14 completed, 5 terminated, 2 recruiting, 2 unknown. 7 Phase 2, 6 Phase 3, 5 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Terminated 4, Completed 2, Recruiting 1 |
| Phase 3 | 6 | Completed 3, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Not applicable | 5 | Completed 3, Terminated 1, Unknown 1 |
Follow Epilepsy, Absence: new trials by email Literature Review of Epilepsy, Absence trials Research Report on Epilepsy, Absence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Evaluating NPT 2042 Versus Placebo in Subjects Aged 16-75 Years With Genetic Generalized Epilepsy (GGE) and Absence Seizures NPT 2042, Placebo - Epilepsy, Generalized, Epilepsy, Absence | Phase 2 | Completed | NeuroPro Therapeutics, Inc. | 14 | 2025-03-11 | 2026-09-28 |
| BMB-101 in Absence Epilepsy and DEE BMB-101 - Absence Epilepsy, Jeavons Syndrome | Phase 2 | Recruiting | Bright Minds Biosciences Pty Ltd | 20 | 2024-12-05 | 2025-08-12 |
| A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy Brivaracetam Film-coated tablet, Brivaracetam oral solution - Childhood Absence Epilepsy, Juvenile Absence Epilepsy | Phase 3 | Active not recruiting | UCB Biopharma SRL | 70 | 2024-07-10 | 2026-08-27 |
| A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures BHV-7000, Placebo - Generalized Epilepsy | Phase 2 / Phase 3 | Terminated | Biohaven Therapeutics Ltd. | 27 | 2024-06-20 | 2026-03-24 |
| Assessing Comorbidities in Epilepsy Using Eye Movement Recordings Childhood Absence Epilepsy, Absence Seizures | Completed | Eysz, Inc. | 60 | 2024-04-15 | 2025-10-15 | |
| Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings Eysz Hyperventilation Recorder - Absence Epilepsy, Childhood, Absence Seizures | Completed | Eysz, Inc. | 65 | 2023-12-01 | 2025-10-15 | |
| A Study to Test the Long-term Safety, Tolerability and Efficacy of Brivaracetam in Study Participants 2 to 26 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy Brivaracetam Film-coated tablet, Brivaracetam oral solution - Childhood Absence Epilepsy, Juvenile Absence Epilepsy | Phase 3 | Completed | UCB Biopharma SRL | 84 | 2022-03-30 | 2025-10-22 |
| Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy Epilepsy, Absence | Completed | University Hospital Schleswig-Holstein | 49 | 2021-10-01 | 2025-07-08 | |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy Brivaracetam, Placebo - Childhood Absence Epilepsy, Juvenile Absence Epilepsy | Phase 3 | Completed | UCB Biopharma SRL | 153 | 2021-07-29 | 2026-08-04 |
| Ketogenic Diet for New-Onset Absence Epilepsy Modified Atkins Diet, Absence epilepsy medications - Absence Epilepsy, Ketogenic Dieting | Phase 3 | Recruiting | Johns Hopkins University | 40 | 2020-08-10 | 2026-05-07 |
| Detecting Absence Seizures Using Eye Tracking Eye movement analysis - Epilepsy, Generalized, Absence Epilepsy | Completed | Rachel Kuperman | 150 | 2020-07-15 | 2022-07-05 | |
| ECV - Epihunter Clinical Validation Epihunter - Absence Seizures, Absence Epilepsy | Not applicable | Completed | Epihunter NV | 102 | 2020-05-01 | 2022-04-04 |
| Flunarizine for Treatment Resistant Absence Epilepsy Flunarizine Hydrochloride - Childhood Absence Epilepsy, Juvenile Absence Epilepsy | Phase 2 | Terminated | University of British Columbia | 9 | 2019-09-20 | 2023-12-01 |
| Mutual Interactions Between Absence Epilepsy Seizures and the Integration of Sensory Stimuli Timed repetitive sensory stimulation - Childhood or Juvenile Absence Epilepsy | Not applicable | Terminated | Fondation Ophtalmologique Adolphe de Rothschild | 1 | 2018-06-07 | 2022-09-21 |
| Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures Cannabidiol Oral Solution - Childhood Absence Epilepsy | Phase 2 | Terminated | Radius Pharmaceuticals, Inc. | 11 | 2018-02-20 | 2023-06-18 |
| Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures Cannabidiol Oral Solution - Childhood Absence Epilepsy | Phase 2 | Terminated | Radius Pharmaceuticals, Inc. | 20 | 2017-12-29 | 2023-07-21 |
| Longitudinal Early Epilepsy Study MRI, 24h-EEG + video, Neuropsychological tests - Absence Epilepsy, Epilepsy, Absence | Unknown | Maastricht University Medical Center | 60 | 2016-09-01 | 2018-11-19 | |
| Does Body Positioning Affect the Yield of Hyperventilation in Routine Pediatric Electroencephalography - EEG Studies? hyperventilation while sitting up during routine EEG - Epilepsy, Absence | Not applicable | Unknown | Meir Medical Center | 50 | 2016-06-01 | 2016-05-10 |
| Transcutaneous Non-invasive Stimulation of the Vagus Nerve for the Treatment of Difficult-to-treat Epilepsy T-VNS® Stimulator cM02 (Transcutaneous Stimulation of the Vagus Nerve) - Epilepsy | Not applicable | Completed | cerbomed GmbH | 7 | 2009-08-01 | 2011-03-08 |
| A Pilot Study of Efficacy and Tolerability of Levetiracetam Monotherapy in Subjects With Childhood Absence Epilepsy Levetiracetam - Epilepsy, Childhood Absence Epilepsy | Not applicable | Completed | The Cleveland Clinic | 20 | 2006-12-01 | 2011-07-28 |
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Seizures (11) · Epilepsy (10) · Epilepsy, Generalized (3) · Myoclonic Epilepsy, Juvenile (2) · Drug Resistant Epilepsy (1) · Epilepsies, Myoclonic (1) · Epilepsy, Idiopathic Generalized (1) · Epilepsy, Tonic-Clonic (1) · Hyperventilation (1) · Lennox Gastaut Syndrome (1)
Brain Diseases (24) · Central Nervous System Diseases (24) · Epileptic Syndromes (24) · Nervous System Diseases (24) · Epilepsy, Generalized (21) · Epilepsy (14) · Neurologic Manifestations (11) · Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (11) · Epilepsies, Myoclonic (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Genetic Diseases, Inborn (1) · Respiration Disorders (1) · Respiratory Tract Diseases (1) · Signs and Symptoms, Respiratory (1)
brivaracetam (3) · Cannabidiol (2) · Ethosuximide (2) · Lamotrigine (2) · Valproic Acid (2) · Eye-Tracking Technology (1) · Flunarizine (1) · Levetiracetam (1) · Neuropsychological Tests (1) · Topiramate (1) · Videotape Recording (1)
UCB Biopharma SRL (3) · Eysz, Inc. (2) · Radius Pharmaceuticals, Inc. (2) · Biohaven Therapeutics Ltd. (1) · Bright Minds Biosciences Pty Ltd (1) · Children's Hospital Medical Center, Cincinnati (1) · Epihunter NV (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Icahn School of Medicine at Mount Sinai (1) · Johns Hopkins University (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Maastricht University Medical Center (1) · Meir Medical Center (1) · NeuroPro Therapeutics, Inc. (1) · Rachel Kuperman (1)
United States (16) · Georgia (4) · Italy (4) · Germany (3) · Romania (3) · Slovakia (3) · Australia (2) · Belgium (2) · France (2) · Netherlands (2) · Spain (2) · Ukraine (2) · Austria (1) · Canada (1) · Croatia (1)
Ahmed Elkashef, MD (2) · Avital Cnaan, PhD (1) · Deepak K Lachhwani, MD (1) · Dirk Loeckx, PhD (1) · Eric H Kossoff, MD (1) · Hal Blumenfeld, MD, PhD (1) · Helmut Laufs, PD Dr. med. (1) · Inken Toedt, Dr. phil. Dipl.-Psych. (1) · Jennifer Guo, MS (1) · Johan SH Vles, MD, PHD (1) · Martina Durner, M.D. (1) · Michiro Negishi, PhD (1) · Peter Adamson, MD (1)
PMID 20200383, PMID 28916534, PMID 35844134
2023 (3), R01NS037466 (1), R43NS129363 (1), U01NS045803 (1)