12 completed, 2 terminated, 1 not yet recruiting, 1 unknown. 16 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 12, Terminated 2, Not yet recruiting 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow Foot Deformities, Acquired: new trials by email Literature Review of Foot Deformities, Acquired trials Research Report on Foot Deformities, Acquired
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postsurgical Analgesia After Unilateral Bunionectomy AMT-143, Saline (NaCl 0,9 %) (placebo) - Bunionectomy, Bunion | Phase 2 | Not yet recruiting | AmacaThera Inc. | 60 | 2026-12-01 | 2026-10-22 |
| Post-Operative Pain and Opioid Reduction Trial After Bunionectomy Analgesic Non Narcotic - Hallux Valgus and Bunion | Phase 2 | Completed | Cali Pharmaceuticals LLC | 73 | 2022-06-14 | 2023-01-11 |
| Dose-Escalation Study of HTX-034 Following Bunionectomy HTX-034 low dose, HTX-034 high dose, Luer lock applicator - Bunions, Postoperative Pain | Phase 1 / Phase 2 | Completed | Heron Therapeutics | 78 | 2020-05-08 | 2026-06-09 |
| Dexmedetomidine Sedation in Orthopedic Surgery Dexmedetomidine, Midazolam, Remifentanil - Hallux Valgus and Bunion, Sedation | Phase 2 | Unknown | Asklepieion Voulas General Hospital | 60 | 2020-01-29 | 2020-01-30 |
| Effect of Topical CBD Cream for Degenerative Hallux Disorders magnesium-cannabidiolic acid cream, Placebo cream - Hallux Valgus, Hallux Rigidus | Phase 2 / Phase 3 | Terminated | Rush University Medical Center | 11 | 2019-10-20 | 2024-10-15 |
| The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population Chloroprocaine 1% Injectable Solution, Chloroprocaine 2% Injectable Solution - Hernia, Inguinal, Flat Foot | Phase 2 | Completed | Sintetica SA | 164 | 2019-02-14 | 2026-03-23 |
| Phase 2 Bunionectomy HTX-011 Administration Study HTX-011, Luer Lock applicator, Vial access device - Postoperative Pain | Phase 2 | Completed | Heron Therapeutics | 78 | 2018-10-24 | 2026-03-02 |
| Study of Wafermine™ for Post-bunionectomy or Abdominoplasty Pain Wafermine™ 50 mg, Wafermine™ 75 mg, Placebos - Acute Pain, Bunion | Phase 2 | Completed | iX Biopharma Ltd. | 125 | 2017-08-24 | 2018-07-23 |
| Liposome Bupivacaine for ANKLE Blocks Liposome bupivacaine - Hallux Valgus (Bunions) | Phase 2 | Completed | Catherine Vandepitte, M.D. | 40 | 2017-01-02 | 2020-09-11 |
| Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy HTX-011A, Saline Placebo, HTX-011B - Postoperative Pain, Bunions | Phase 2 | Completed | Heron Therapeutics | 430 | 2016-05-01 | 2026-02-23 |
| A Study Of The Effectiveness Of Wafermine Alone And In Combination With Opioids In Subjects Undergoing Bunionectomy Wafermine, Oxycodone, Placebo - Acute Pain | Phase 2 | Completed | iX Biopharma Ltd. | 72 | 2015-10-01 | 2016-02-23 |
| Placebo-Controlled Evaluation of N1539 Following Bunionectomy Surgery N1539, Intravenous Placebo - Pain, Post-operative | Phase 2 | Completed | Baudax Bio | 59 | 2015-08-01 | 2017-06-14 |
| Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Surgery Intranasal Dexmedetomidine, Intranasal Placebo - Pain, Post-operative | Phase 2 | Completed | Baudax Bio | 168 | 2014-10-01 | 2017-05-02 |
| Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Intranasal Dexmedetomidine, Intranasal Placebo - Pain, Post-operative | Phase 2 | Terminated | Baudax Bio | 95 | 2014-06-01 | 2015-12-10 |
| Intravenous Tapentadol in Post-Bunionectomy Pain Tapentadol, Matching Placebo - Bunion, Pain | Phase 2 | Completed | Grünenthal GmbH | 177 | 2011-09-01 | 2019-10-28 |
| A Safety Study of AQUAVAN® (Fospropofol Disodium) Injection for Sedation During Minor Surgical Procedures. AQUAVAN® (fospropofol disodium) Injection - Procedural Sedation | Phase 2 / Phase 3 | Completed | Eisai Inc. | 123 | 2006-05-01 | 2012-06-20 |
Bunion (14) · Pain, Postoperative (7) · Agnosia (5) · Hallux Valgus (4) · Pain (4) · Acute Pain (3) · Arteriovenous Fistula (1) · Dilatation, Pathologic (1) · Flatfoot (1) · Hallux Rigidus (1) · Hernia, Inguinal (1)
Foot Deformities (16) · Musculoskeletal Diseases (16) · Pathological Conditions, Signs and Symptoms (11) · Neurologic Manifestations (9) · Signs and Symptoms (9) · Pathologic Processes (7) · Postoperative Complications (7) · Nervous System Diseases (5) · Neurobehavioral Manifestations (5) · Pain (5) · Perceptual Disorders (5) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Pathological Conditions, Anatomical (2)
Bupivacaine (2) · Analgesics, Non-Narcotic (1) · Aprepitant (1) · Dexmedetomidine (1) · Injections (1) · Midazolam (1) · Oxycodone (1) · Remifentanil (1) · Sodium Chloride (1) · Tapentadol (1) · chloroprocaine (1) · fospropofol (1)
Baudax Bio (3) · Heron Therapeutics (3) · iX Biopharma Ltd. (2) · AmacaThera Inc. (1) · Asklepieion Voulas General Hospital (1) · Cali Pharmaceuticals LLC (1) · Catherine Vandepitte, M.D. (1) · Eisai Inc. (1) · Grünenthal GmbH (1) · Rush University Medical Center (1) · Sintetica SA (1)
United States (12) · Belgium (1) · Greece (1) · Italy (1) · Spain (1)
Neil Singla, MD (2) · Erol Onel (1) · James B Jones, MD, PharmD (1) · Simon Lee, MD (1) · Valeria Mosetti, MD (1)