol - Anesthetics, Intravenous, Postoperative Complications | Not applicable | Unknown | Xijing Hospital | 280 | 2023-05-16 | 2024-04-09 |
| Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy PARTNER intervention, Control intervention - Deprescriptions, Antidepressive Agents | Not applicable | Recruiting | Ludwig-Maximilians - University of Munich | 352 | 2023-03-25 | 2025-05-04 |
| Bispectral Index and Patient State Index During General Anesthesia With Remimazolam Bispectral index and Patient state index monitoring - Remimazolam, Anesthesia, General | Unknown | Seoul National University Hospital | 40 | 2022-07-01 | 2022-07-01 | |
| Dexmedetomidine for Analgosedation to Newborn Infants During Neonatal Intensive Care dexmedetomidine - Intensive Care, Neonatal, Analgesia | Withdrawn | Region Skane | 2021-06-01 | 2024-07-01 | ||
| Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea Drug-induced sleep endoscopy, Natural sleep endoscopy - Sleep Apnea, Obstructive, Sleep Apnea | Not applicable | Unknown | ethisch.comite@uza.be | 40 | 2021-03-30 | 2021-07-26 |
| Monitoring and Risk Prediction of Iatrogenic Sedative Hypnotics Addiction in a Shanghai Psychiatric Hospital Hypnotics and Sedatives, Addiction | Unknown | Shanghai Mental Health Center | 100000 | 2020-08-01 | 2020-08-07 | |
| Evaluation of Sedation in COVID-19 ARDS Treatment group - Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2 | Completed | Goethe University | 114 | 2020-03-01 | 2021-07-01 | |
| Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients Dexmedetomidine Hydrochloride Group - Delirium, Cognitive Dysfunction | Phase 4 | Recruiting | Sunnybrook Health Sciences Centre | 2400 | 2019-12-01 | 2025-12-01 |
| Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection Dexmedetomidine - Delirium, Postoperative Complications | Phase 4 | Unknown | Second Affiliated Hospital of Wenzhou Medical University | 42 | 2018-05-23 | 2019-09-25 |
| Clonidine for Analgesia to Preterm Infants During Neonatal Intensive Care Clonidine - Intensive Care, Neonatal, Analgesia | Completed | Region Skane | 40 | 2018-04-06 | 2023-08-04 | |
| Generalized Versus Personalized Music Therapy in the ICU to Reduce Sedation Generalized Music therapy, Personalized Music therapy - Critical Illness, Hypnotics and Sedatives | Not applicable | Unknown | University of Milan | 153 | 2017-05-01 | 2018-06-26 |
| Longitudinal Analysis of Drug Burden Index Polypharmacy, Anticholinergics | Completed | University of Groningen | 9985 | 2016-06-01 | 2017-01-19 |
Agnosia (2) · Delirium (2) · Mental Disorders (2) · Nervous System Diseases (2) · Neurocognitive Disorders (2) · Postoperative Complications (2) · Apnea (1) · Behavior, Addictive (1) · Breast Diseases (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Confusion (1) · Critical Illness (1) · Depression (1) · Dyssomnias (1)
Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Nervous System Diseases (4) · Behavior (3) · Neurobehavioral Manifestations (3) · Mental Disorders (2) · Pathologic Processes (2) · Perceptual Disorders (2) · Atrophy (1) · Behavioral Symptoms (1) · Compulsive Behavior (1) · Confusion (1) · Disease Attributes (1) · Dyssomnias (1)
Dexmedetomidine (3) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Clonidine (1) · HSK3486 (1) · Ketamine (1) · Midazolam (1) · Propofol (1) · Relaxation Therapy (1) · Resistance Training (1)
Region Skane (2) · Chang Gung Memorial Hospital (1) · Goethe University (1) · Ludwig-Maximilians - University of Munich (1) · Second Affiliated Hospital of Wenzhou Medical University (1) · Seoul National University Hospital (1) · Shanghai Mental Health Center (1) · Sunnybrook Health Sciences Centre (1) · Theresa Jacob, PhD, MPH (1) · University of Groningen (1) · University of Milan (1) · Xijing Hospital (1) · ethisch.comite@uza.be (1)
China (2) · Germany (2) · Sweden (2) · Belgium (1) · Canada (1) · Italy (1) · South Korea (1) · Taiwan (1) · United States (1)
Elisabeth Norman, MD (2) · Armin N Flinspach, MD (1) · Haopeng Zhang (1) · Hee-Soo Kim, MD,PhD (1) · Jun Li (1) · Olivier Vanderveken, MD, PhD (1) · Stephen Choi, MD,MSc,FRCPC (1) · Theresa Jacob, PhD, MPH (1) · Tobias Dreischulte, Prof. Dr. (1)
PMID 33849856, PMID 34950101, PMID 38867317, PMID 41522713
2015 (1), 2017 (1)