7 completed, 2 unknown, 1 recruiting, 1 withdrawn. 11 Phase 2, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 7, Unknown 2, Recruiting 1, Withdrawn 1 |
| Phase 3 | 5 | Completed 3, Recruiting 1, Withdrawn 1 |
Follow Hyperparathyroidism, Primary: new trials by email Literature Review of Hyperparathyroidism, Primary trials Research Report on Hyperparathyroidism, Primary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors 18F-FCH, NeuroEXPLORER - Primary Hyperparathyroidism, Parathyroid Cancer | Phase 2 / Phase 3 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 193 | 2026-04-16 | 2026-06-02 |
| 18F-Fluorocholine for the Detection of Parathyroid Adenomas 18F-Fluorocholine, Positron Emission Tomography (PET) - Hyperparathyroidism, Primary | Phase 2 / Phase 3 | Completed | Thomas Hope | 98 | 2016-09-21 | 2021-10-19 |
| Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism eplerenone, amiloride, Placebo - Primary Hyperparathyroidism | Phase 2 / Phase 3 | Completed | Brigham and Women's Hospital | 69 | 2016-01-01 | 2023-05-03 |
| 11C Methionine PET for the Detection of Hyperfunctional Parathyroid Tissues 11C-Methionine PET/CT scanning, 18F-FDG PET/CT scanning, SPECT-CT scanning - Primary Hyperparathyroidism | Phase 2 | Unknown | University of British Columbia | 50 | 2014-05-01 | 2015-09-18 |
| Primary Hyperparathyroidism (PHPT): Early Effect of Vitamin D Placebo, Vitamin D3 - Primary Hyperparathyroidism, Hypercalcemia | Phase 2 / Phase 3 | Withdrawn | Columbia University | 2010-05-01 | 2015-03-05 | |
| Primary Hyperparathyroidism: Does a Systematic Treatment Improve the Calcium and Bone Metabolism After Surgery? Calcium and vitamin D - Primary Hyperparathyroidism, Bone Metabolism | Phase 2 | Unknown | Medical University of Vienna | 80 | 2009-09-01 | 2016-03-16 |
| Effect of Vitamin D Treatment in Primary Hyperparathyroidism Cholecalciferol - Vitamin D Deficiency, Primary Hyperparathyroidism | Phase 2 / Phase 3 | Completed | University of Aarhus | 46 | 2008-05-01 | 2013-11-18 |
| A Multicenter, Open-label Extension Study to Assess the Long-term Safety and Efficacy of an Oral Calcimimetic Agent AMG 073 (Cinacalcet) in Primary Hyperparathyroidism cinacalcet - Hyperparathyroidism, Primary | Phase 2 | Completed | Amgen | 45 | 2000-11-01 | 2013-05-08 |
| Safety, Tolerability, and Clinical Effects of Twice-daily Doses of Cinacalcet (AMG 073) in Adults With Primary Hyperparathyroidism (HPT) Cinacalcet, Placebo - Primary Hyperparathyroidism | Phase 2 | Completed | Amgen | 10 | 2000-06-15 | 2018-12-14 |
| A Study to Assess the Efficacy and Safety of Twice-Daily Dose Regimens of an Oral Calcimimetic Agent AMG 073 (Cinacalcet) in Primary Hyperparathyroidism (PHPT) placebo, cinacalcet - Hyperparathyroidism, Primary | Phase 2 | Completed | Amgen | 78 | 1999-11-01 | 2013-05-08 |
| Safety, Pharmacokinetics, and Clinical Effects of Cinacalcet (AMG 073) in Primary Hyperparathyroidism Cinacalcet, Placebo - Primary Hyperparathyroidism | Phase 2 | Completed | Amgen | 48 | 1998-09-29 | 2018-12-13 |
Hypercalcemia (2) · Vitamin D Deficiency (2) · Bone Diseases, Metabolic (1) · Multiple Endocrine Neoplasia Type 1 (1) · Osteoporosis (1) · Parathyroid Neoplasms (1)
Endocrine System Diseases (11) · Hyperparathyroidism (11) · Parathyroid Diseases (11) · Avitaminosis (2) · Calcium Metabolism Disorders (2) · Deficiency Diseases (2) · Malnutrition (2) · Metabolic Diseases (2) · Nutrition Disorders (2) · Nutritional and Metabolic Diseases (2) · Water-Electrolyte Imbalance (2) · Bone Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Endocrine Gland Neoplasms (1) · Genetic Diseases, Inborn (1)
Cinacalcet (5) · Cholecalciferol (2) · Vitamin D (2) · fluorocholine (2) · Amiloride (1) · Calcium (1) · Eplerenone (1) · Magnetic Resonance Spectroscopy (1) · carbon-11 methionine (1)
Amgen (4) · Brigham and Women's Hospital (1) · Columbia University (1) · Medical University of Vienna (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Thomas Hope (1) · University of Aarhus (1) · University of British Columbia (1)
United States (4) · Austria (1) · Canada (1) · Denmark (1)
Anand Vaidya, MD MMSc (1) · Bruno Niederle, Prof., MD (1) · Don Wilson, MD, FRCPC (1) · Donald W Anderson, MD, FRCSC (1) · Lars Rejnmark, MD,PhD,DrMed (1) · Lars Rolighed, MD (1) · Shonni J. Silverberg, MD (1) · Smita Jha, M.D. (1) · Thomas Hope, MD (1)
PMID 15522938, PMID 19837909, PMID 20943783, PMID 35018442
R01DK084986 (1)