20 completed, 9 unknown, 3 not yet recruiting, 2 withdrawn. 35 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 35 | Completed 20, Unknown 9, Not yet recruiting 3, Withdrawn 2, Suspended 1 |
Follow Hypertriglyceridemia: new trials by email Literature Review of Hypertriglyceridemia trials Research Report on Hypertriglyceridemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular Disease Dose adjustment of statins, no dose adjustment - Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA | Phase 4 | Not yet recruiting | Rehman Medical Institute - RMI | 178 | 2026-11-01 | 2026-11-05 |
| GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis Semaglutide, Placebo (Normal Saline) - Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 396 | 2026-09-01 | 2026-06-01 |
| Icosapent Ethyl for High-Risk Coronary Plaques Assessed by 18F-NaF PET/CT icosapent ethyl (IPE), Standard LDL-C-Lowering Therapy - Coronary Artery Disease, Hyperlipidaemia | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 100 | 2026-08-01 | 2026-08-13 |
| Study of the Efficacy and Safety of EPA in Patients With Type-2 Diabetes EPAVasc, Corn Oil - Diabetes Type 2, Hypertriglyceridemia | Phase 4 | Unknown | University of Ioannina | 450 | 2023-12-01 | 2023-11-15 |
| Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis insulin, standard treatment - Hypertriglyceridemia, Acute Pancreatitis | Phase 4 | Unknown | University Medical Centre Ljubljana | 30 | 2022-11-01 | 2022-11-01 |
| The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk Icosapent Ethyl 1000 MG Oral Capsule [Vascepa] - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 4 | Completed | Canadian Medical and Surgical Knowledge Translation Research Group | 70 | 2020-09-24 | 2024-04-02 |
| Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. Insulin, plasmapheresis - Acute Pancreatitis, Hypertriglyceridemia | Phase 4 | Unknown | First Affiliated Hospital of Wenzhou Medical University | 200 | 2018-06-06 | 2018-06-06 |
| Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Insulin, Aphesis - Pancreatitis, Acute, Hypertriglyceridemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 220 | 2017-11-01 | 2017-11-17 |
| The Effect of Omega-3 FA on Hypertriglyceridemia in Patients With T2DM(OCEAN) Omega-3 fatty acid, Placebos - Type 2 Diabetes Mellitus, Hypertriglyceridemia | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 309 | 2017-05-01 | 2023-10-30 |
| Effect of Vascepa on Improving Coronary Atherosclerosis in People With High Triglycerides Taking Statin Therapy Vascepa, placebo - Hypertriglyceridemia | Phase 4 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 80 | 2017-03-28 | 2023-02-21 |
| Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary Syndrome Fenofibrate, Simvastatin - Acute Coronary Syndrome, Diabetes Mellitus, Type 2 | Phase 4 | Unknown | Koval' O., MD | 60 | 2014-01-01 | 2016-08-04 |
| Lovaza Mechanisms of Action Omega 3 fatty acid (Lovaza) - Moderate Hypertriglyceridemia. | Phase 4 | Unknown | Brigham and Women's Hospital | 40 | 2012-08-01 | 2013-02-25 |
| Vascular and Metabolic Effects of Fenofibrate/Omega vs Fenofibrate placebo, fenofibrate/omega, fenofibrate - Hypertriglyceridemia | Phase 4 | Completed | Gachon University Gil Medical Center | 120 | 2012-01-01 | 2014-11-04 |
| Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma oral glucose tolerance test (OGTT) - Hypertriglyceridemia, Cutaneous T Cell Lymphoma | Phase 4 | Completed | Rennes University Hospital | 10 | 2012-01-01 | 2017-07-21 |
| Effects of DPP-4 Inhibition on Triglycerides Saxagliptin - Type 2 Diabetes, Hypertriglyceridemia | Phase 4 | Suspended | Oregon Health and Science University | 15 | 2012-01-01 | 2023-04-07 |
| A Study to Evaluate Fenofibrate Combination With Statin in Chinese Patients With Dyslipidemic fenofibrate - Dyslipidemias, Cardiovascular Diseases | Phase 4 | Completed | Abbott | 506 | 2011-10-01 | 2015-03-17 |
| Fish Oil Supplementation and Vascular Function in Hypertensive Patients With Hypertriglyceridemia DHA-EPA, Ciprofibrate - Hypertension, Hypertriglyceridemia | Phase 4 | Unknown | Hospital Universitario Pedro Ernesto | 52 | 2011-05-01 | 2011-11-29 |
| Vascular and Metabolic Effects of Omega-3 Fatty Acids placebo, omega - Hypertriglyceridemia | Phase 4 | Completed | Gachon University Gil Medical Center | 176 | 2011-03-01 | 2014-11-04 |
| Effects of Lovaza on High Density Lipoprotein (HDL) Composition and Function in Hypertriglyceridemia Lovaza (Omega-3 acid ethyl esters), Placebo - Hypertriglyceridemia | Phase 4 | Withdrawn | University of Utah | 2010-08-01 | 2016-02-08 | |
| Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) in Metabolic Syndrome Saffron tablet, Barberry tablet, Placebo - Metabolic Syndrome, Hypercholesterolemia | Phase 4 | Completed | Birjand University of Medical Sciences | 732 | 2010-01-01 | 2012-06-21 |
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Insulin Resistance (8) · Diabetes Mellitus, Type 2 (6) · Hypercholesterolemia (5) · Dyslipidemias (4) · Pancreatitis (4) · Cardiovascular Diseases (3) · Coronary Artery Disease (2) · Diabetes Mellitus (2) · HIV Infections (2) · Hyperlipidemias (2) · Hyperlipoproteinemia Type IV (2) · Inflammation (2) · Metabolic Syndrome (2) · Acquired Immunodeficiency Syndrome (1)
Metabolic Diseases (35) · Nutritional and Metabolic Diseases (35) · Lipid Metabolism Disorders (34) · Hyperlipidemias (33) · Dyslipidemias (31) · Glucose Metabolism Disorders (15) · Hyperinsulinism (9) · Endocrine System Diseases (7) · Cardiovascular Diseases (5) · Diabetes Mellitus (5) · Vascular Diseases (5) · Digestive System Diseases (4) · Pancreatic Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Heart Diseases (3)
Omacor (10) · Fenofibrate (8) · Fatty Acids, Omega-3 (3) · Insulin (3) · eicosapentaenoic acid ethyl ester (3) · Atorvastatin (1) · Combined Modality Therapy (1) · Corn Oil (1) · Dialysis Solutions (1) · Fatty Acids (1) · Glucose Tolerance Test (1) · Icodextrin (1) · Niacin (1) · Plasmapheresis (1) · Ritonavir (1)
Gachon University Gil Medical Center (4) · GlaxoSmithKline (2) · Peking Union Medical College Hospital (2) · Abbott (1) · AstraZeneca (1) · Birjand University of Medical Sciences (1) · Brigham and Women's Hospital (1) · Brown, Todd, M.D., Ph.D. (1) · Canadian Medical and Surgical Knowledge Translation Research Group (1) · China National Center for Cardiovascular Diseases (1) · Eastern Virginia Medical School (1) · Enzymotec (1) · Felizarta, Franco, M.D. (1) · First Affiliated Hospital of Wenzhou Medical University (1) · Hospital Universitario Pedro Ernesto (1)
United States (12) · South Korea (5) · China (4) · Brazil (1) · Canada (1) · France (1) · Greece (1) · Iran (1) · Israel (1) · Mexico (1) · Pakistan (1) · Ukraine (1)
Aaron I Vinik, MD, PhD (1) · Adrian S Dobs, MD (1) · Ana Polanco, MD (1) · Charles Glueck, MD (1) · David A Hess, PhD (1) · David Leaf, MD (1) · Deepak L Bhatt, MD, MPH (1) · Dick C Chan, PhD (1) · Dror Harats, M.D. (1) · Eliot A Brinton, MD (1) · Fernanda J Medeiros, PhD (1) · Franco Felizarta, MD (1)
PMID 19116237, PMID 19597368, PMID 19651918, PMID 19820283, PMID 20617456, PMID 20888102, PMID 22892157, PMID 23323877, PMID 23683266, PMID 25932792, PMID 31103643, PMID 31215460, PMID 36877807, PMID 38310429, PMID 38552629, PMID 38965031, PMID 39163858, PMID 41824590
K23AT002862 (1), R01DK061486 (1)