5 completed, 1 recruiting, 1 withdrawn. 7 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 5, Recruiting 1, Withdrawn 1 |
| Phase 1 | 1 | Withdrawn 1 |
Follow Heart Murmurs: new trials by email Literature Review of Heart Murmurs trials Research Report on Heart Murmurs
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension RTN-001, Matching placebo control - Uncontrolled Hypertension | Phase 2 | Recruiting | Retension Pharmaceuticals. Inc. | 280 | 2025-10-31 | 2026-11-04 |
| Interleukin-1 Blockade in HF With Preserved EF Anakinra, Placebo - Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Virginia Commonwealth University | 31 | 2014-09-01 | 2018-06-19 |
| Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure Placebo, rhNRG-1 Dose 1, rhNRG-1 Dose 2 - Chronic Heart Failure | Phase 2 | Completed | Zensun Sci. & Tech. Co., Ltd. | 67 | 2012-01-01 | 2025-02-10 |
| Safety of Phenylephrine Hydrochloride, Acetaminophen, Dimethindene Maleate Compared to Phenylephrine Hydrochloride Alone in Healthy Volunteers Phenylephrine HCL, Phenylephrine HCL/Acetaminophen/Dimethindene Maleate - Heart Rate, Blood Pressure | Phase 1 / Phase 2 | Withdrawn | Novartis | 2010-09-01 | 2016-03-03 | |
| Hyperuricemia on Hypertension and Metabolic Syndrome Allopurinol, placebo - Systolic and Diastolic Blood Pressure Levels, Uric Acid Levels | Phase 2 | Completed | Instituto Nacional de Cardiologia Ignacio Chavez | 40 | 2010-07-01 | 2014-07-24 |
| Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart Failure aliskiren, ramipril, Placebo to aliskiren - Heart Failure | Phase 2 | Completed | Novartis Pharmaceuticals | 123 | 2009-05-01 | 2012-07-26 |
| Evaluation of the Effects of Carperitide in Patients With Congestive Heart Failure Carperitide, Placebo - Heart Failure, Congestive, Heart Decompensation | Phase 2 | Completed | Daiichi Sankyo | 162 | 2004-01-01 | 2016-11-08 |
Systolic Murmurs (6) · Heart Failure (3) · Hypertension (2) · Arrhythmias, Cardiac (1) · Cardiomyopathies (1) · Heart Failure, Diastolic (1) · Hyperuricemia (1) · Inflammation (1) · Metabolic Syndrome (1) · Ventricular Dysfunction, Left (1)
Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Cardiovascular Diseases (6) · Heart Diseases (4) · Pathologic Processes (3) · Vascular Diseases (2) · Glucose Metabolism Disorders (1) · Hyperinsulinism (1) · Insulin Resistance (1) · Metabolic Diseases (1) · Nutritional and Metabolic Diseases (1) · Ventricular Dysfunction (1)
Allopurinol (1) · Dimethindene (1) · Interleukin 1 Receptor Antagonist Protein (1) · NPPA protein, human (1) · Oxymetazoline (1) · Ramipril (1) · aliskiren (1)
Daiichi Sankyo (1) · Instituto Nacional de Cardiologia Ignacio Chavez (1) · Novartis (1) · Novartis Pharmaceuticals (1) · Retension Pharmaceuticals. Inc. (1) · Virginia Commonwealth University (1) · Zensun Sci. & Tech. Co., Ltd. (1)
United States (4) · Brazil (1) · Canada (1) · Germany (1) · Mexico (1) · Poland (1) · Russia (1)
Antonio Abbate, MD, PhD (1) · Barry Greenberg, MD (1) · Benjamin Van Tassell, PharmD (1) · Biljana Pavlovic-Surjancev, MD, PhD (1) · Magdalena Madero, MD (1) · Uri Elkayam, MD (1)
PMID 21849262, PMID 28475816, PMID 30354558, PMID 33089502
R34HL118348 (1)