73 completed, 9 terminated, 9 unknown, 2 recruiting. 38 Phase 4, 30 Phase 3, 9 Phase 1, 8 Not applicable, 6 Phase 2.
Follow Insulin, Isophane: new trials by email Literature Review of Insulin, Isophane trials Research Report on Insulin, Isophane
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes Insulin Isophane Human, NPH, Pre-emptive Algorithm, Triamcinolone Acetonide Knee Injection - Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus | Phase 1 / Phase 2 | Active not recruiting | Shifa International Hospital | 125 | 2026-08-10 | 2026-09-15 |
| RCT Glargine vs NPH for Treatment of DM in Pregnancy Insulin glargine, insulin NPH - Diabetes Mellitus in Pregnancy, Type 2 Diabetes Mellitus (T2DM) | Phase 3 | Recruiting | Loyola University | 160 | 2024-04-01 | 2024-10-01 |
| DETERMINE: Detemir vs NPH Insulin Detemir, Insulin NPH - Gestational Diabetes, Diabetes Mellitus, Type 2 | Phase 2 | Recruiting | University of California, Los Angeles | 336 | 2022-02-01 | 2023-09-26 |
| Insulin for Hyperglycemia in Stroke Trial Analog Insulin, Human insulin - Hyperglycemia, Stroke, Acute | Phase 4 | Completed | National Institute of Neurosciences and Hospital, Dhaka | 452 | 2021-04-05 | 2021-12-06 |
| Dapagliflozin Effect in Cognitive Impairment in Stroke Trial Dapagliflozin 10mg Tab, Statins (Cardiovascular Agents), Platelet Antiaggregant - Stroke, Ischemic, Mild Cognitive Impairment | Phase 2 / Phase 3 | Unknown | Jaime Daniel Mondragon | 270 | 2020-08-01 | 2022-10-04 |
| Intermediate and Long Acting Insulin Young Children Type 1 Diabetes. Degludec, Glargine, NPH insulin - Type 1 Diabetes Mellitus With Hypoglycemia, type1diabetes | Phase 4 | Unknown | Ain Shams University | 60 | 2019-02-21 | 2021-02-16 |
| Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy Neutral Protamine Hagedorn (NPH), Detemir insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 108 | 2018-09-04 | 2021-09-16 |
| Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia NPH Insulin, glargine, Insulin Aspart - Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes | Phase 4 | Terminated | Northwestern University | 3 | 2018-03-27 | 2020-09-11 |
| Toujeo Versus NPH Self-titration Study Insulin Glargine 300 UNT/ML, Neutral protamine hagedorn insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Elaine Chow | 50 | 2018-01-01 | 2021-08-03 |
| Insulin Schemes for Type 2 Diabetes Control NPH insulin, Glargine and Lispro insulin - Type 2 Diabetes Mellitus | Phase 4 | Completed | Universidad de Guanajuato | 75 | 2017-11-02 | 2021-12-06 |
| A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus Insulin glulisine (U300), Insulin glulisine, Insulin aspart - Type1 Diabetes Mellitus | Phase 1 | Completed | Sanofi | 44 | 2017-02-17 | 2022-04-25 |
| A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulin in Patients Already Using Basal Insulin insulin glargine (U300), insulin glargine (U100), NPH insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 609 | 2015-12-21 | 2022-04-25 |
| A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulins in Insulin Naïve Patients Initiating Insulin insulin glargine (U300), insulin glargine (U100), NPH insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 705 | 2015-11-05 | 2022-04-25 |
| Insulin in Treatment of Diabetes Mellitus With Pregnancy Basal insulin analogue, rapid acting insulin, Neutral Protamine Hagedorn - Diabetes | Not applicable | Completed | Assiut University | 110 | 2015-01-01 | 2021-01-27 |
| A Trial Investigating the Efficacy and Safety of Insulin Detemir Versus Insulin NPH in Combination With Metformin and Diet/Exercise in Children and Adolescents With Type 2 Diabetes Insufficiently Controlled on Metformin With or Without Other Oral Antidiabetic Drug(s) With or Without Basal Insulin Insulin detemir, Insulin NPH, Diet/exercise - Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Terminated | Novo Nordisk A/S | 42 | 2014-06-11 | 2018-09-10 |
| Glucose Control for Glucocorticoid Induced Hyperglycemia During Chemotherapy Sliding scale insulin, Intermediate acting insulin, Dietary advice - Hyperglycemia Steroid-induced | Phase 4 | Completed | Slotervaart Hospital | 26 | 2014-05-01 | 2016-01-07 |
| A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007). Ertugliflozin 5 mg, Ertugliflozin 15 mg, Placebo to Ertugliflozin - Type 2 Diabetes Mellitus | Phase 3 | Completed | Merck Sharp & Dohme LLC | 621 | 2013-12-13 | 2018-09-10 |
| Glargine Versus NPH in Patients With Chronic Kidney Disease Glargine insulin, NPH insulin - Type 2 Diabetes Mellitus, Chronic Kidney Disease | Phase 4 | Completed | University of Sao Paulo General Hospital | 34 | 2013-12-01 | 2017-12-20 |
| Comparison of Insulin Therapy in Treating Post-Transplant Diabetes Insulin, Isophane, insulin glargine - Diabetes Mellitus | Phase 4 | Terminated | Inova Health Care Services | 2 | 2013-11-27 | 2022-07-26 |
| Comparison Study of Insulin Glargine and NPH Insulin Switching to NPH insulin, Continuation of insulin glargine - Diabetes | Phase 4 | Withdrawn | Providence Health & Services | 2013-04-01 | 2020-03-10 |
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Diabetes Mellitus (55) · Diabetes Mellitus, Type 2 (51) · Diabetes Mellitus, Type 1 (29) · Insulin Resistance (9) · Hyperglycemia (5) · Diabetes, Gestational (4) · Hypoglycemia (3) · Cognitive Dysfunction (1) · Dementia, Vascular (1) · Hypertension (1) · Ischemic Stroke (1) · Metabolic Syndrome (1) · Osteoarthritis, Knee (1) · Renal Insufficiency, Chronic (1) · Stroke (1)
Novo Nordisk A/S (46) · Sanofi (8) · Eli Lilly and Company (2) · Taipei Veterans General Hospital, Taiwan (2) · University of Sao Paulo General Hospital (2) · ikfe-CRO GmbH (2) · Ain Shams University (1) · Amsterdam UMC, location VUmc (1) · Assiut University (1) · Baylor College of Medicine (1) · Cook County Health (1) · Elaine Chow (1) · Emory University (1) · Hadassah Medical Organization (1) · HealthPartners Institute (1)
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Alireza Esteghamati, M.D. (1) · Ashley Hickman, MD (1) · Christina Han, MD (1) · David Baldwin, MD (1) · Elaine Chow (1) · Elizabeth Stephens, MD (1) · Evelyn Lacuesta, MD (1) · Glenn R Cunningham, MD (1)
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