93 completed, 20 unknown, 12 terminated, 6 recruiting. 138 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 138 | Completed 93, Unknown 20, Terminated 12, Recruiting 6, Active not recruiting 2, Not yet recruiting 2, Withdrawn 2, Enrolling by invitation 1 |
Follow Hyperglycemia: new trials by email Literature Review of Hyperglycemia trials Research Report on Hyperglycemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE) Mazdutide, Placebo, Standardized Lifestyle Intervention - Prediabetes, Impaired Fasting Glucose | Phase 4 | Not yet recruiting | Shandong Provincial Hospital | 150 | 2026-07-01 | 2026-06-17 |
| Effect of Add-on SGLT2i, TZD, or Combination Therapy in Type 2 Diabetes Patients on DPP4 Inhibitors Sitagliptin 100 mg, Sitagliptin 100 mg + Dapagliflozin 10 mg, Sitagliptin 100 mg + Dapagliflozin 10 mg + Lobeglitazone 0.5 mg - Diabetes Mellitus, Type 2, Hyperglycemia | Phase 4 | Not yet recruiting | Yonsei University | 100 | 2025-09-01 | 2025-08-07 |
| Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. Metformin, Dulaglutide, Semaglutide 1.0 mg - Diabetes Mellitus Type 2 | Phase 4 | Completed | Fundación para la Investigación del Hospital Clínico de Valencia | 92 | 2025-05-26 | 2026-09-04 |
| Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies - Shock, Preterm Birth Complication | Phase 4 | Active not recruiting | Coordinación de Investigación en Salud, Mexico | 76 | 2025-02-01 | 2025-11-25 |
| Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide Insulin resistance testing, OGTT, Fat biopsy - Diabetes Mellitus, Type 2, Diabetes | Phase 4 | Recruiting | Stanford University | 104 | 2025-01-13 | 2026-04-20 |
| Semaglutide Treatment for Hyperglycaemia After Renal Transplantation Semaglutide 14 MG [Rybelsus], Placebo - Hyperglycemia, Renal Transplant Complication Primary Non-Function | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 104 | 2024-09-19 | 2025-12-29 |
| Metformin Use in Patients Undergoing Total Joint Replacement Surgery Metformin, Placebo - Hyperglycemia | Phase 4 | Completed | Oregon Health and Science University | 40 | 2024-06-27 | 2025-12-05 |
| Effect of Zinc on Glucose Homeostasis Zinc Gluconate 30 MG, Placebo - Prediabetic State, Hyperglycemia | Phase 4 | Recruiting | University of Maryland, Baltimore | 200 | 2024-02-16 | 2026-07-10 |
| Efficacy of Henagliflozin for Weight Loss in Obesity Without Diabetes Henagliflozin, Placebo - Obese, Weight Loss | Phase 4 | Unknown | The First People's Hospital of Changzhou | 300 | 2024-02-15 | 2024-01-22 |
| Effects of Dapagliflozin on Inflammatory Factorslevel and Prognosis in Type 2 Diabetes With Acute Myocardial Infarction Dapagliflozin 10mg/Tab, control group - Myocardial Infarction, Diabete Type 2 | Phase 4 | Completed | Qingdao Central Hospital | 143 | 2023-05-08 | 2026-01-05 |
| Comparison of Low-Intensity Statin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus (PROVE-DM) high-intensity statin arm, low-intensity statin plus ezetimibe - Pre Diabetes, ASCVD | Phase 4 | Enrolling by invitation | Seung-Whan Lee, M.D., Ph.D. | 4000 | 2023-03-14 | 2026-01-07 |
| Treatment to Regress to Normoglycemia in Women with a Recent History of GDM Semaglutide Pen Injector [Ozempic], Placebo semaglutide pen injector - Pre Diabetes, Postpartum Disorder | Phase 4 | Recruiting | Woman's | 102 | 2022-01-13 | 2025-03-13 |
| The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics Mirabegron 50 MG, Tadalafil 10 MG, Placebo - Pre-diabetes, Obesity | Phase 4 | Recruiting | Philip Kern | 96 | 2021-12-13 | 2026-08-31 |
| Insulin for Hyperglycemia in Stroke Trial Analog Insulin, Human insulin - Hyperglycemia, Stroke, Acute | Phase 4 | Completed | National Institute of Neurosciences and Hospital, Dhaka | 452 | 2021-04-05 | 2021-12-06 |
| Effect of Sea Weed (Ecklonia Cava Extract) on Blood Glucose and Insulin Level on Pre-diabetic Patients brown seaweed (ecklonia cava) - PreDiabetes | Phase 4 | Unknown | King Saud University | 30 | 2021-03-01 | 2021-08-20 |
| Oral Anti Diabetic Agents in the Hospital Oral Anti-diabetes Drugs alone, Basal bolus insulin, Supplemental insulin - Diabetes Mellitus | Phase 4 | Terminated | Emory University | 85 | 2020-08-07 | 2026-08-31 |
| GLP-1 Therapy: The Role of IL-6 Signaling and Adipose Tissue Remodeling in Metabolic Response Cyanocobalamin, Dulaglutide - Glucose Intolerance, Overweight and Obesity | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 23 | 2020-05-15 | 2024-12-05 |
| The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans Sacubitril-Valsartan Tab 97-103 MG, Valsartan 160mg, Placebo Oral Tablet - PreDiabetes, Impaired Glucose Tolerance | Phase 4 | Active not recruiting | Ohio State University | 90 | 2020-02-25 | 2025-08-11 |
| Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery Metformin Hydrochloride - Hyperglycemia, Metformin | Phase 4 | Unknown | Kepler University Hospital | 400 | 2020-02-01 | 2020-02-26 |
| The Efficacy and Safety of Faster Insulin Aspart (Fiasp®) Compared to Conventional Insulin Aspart (NovoLog®) as Correction Bolus Faster Insulin Aspart (Fiasp®) - Type 1 Diabetes Mellitus | Phase 4 | Unknown | Mountain Diabetes and Endocrine Center | 45 | 2019-03-27 | 2020-11-24 |
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Glucose Intolerance (61) · Diabetes Mellitus, Type 2 (40) · Insulin Resistance (31) · Diabetes Mellitus (30) · Obesity (16) · Hypoglycemia (11) · Prediabetic State (11) · Hypertension (7) · Cardiovascular Diseases (5) · Diabetes Mellitus, Type 1 (5) · Metabolic Syndrome (5) · Critical Illness (4) · Myocardial Infarction (4) · Overweight (4)
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