4583 completed, 1032 unknown, 655 recruiting, 389 terminated. 2956 Not applicable, 853 Phase 3, 839 Phase 4, 636 Phase 2, 478 Phase 1.
Follow Hypertension: new trials by email Literature Review of Hypertension trials Research Report on Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin Resistance Vigabatrin Pill, Placebo oral tablet - Hyperinsulinism, Insulin Resistance | Phase 2 | Withdrawn | University of Arizona | 2030-04-15 | 2025-07-30 | |
| Veteran Centered Meal Intervention in Chronic Kidney Disease Medically tailored meals (MTMs) - Chronic Kidney Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 100 | 2027-10-01 | 2026-09-03 |
| Mobile Health Management of Hypertension mHealth Coaching Intervention, Enhanced Usual Care - Hypertension | Not applicable | Not yet recruiting | University of Chicago | 40 | 2027-09-01 | 2026-08-10 |
| Know Your Pressures NYC Virtual Automated Navigator Intervention with Health Education, Usual Care - Glaucoma, Hypertension | Not applicable | Not yet recruiting | Columbia University | 7085 | 2027-07-01 | 2026-08-25 |
| Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation HEARTS implementation strategies, Supply chain strengthening - Hypertension (HTN), Type 2 Diabetes | Not applicable | Not yet recruiting | University of Michigan | 1440 | 2027-05-01 | 2026-04-17 |
| REmote Physical ACtivity Intervention for High Blood Pressure Postpartum Patient Portal Messaging, FitBit EHR Linkage - Hypertension (HTN), Hypertension ,Pregnancy | Not applicable | Not yet recruiting | Northwestern University | 60 | 2027-04-01 | 2026-09-17 |
| Monitoring Blood Pressure at Home and Pharmacy Telehealth Remote Blood Pressure Monitoring + Telehealth - Hypertension, Blood Pressure | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 420 | 2027-04-01 | 2026-06-15 |
| Tracking Income Dynamics and Everyday Health Study Preventative health review invitation early in SNAP cycle, Financial counseling invitation early in the SNAP cycle, Aim 3 follow-up call early in the SNAP period - HIV, Hypertension | Not applicable | Not yet recruiting | University of Pennsylvania | 400 | 2027-03-01 | 2026-10-19 |
| Monitoring Blood Pressure at Home and Pharmacy Telehealth Among People Living With HIV Remote Blood Pressure Monitoring + Telehealth - Hypertension, Blood Pressure Monitoring | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 572 | 2027-02-01 | 2026-09-30 |
| Optimizing Care For Management Of Hard To Control Hypertension In Low-Income Patients Across Family Health Centers In New York City Multilevel Hypertension Care Model - Hypertension | Not applicable | Not yet recruiting | NYU Langone Health | 628 | 2027-02-01 | 2026-07-14 |
| Project HOPE (Hypertension Outreach Through Partnership and Engagement) Project HOPE Intervention - Hypertension (HTN) | Not yet recruiting | Johns Hopkins University | 150 | 2027-02-01 | 2026-09-08 | |
| Antihypertensive Self-titration in US Primary Care Self-Titration - Hypertension | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 30 | 2027-02-01 | 2026-10-13 |
| Fixed-dose Combination of an Angiotensin Receptor Blocker and Thiazide Diuretic for Essential Hypertension N0877, Benicar HCT ® Tablets 40 mg/25 mg - Essential Arterial Hypertension | Phase 3 | Withdrawn | Eurofarma Laboratorios S.A. | 2027-01-30 | 2026-09-22 | |
| No Time to Pause: Physical Activity to Improve Health of Midlife Hispanic Women Physical activity intervention - Elevated Blood Pressure, Perimenopause | Not applicable | Not yet recruiting | The University of Texas Medical Branch, Galveston | 40 | 2027-01-20 | 2025-12-08 |
| Walk Together Efficacy Trial Walk Together, Hypertension education - Hypertension | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 400 | 2027-01-18 | 2026-10-16 |
| Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension Standard medical treatment, Clinical Decision Support Tool - Hypertension, Hypertension (HTN) | Not applicable | Not yet recruiting | The Cleveland Clinic | 168 | 2027-01-01 | 2026-10-07 |
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass Surgery Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and Dyslipemia | Not yet recruiting | Mario Musella MD | 96 | 2027-01-01 | 2026-09-10 | |
| What is the Role of the Exposome in Pulmonary Hypertension Questionnaires, Samples - Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | Not yet recruiting | Poitiers University Hospital | 150 | 2027-01-01 | 2026-07-22 | |
| Inspiratory Muscle Strength Training in Adults With Type 1 Diabetes High-Resistance Inspiratory Muscle Strength Training, Sham Inspiratory Muscle Strength Training - Type 1 Diabetes | Not applicable | Not yet recruiting | Florida State University | 30 | 2027-01-01 | 2026-10-08 |
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Hypertension, Pulmonary (1011) · Diabetes Mellitus (773) · Cardiovascular Diseases (720) · Obesity (549) · Essential Hypertension (467) · Diabetes Mellitus, Type 2 (372) · Dyslipidemias (282) · Heart Diseases (282) · Hypertension, Pregnancy-Induced (261) · Heart Failure (253) · Renal Insufficiency, Chronic (221) · Hyperlipidemias (213) · Motor Activity (208) · Metabolic Syndrome (207)
Vascular Diseases (7379) · Cardiovascular Diseases (6766) · Nutritional and Metabolic Diseases (1819) · Pathological Conditions, Signs and Symptoms (1697) · Metabolic Diseases (1599) · Glucose Metabolism Disorders (1331) · Respiratory Tract Diseases (1310) · Endocrine System Diseases (1255) · Lung Diseases (1139) · Signs and Symptoms (911) · Pathologic Processes (898) · Urogenital Diseases (860) · Female Urogenital Diseases and Pregnancy Complications (817) · Nutrition Disorders (632)
Amlodipine (343) · Hydrochlorothiazide (244) · Valsartan (180) · Telmisartan (169) · Losartan (123) · Exercise (121) · aliskiren (104) · Nebivolol (66) · Metoprolol (64) · Olmesartan Medoxomil (64) · Sildenafil Citrate (63) · Chlorthalidone (61) · Nifedipine (58) · Irbesartan (55) · candesartan cilexetil (54)
National Heart, Lung, and Blood Institute (NHLBI) (178) · Novartis (147) · Boehringer Ingelheim (124) · Boryung Pharmaceutical Co., Ltd (80) · Novartis Pharmaceuticals (77) · Bayer (74) · AstraZeneca (70) · Chong Kun Dang Pharmaceutical (68) · Brigham and Women's Hospital (67) · University of Zurich (58) · Johns Hopkins University (52) · University of Pennsylvania (51) · Duke University (49) · University of Alabama at Birmingham (49) · Takeda (46)
United States (2456) · China (524) · South Korea (445) · Germany (424) · Canada (379) · United Kingdom (334) · France (315) · Italy (269) · Spain (256) · Brazil (249) · Switzerland (202) · Netherlands (196) · Japan (188) · Turkey (Türkiye) (186) · Poland (166)
Silvia Ulrich, Prof. Dr. (17) · Silvia Ulrich, Prof. (15) · Horst Olschewski, MD (13) · Italo Biaggioni, MD (11) · Wanpen Vongpatanasin, MD (10)
PMID 36398903, PMID 32905623, PMID 38682786, PMID 33769555, PMID 33089502, PMID 39526682, PMID 39356039, PMID 32748394, PMID 34164803, PMID 25771069, PMID 33027067, PMID 40013543, PMID 41264372, PMID 42370263, PMID 12493255, PMID 24107737, PMID 26243788, PMID 26354543, PMID 26589907, PMID 27162632, PMID 33107592, PMID 39171639, PMID 39498822, PMID 41903707, PMID 16982941, PMID 17238390, PMID 18806012, PMID 19249414, PMID 20175775, PMID 20573639, PMID 21093036, PMID 21740078, PMID 21869730, PMID 22230384, PMID 22608107, PMID 22880024, PMID 23636237, PMID 23661689, PMID 24210779, PMID 24578332, PMID 24916507, PMID 25527757, PMID 26187183, PMID 27206567, PMID 27263466, PMID 27659698, PMID 27888609, PMID 28859944, PMID 29030456, PMID 29098321
2009 (26), 2018 (26), 2008 (19), 2023 (16), 2025 (14), OT2HL158287 (9), 2016 (8), 2019 (8), 2014 (7), 2017 (7), P50MD017338 (6), R01HL132448 (5), U10HD021385 (5), U10HD027880 (5), U10HD034216 (5)