225 completed, 29 unknown, 18 recruiting, 18 terminated. 96 Not applicable, 81 Phase 2, 62 Phase 3, 40 Phase 1, 35 Phase 4.
Follow Hypertriglyceridemia: new trials by email Literature Review of Hypertriglyceridemia trials Research Report on Hypertriglyceridemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic Hyperlipidemia High fat liquid shake - Lipid Metabolism Disorders | Not applicable | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 48 | 2026-11-11 | 2026-11-06 |
| Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular Disease Dose adjustment of statins, no dose adjustment - Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA | Phase 4 | Not yet recruiting | Rehman Medical Institute - RMI | 178 | 2026-11-01 | 2026-11-05 |
| A Phase 2 Study to Evaluate the Efficacy and Safety of DR10624 in Subjects With Moderate Hypertriglyceridemia and Diabetic Kidney Disease DR10624 Injection, Placebo - Hypertriglyceridemia | Phase 2 | Not yet recruiting | Zhejiang Doer Biologics Co., Ltd. | 315 | 2026-10-01 | 2026-09-30 |
| Comparing Two Low-Carbohydrate Diets With a Standard Diet in Type 2 Diabetes High-Protein Low-Carbohydrate Diet, High-Fat Low-Carbohydrate Diet, Standard diet - Diabete Mellitus, Obesity & Overweight | Not applicable | Not yet recruiting | National Nutrition and Food Technology Institute | 168 | 2026-09-20 | 2026-09-08 |
| Standardized Large Yellow Tea Extract for Glucose and Lipid Metabolism in Overweight Adults With Hypertriglyceridemia Standardized Large Yellow Tea Extract, Placebo - Hypertriglyceridemia, Overweight , Obesity | Not applicable | Not yet recruiting | The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial) | 138 | 2026-09-01 | 2026-09-25 |
| GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis Semaglutide, Placebo (Normal Saline) - Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 396 | 2026-09-01 | 2026-06-01 |
| A Phase III Study to Evaluate the Efficacy and Safety of of DR10624 in Subjects With Severe Hypertriglyceridemia DR10624 Injection, Matching Placebo for DR10624 - Severe Hypertriglyceridemia (sHTG), Hypertriglyceridemia | Phase 3 | Not yet recruiting | Zhejiang Doer Biologics Co., Ltd. | 480 | 2026-08-17 | 2026-07-10 |
| Icosapent Ethyl for High-Risk Coronary Plaques Assessed by 18F-NaF PET/CT icosapent ethyl (IPE), Standard LDL-C-Lowering Therapy - Coronary Artery Disease, Hyperlipidaemia | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 100 | 2026-08-01 | 2026-08-13 |
| A Phase 3 Trial of DR10624 Versus Placebo in Patients With Severe Hypertriglyceridemia DR10624 Subcutaneous Injection, Icosapent Ethyl Oral Capsule, Matching Placebo Subcutaneous Injection - Severe Hypertriglyceridemia | Phase 3 | Not yet recruiting | Zhejiang Doer Biologics Co., Ltd. | 378 | 2026-08-01 | 2026-07-06 |
| Cardiovascular-Kidney-Metabolic Syndrome Registry Cardiovascular Kidney Metabolic Syndrome | Not yet recruiting | Centre for Chronic Disease Control, India | 2250 | 2026-07-24 | 2026-07-22 | |
| CS-121 APOC3 Base Editing in Severe Hypertriglyceridemia CS-121 - Severe Hypertriglyceridemia (sHTG) | Early Phase 1 | Not yet recruiting | CorrectSequence Therapeutics Co., Ltd | 15 | 2026-06-15 | 2026-06-18 |
| Pemafibrate for Symptomatic ICAS RCT Pemafibrate - Intracranial Atherosclerotic Disease (ICAD), Hypertriglyceridaemia | Not applicable | Recruiting | Tokyo Women's Medical University | 270 | 2026-05-26 | 2026-11-03 |
| A Study to Assess the Safety, Tolerability and Efficacy of ION775 ION775 - Hypertriglyceridemia, Severe Hypertriglyceridemia | Phase 2 | Recruiting | Ionis Pharmaceuticals, Inc. | 72 | 2026-05-12 | 2026-11-02 |
| A Study of SHR-1918 In Participants With Hypertriglyceridemia SHR-1918/ SHR-1918 placebo - Hypertriglyceridemia | Phase 3 | Active not recruiting | Beijing Suncadia Pharmaceuticals Co., Ltd | 367 | 2026-03-31 | 2026-10-20 |
| First-in-Human Study of ISH0688: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics ISH0688 for injection, Placebo - Healthy Subjects, Hyperlipidemia, Hypertriglyceridemia | Phase 1 | Not yet recruiting | SUNHO（China）BioPharmaceutical CO., Ltd. | 104 | 2026-03-01 | 2026-04-01 |
| RBD5044 in Chinese Participants With Hypertriglyceridemia RBD5044, Placebo - Hypertriglyceridemia | Phase 2 | Active not recruiting | Ribotek Biopharmaceuticals (Shandong) Co., Ltd | 40 | 2026-02-28 | 2026-08-24 |
| WB-EMS Effects on Cardiometabolic Risk Factors WB-EMS, Control - Hypertension, Metabolic Syndrome | Not applicable | Active not recruiting | University of Erlangen-Nürnberg Medical School | 28 | 2026-02-15 | 2026-05-14 |
| Limosilactobacillus Fermentum CRL 1446 - CONICET CASASCO Limosilactobacillus fermentum 1446 CRL CONICET 2.20E+9 CFU, Placebo (inert excipient) - Disbiosis, Obesity | Not applicable | Active not recruiting | PINER Pastor Manfredi Winery | 80 | 2026-02-02 | 2026-05-14 |
| Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition Isocaloric diet including chia and pumpkin seeds, Isocaloric diet - Hypertriglyceridemia | Not applicable | Recruiting | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 375 | 2026-02-01 | 2026-04-14 |
| A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia Solbinsiran, Placebo - Severe Hypertriglyceridemia | Phase 2 | Recruiting | Eli Lilly and Company | 60 | 2025-12-08 | 2026-11-04 |
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Dyslipidemias (45) · Hypercholesterolemia (35) · Hyperlipidemias (32) · Insulin Resistance (28) · Obesity (28) · Metabolic Syndrome (26) · Cardiovascular Diseases (25) · Diabetes Mellitus (24) · Diabetes Mellitus, Type 2 (19) · Hypertension (19) · Lipid Metabolism Disorders (14) · Overweight (13) · Hyperglycemia (11) · Metabolic Diseases (11)
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Omacor (28) · Fenofibrate (26) · eicosapentaenoic acid ethyl ester (15) · Fish Oils (8) · Atorvastatin (6) · Corn Oil (6) · Diet (6) · metreleptin (6) · Fatty Acids, Omega-3 (5) · Niacin (5) · Simvastatin (5) · olezarsen (5) · plozasiran (5) · Docosahexaenoic Acids (4) · Fructose (4)
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