End Stage Renal Disease: Clinical Trials

396 completed, 91 unknown, 45 terminated, 31 recruiting. 259 Not applicable, 107 Phase 2, 59 Phase 4, 56 Phase 3, 47 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	259	Completed 161, Unknown 41, Terminated 19, Recruiting 16, Active not recruiting 9, Withdrawn 7, Not yet recruiting 3, Enrolling by invitation 2, Suspended 1
Phase 2	107	Completed 71, Terminated 14, Unknown 14, Recruiting 3, Withdrawn 3, Not yet recruiting 2
Phase 4	59	Completed 35, Unknown 9, Withdrawn 6, Active not recruiting 4, Terminated 4, Suspended 1
Phase 3	56	Completed 39, Unknown 9, Recruiting 3, Terminated 2, Withdrawn 2, Active not recruiting 1
Phase 1	47	Completed 35, Terminated 5, Not yet recruiting 2, Recruiting 2, Unknown 2, Withdrawn 1
Early Phase 1	5	Completed 3, Withdrawn 2

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
BicMag Study - Improving Mineral Buffering Capacity in Dialysis Patients D-Standard, D-Bic, D-Mag - End Stage Renal Disease	Not applicable	Not yet recruiting	Elisabethinen Hospital	91	2026-10-01	2026-06-23
A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide Ribupatide - End Stage Renal Disease, Renal Impairment	Phase 1	Recruiting	Kailera	32	2026-09-08	2026-10-01
Study of ChoironeX GalKO Porcine Thymokidney Xenotransplantation in End-Stage Renal Disease ChoironeX GalKO Porcine Thymokidney - End Stage Renal Disease	Phase 1	Not yet recruiting	Xeno Holdings (US), LLC dba ChoironeX	4	2026-09-01	2026-09-02
Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3 EPPComm Provider Training - Kidney Disease, Chronic, End Stage Renal Disease	Not applicable	Not yet recruiting	Temple University	70	2026-09-01	2026-06-12
Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis Bupropion Hydrochloride 150 MG - End Stage Renal Disease, Fatigue	Phase 1 / Phase 2	Not yet recruiting	The University of Texas Health Science Center at San Antonio	16	2026-08-24	2026-08-11
Pumpkin Seed Oil as a Nutraceutical for Hemodialysis Patients Pumpkin Seed Oil 1000 mg, Standard hemodialysis care - End Stage Renal Disease, Chronic Kidney Disease Requiring Chronic Dialysis	Not applicable	Recruiting	Al-Mustansiriyah University	100	2026-07-20	2026-07-17
The Effect of Intradialytic Eye Exercise in Hemodialysis Patients Intradialytic Eye Exercise - End Stage Renal Disease, Hemodialysis Complication	Not applicable	Enrolling by invitation	Pardis Specialized Wellness Institute	30	2026-06-01	2026-09-01
Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation Pegcetacoplan, Placebo - Delayed Graft Function, End Stage Renal Disease	Phase 3	Withdrawn	Apellis Pharmaceuticals, Inc.		2026-05-18	2026-09-02
Impact on Quality of Life of Symptoms Routine E-monitoring Among Dialysis Patients. No systematic monitoring of symptoms, Systematic monitoring of symptoms - End Stage Renal Disease	Not applicable	Recruiting	Central Hospital, Nancy, France	2293	2026-02-06	2026-02-13
Light Therapy in End Stage Kidney Disease Bright light, Dim Light - End Stage Renal Disease	Not applicable	Completed	University of Pennsylvania	8	2026-02-01	2026-10-19
Solv Multi-Pass Hemodialysis System In-Center Clinical Study Solv Multi-Pass Hemodialysis System - End Stage Renal Disease	Not applicable	Terminated	Mozarc Medical US LLC	4	2026-01-13	2026-10-01
Comparison of Individualized Sodium Management Versus Standard Treatment in Hemodialysis Hemodialysis or Hemodiafiltration either with sodium zero-diffusive treatment or standard treatment without sodium-control - End Stage Renal Disease	Not applicable	Recruiting	Fresenius Medical Care Deutschland GmbH	130	2025-12-16	2025-12-22
Drug Interaction Potential of Pro-Inflammatory Conditions None (Observational) - Diabetes Mellitus, Type 2, End Stage Renal Disease		Recruiting	Indiana University	150	2025-11-01	2026-01-22
Premarket Clinical Safety Assessment of the ELISIO™-HX ELISIO™-HX Dialyzer - Renal Failure, Acute Renal Failure	Not applicable	Completed	Nipro Medical Corporation	22	2025-09-08	2026-09-03
PReSeRVE-HD: Observational Study of the Merit HeRO® Graft and Super HeRO® in Patients on Hemodialysis HeRO® Graft System or Super HeRO® System - End Stage Renal Disease, Hemodialysis Access Failure		Recruiting	Merit Medical Systems, Inc.	100	2025-07-28	2026-06-01
Blood Flow Conditions and Sounds in AVFs MRI acquisition, US examination - End Stage Renal Disease	Not applicable	Recruiting	Mario Negri Institute for Pharmacological Research	15	2025-03-01	2025-09-04
Ventilatory Functions and Physical Intolerance in ESRD Adolescents: Response to Program of Walking With Dogs incentive spirometer and walking with dog, training by incentive spirometer only - End Stage Renal Disease, Hemolysis	Not applicable	Recruiting	Cairo University	40	2025-02-05	2025-03-06
The Effect of Home Based Tele-Exercise on Peritoneal Dialysis Patients Home-based Tele Exercise - End Stage Renal Disease, Peritoneal Dialysis Complication	Not applicable	Completed	Pardis Specialized Wellness Institute	30	2025-01-29	2025-08-12
CAPABLE Transplant CAPABLE Transplant- Open Label Pilot, CAPABLE Transplant- Randomized Control Trial - Quality of Life, Depression	Not applicable	Recruiting	Johns Hopkins University	43	2025-01-25	2026-07-20
Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula VasQ, Arteriovenous fistula creation for dialysis vascular access - End Stage Renal Disease	Not applicable	Recruiting	Laminate Medical Technologies	300	2025-01-13	2026-10-27

Showing 20 of 615. Sign in to see all of them.

Narrower conditions

Kidney Failure, Chronic (615)  ·  Renal Insufficiency, Chronic (72)  ·  Renal Insufficiency (43)  ·  Kidney Diseases (30)  ·  Cardiovascular Diseases (17)  ·  Inflammation (17)  ·  Arteriovenous Fistula (16)  ·  Anemia (14)  ·  Hyperparathyroidism, Secondary (12)  ·  Diabetes Mellitus (11)  ·  Motor Activity (11)  ·  Hyperphosphatemia (10)  ·  Heart Failure (9)  ·  Depression (8)  ·  Thrombosis (8)

Broader conditions

Disease Attributes (615)  ·  Female Urogenital Diseases (615)  ·  Female Urogenital Diseases and Pregnancy Complications (615)  ·  Male Urogenital Diseases (615)  ·  Pathologic Processes (615)  ·  Pathological Conditions, Signs and Symptoms (615)  ·  Chronic Disease (614)  ·  Urologic Diseases (613)  ·  Urogenital Diseases (612)  ·  Kidney Diseases (585)  ·  Renal Insufficiency (572)  ·  Renal Insufficiency, Chronic (543)  ·  Nutritional and Metabolic Diseases (72)  ·  Cardiovascular Diseases (63)  ·  Metabolic Diseases (57)

Interventions

Cinacalcet (10)  ·  Exercise (10)  ·  Tacrolimus (9)  ·  Blood Specimen Collection (8)  ·  Renal Dialysis (8)  ·  spleen fibrinolytic proteinase (human) (8)  ·  ferric pyrophosphate (7)  ·  Dietary Supplements (6)  ·  ferric citrate (6)  ·  Heparin (5)  ·  Kidney Transplantation (5)  ·  Mycophenolic Acid (5)  ·  Calcitriol (4)  ·  Cholecalciferol (4)  ·  Cognitive Behavioral Therapy (4)

Sponsors

Vanderbilt University (13)  ·  Amgen (12)  ·  Vantive Health LLC (12)  ·  Rockwell Medical Technologies, Inc. (10)  ·  Fresenius Medical Care Deutschland GmbH (8)  ·  Massachusetts General Hospital (8)  ·  Pardis Specialized Wellness Institute (8)  ·  London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (7)  ·  Ain Shams University (6)  ·  Cardenal Herrera University (6)  ·  Johns Hopkins University (6)  ·  Satellite Healthcare (6)  ·  Columbia University (5)  ·  NYU Langone Health (5)  ·  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (5)

Countries

United States (267)  ·  Canada (38)  ·  United Kingdom (28)  ·  France (24)  ·  Germany (24)  ·  China (22)  ·  Italy (20)  ·  Belgium (14)  ·  South Korea (14)  ·  Spain (14)  ·  Iran (11)  ·  Israel (11)  ·  Egypt (10)  ·  Switzerland (10)  ·  Taiwan (10)

Top investigators

Alp Ikizler, MD (11)  ·  Mohammad Ali Tabibi, Dr (6)  ·  Adrian Ebner, MD (5)  ·  Adam Ogna, MD (3)  ·  Aditi Gupta, MD (3)  ·  Arduino Arduini, MD (3)  ·  Jonathan Himmelfarb, MD (3)  ·  Peter Kotanko, MD (3)  ·  Raymond D Pratt, MD FACP (3)  ·  Valentina Forni Ogna, MD (3)  ·  Alan S. Kliger, M.D. (2)  ·  Alistair J Ingram, MD (2)  ·  Amy D Waterman, PhD (2)  ·  Ashwini Sehgal, MD (2)

Results publications

PMID 32390133, PMID 33586138, PMID 35018639, PMID 36472884, PMID 37651553, PMID 38189593, PMID 38899545, PMID 40576086, PMID 19339093, PMID 21564530, PMID 22422538, PMID 23137211, PMID 23149295, PMID 23332990, PMID 23970131, PMID 24011252, PMID 25136843, PMID 25293374, PMID 26463883, PMID 27587605, PMID 28094031, PMID 28301073, PMID 28506446, PMID 28910799, PMID 29621747, PMID 31826326, PMID 33283264, PMID 36472416, PMID 37916745, PMID 11562419, PMID 11739090, PMID 12490682, PMID 14678952, PMID 15213282, PMID 15327420, PMID 15384829, PMID 15385656, PMID 15450042, PMID 15689407, PMID 15806502, PMID 15930998, PMID 16034410, PMID 16105056, PMID 16459764, PMID 16724235, PMID 16758521, PMID 16775236, PMID 17167117, PMID 17699221, PMID 17848650

NIH funding

2019 (3), R01DK045604 (3), R01NR017018 (2), R34HL140477 (2), U01DK066597 (2), 2004 (1), 2009 (1), 2014 (1), 2015 (1), 2017 (1), 2018 (1), 2023 (1), 5RC2DK122397 (1), I01CX002009 (1), I01HX002639 (1)