8 completed, 4 recruiting, 1 available, 1 terminated. 5 Phase 2, 4 Phase 3, 3 Phase 1, 2 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Recruiting 1, Terminated 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 3 | Recruiting 2, Completed 1 |
| Early Phase 1 | 2 | Completed 1, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Imaging of Solid Tumors Using DLL3 SPECT 111In-ABD147, Single-photon emission computed tomography (SPECT)/Computerized tomography (CT) - Solid Tumor Cancer, Castration Resistant Prostate Cancer | Early Phase 1 | Withdrawn | Thomas Hope | 2026-04-30 | 2026-04-29 | |
| Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer Iodine-124, Positron Emission Tomography (PET)/Computerized tomography (CT) - Thyroid Cancer | Phase 2 | Recruiting | Thomas Hope | 62 | 2025-12-04 | 2026-06-18 |
| Comparison of 177Lu-PSMA-617 and 225Ac-PSMA-617 177 Lutetium Prostate-Specific Membrane Antigen 617, Actinium-225 Prostate-Specific Membrane Antigen 617, Non-investigational, Prostatectomy - Prostate Cancer, Prostate Cancer (Diagnosis) | Phase 1 | Recruiting | Thomas Hope | 45 | 2025-07-08 | 2026-08-28 |
| Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm Fluorethyltyrosine (18-F), Positron Emission Tomography (PET) - Intracranial Neoplasm | Recruiting | Thomas Hope | 199 | 2024-06-21 | 2026-08-27 | |
| Imaging of Pathologic Fibrosis Using 68Ga-FAP-2286 68Ga-FAP-2286, Positron Emission Tomography (PET) - Liver Fibrosis, Pulmonary Fibrosis | Phase 1 | Completed | Thomas Hope | 16 | 2021-12-09 | 2025-03-21 |
| 68Ga-PSMA-11 PET for the Diagnosis of Metastatic Castration Resistant Prostate Cancer 68Ga-PSMA-11, Positron Emission Tomography (PET) - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 2 | Terminated | Thomas Hope | 15 | 2021-09-28 | 2026-05-15 |
| 18F-Fluorocholine Positron Emission Tomography (PET) for the Detection of Parathyroid Adenomas 18F-Fluorocholine, Positron emission tomography (PET) - Hyperparathyroidism, Primary | Phase 3 | Completed | Thomas Hope | 139 | 2021-06-30 | 2026-04-29 |
| Imaging of Solid Tumors Using FAP-2286 Gallium-68 labelled (68Ga-) FAP-2286, Positron Emission Tomography (PET) imaging, Copper-64 labeled (64Cu-) FAP-2286 - Solid Tumors, Adult, Metastatic Cancer | Phase 1 | Recruiting | Thomas Hope | 191 | 2020-12-14 | 2026-06-04 |
| Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms F-18 Fluoroethyltyrosine (FET), Positron Emission Tomography (PET) - Intracranial Neoplasm, Low Grade Glioma | Phase 2 | Completed | Thomas Hope | 143 | 2018-10-29 | 2026-03-11 |
| Gallium-68 PSMA-11 PET Imaging in Prostate Cancer Patients Ga-68 labeled PSMA-11, Positron emission tomography-computed tomography (PET/CT), Positron emission tomography-magnetic resonance imaging (PET/MRI) - Prostate Cancer | Phase 3 | Completed | Thomas Hope | 485 | 2018-10-11 | 2021-08-24 |
| Gallium-68 PSMA-11 Positron Emission Tomography (PET) Imaging in Patients With Biochemical Recurrence Ga-68 labeled PSMA-11 PET - Prostate Cancer | Phase 3 | Completed | Thomas Hope | 346 | 2017-09-20 | 2021-10-21 |
| Yttrium-90 DOTA-TOC Intra-arterial (IA) Peptide Receptor Radionuclide Therapy (PRRT) for Neuroendocrine Tumor 90Y-DOTA-TOC, 68Ga-DOTA-TOC - Neuroendocrine Tumor | Early Phase 1 | Completed | Thomas Hope | 10 | 2017-07-01 | 2020-07-07 |
| 18F-Fluorocholine for the Detection of Parathyroid Adenomas 18F-Fluorocholine, Positron Emission Tomography (PET) - Hyperparathyroidism, Primary | Phase 2 / Phase 3 | Completed | Thomas Hope | 98 | 2016-09-21 | 2021-10-19 |
| Evaluation of Gallium-68-HBED-CC-PSMA Imaging in Prostate Cancer Patients Ga-68 labeled HBED-CC PSMA, Positron Emission Tomography (PET) image combined with Computed Tomography (CT) (PET/CT), Positron Emission Tomography (PET) image combined with Magnetic Resonance Imaging (MRI) (PET/MRI) - Prostate Cancer | Phase 2 | Completed | Thomas Hope | 225 | 2015-12-18 | 2020-12-22 |
| Expanded Access:18F-Fluorocholine for the Detection of Parathyroid Adenomas 18F-Fluorocholine (FCH), Positron emission tomography (PET) - Parathyroid Adenomas | Available | Thomas Hope | 2025-10-20 |
Prostatic Neoplasms (5) · Brain Neoplasms (2) · Hyperparathyroidism, Primary (2) · Disease (1) · Glioblastoma (1) · Liver Cirrhosis (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Neuroendocrine Tumors (1) · Parathyroid Neoplasms (1) · Pulmonary Fibrosis (1) · Thyroid Neoplasms (1)
Magnetic Resonance Spectroscopy (9) · gallium 68 PSMA-11 (4) · fluorocholine (3) · (18F)fluoroethyltyrosine (2) · Positron Emission Tomography Computed Tomography (2) · (225)Ac-PSMA-617 (1) · 90Y-octreotide, DOTA-Tyr(3)- (1) · Blood Specimen Collection (1) · Fluorine-18 (1) · Ga(III)-DOTATOC (1) · Immunoconjugates (1) · Iodine-124 (1) · Magnetic Resonance Imaging (1) · O-(2-fluoroethyl)tyrosine (1) · Pluvicto (1)
United States (13)
Thomas A Hope, MD (4) · Ivan A de Kouchovsky, MD (1) · Michael Thomas, MD (1)
PMID 28522741, PMID 30920593, PMID 31039025, PMID 32808077, PMID 34529005, PMID 37482512, PMID 38697672