14 terminated. 14 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Terminated 14 |
| Phase 2 | 5 | Terminated 5 |
Follow Heart Valve Diseases: new trials by email Literature Review of Heart Valve Diseases trials Research Report on Heart Valve Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy Mavacamten, Placebo - Cardiomyopathy, Hypertrophic | Phase 3 | Terminated | Bristol-Myers Squibb | 580 | 2022-12-14 | 2026-09-18 |
| PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban Apixaban 5 MG, Apixaban 2.5 MG, Warfarin - Aortic Valve Disease, Aortic Valve Stenosis | Phase 3 | Terminated | Artivion Inc. | 863 | 2020-05-01 | 2024-03-20 |
| RIvoraxaban in Mitral Stenosis Rivaroxaban, Warfarin - Mitral Stenosis, Rheumatic Heart Disease | Phase 3 | Terminated | Rajaie Cardiovascular Medical and Research Center | 40 | 2019-05-22 | 2021-08-19 |
| Rivaroxaban vs Warfarin in Patients With Metallic Prosthesis Rivaroxaban 15 mg, Warfarin - Prostheses and Implants, Stroke | Phase 2 / Phase 3 | Terminated | Hospital Geral Roberto Santos | 50 | 2018-07-10 | 2020-05-15 |
| Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) Ticagrelor alone, Combination lysine acetylsalicylate - clopidogrel - Aortic Valve Stenosis | Phase 3 | Terminated | University Hospital, Bordeaux | 50 | 2016-05-09 | 2026-06-22 |
| Mobilization of Endothelial Progenitor Cells and Aspirin Aspirin - Hypertrophic Obstructive Cardiomyopathy | Phase 3 | Terminated | Ottawa Heart Institute Research Corporation | 6 | 2016-05-01 | 2023-01-17 |
| Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy Eleclazine, Placebo - Hypertrophic Cardiomyopathy | Phase 2 / Phase 3 | Terminated | Gilead Sciences | 172 | 2015-02-05 | 2018-09-24 |
| Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL) Edwards Sapien XT Valve - Severe Tricuspid Regurgitation | Phase 2 / Phase 3 | Terminated | Charite University, Berlin, Germany | 28 | 2015-01-01 | 2018-09-18 |
| Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study) Atenolol, Telmisartan - Cardiac Disease | Phase 3 | Terminated | Hamilton Health Sciences Corporation | 85 | 2011-06-01 | 2019-09-18 |
| Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT) - Mitral Valve Insufficiency, Heart Failure | Phase 3 | Terminated | Duke University | 2 | 2008-03-01 | 2018-04-04 |
| Radiation Following Percutaneous Balloon Aortic Valvuloplasty to Prevent Restenosis External beam radiation therapy, Sham Control - Aortic Valve Stenosis | Phase 2 / Phase 3 | Terminated | Minneapolis Heart Institute Foundation | 21 | 2007-09-01 | 2019-10-01 |
| Adjuvant Radiation in Aortic Valvuloplasty - ARAVA Balloon Aortic Valvuloplasty, External Beam Radiation - Aortic Valve Stenosis | Phase 3 | Terminated | Medstar Health Research Institute | 60 | 2005-11-01 | 2010-05-31 |
| MPAACS: Magnesium for the Prevention of Atrial Arrhythmias After Cardiac Surgery intravenous magnesium - Coronary Artery Disease, Valvular Heart Disease | Phase 3 | Terminated | University of British Columbia | 927 | 2004-07-01 | 2010-11-04 |
| Conventional Versus Mini-Sternotomy for Aortic Valve Surgery surgery techniques (sternotomy for aortic valve replacement) - Heart Valve Diseases | Phase 2 / Phase 3 | Terminated | University Hospital, Bordeaux | 78 | 2002-01-01 | 2008-08-15 |
Aortic Valve Stenosis (4) · Cardiomyopathy, Hypertrophic (3) · Heart Failure (2) · Angina Pectoris (1) · Aortic Valve Disease (1) · Atrial Fibrillation (1) · Bicuspid Aortic Valve Disease (1) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Cardiomyopathy, Hypertrophic, Familial (1) · Coronary Artery Disease (1) · Dyspnea (1) · Heart Diseases (1) · Hemostatic Disorders (1)
Cardiovascular Diseases (14) · Heart Diseases (13) · Aortic Valve Disease (7) · Ventricular Outflow Obstruction (4) · Aortic Stenosis, Subvalvular (3) · Aortic Valve Stenosis (3) · Cardiomyopathies (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Vascular Diseases (3) · Genetic Diseases, Inborn (2) · Myocardial Ischemia (2) · Pathological Conditions, Signs and Symptoms (2) · Arrhythmias, Cardiac (1) · Arterial Occlusive Diseases (1)
Warfarin (3) · Rivaroxaban (2) · Aspirin (1) · Atenolol (1) · MYK-461 (1) · Sternotomy (1) · Telmisartan (1) · Ticagrelor (1) · acarboxyprothrombin (1) · apixaban (1) · eleclazine (1)
University Hospital, Bordeaux (2) · Artivion Inc. (1) · Bristol-Myers Squibb (1) · Charite University, Berlin, Germany (1) · Duke University (1) · Gilead Sciences (1) · Hamilton Health Sciences Corporation (1) · Hospital Geral Roberto Santos (1) · Medstar Health Research Institute (1) · Minneapolis Heart Institute Foundation (1) · Ottawa Heart Institute Research Corporation (1) · Rajaie Cardiovascular Medical and Research Center (1) · University of British Columbia (1)
Canada (5) · United States (5) · France (4) · Germany (3) · Australia (2) · Brazil (2) · Israel (2) · Italy (2) · Netherlands (2) · United Kingdom (2) · Austria (1) · Belgium (1) · China (1) · Czechia (1) · Denmark (1)
Andre Duraes, PhD (1) · Aun-Yeong Chong, MD, MRCP (1) · Eugene Braunwald, MD (1) · Gerard Janvier, Pr (1) · Hubert Wong, PhD (1) · Joachim Calderon, Dr (1) · John Alexander, MD (1) · Judith Therrien, MD (1) · Karin H Humphries, DSc (1) · Kerry L. Lee, PhD (1) · Lars Svensson, MD, PhD (1)
PMID 16539843, PMID 20659762, PMID 23713888, PMID 30293126, PMID 33150497, PMID 35306032, PMID 38320162, PMID 38625800, PMID 39026154, PMID 39909647, PMID 40425241, PMID 40864018, PMID 40888717
2015 (1), 2023 (1), U01HL084904 (1)