17 completed, 4 terminated, 2 unknown, 2 withdrawn. 16 Phase 1, 12 Phase 2, 4 Not applicable, 1 Phase 3, 1 Phase 4.
Follow ferric pyrophosphate: new trials by email Literature Review of ferric pyrophosphate trials Research Report on ferric pyrophosphate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration - Plasma Cell Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 74 | 2027-04-20 | 2026-10-26 |
| Hemoglobin Maintenance in Pediatric ESRD (End-stage Renal Disease) Patients by Ferric Pyrophosphate Citrate (FPC) Triferic - End Stage Renal Disease | Phase 3 | Unknown | Rockwell Medical Technologies, Inc. | 150 | 2020-09-01 | 2021-04-21 |
| Study to Investigate the Pharmacokinetic Comparability of Dosing Triferic AVNU IV by Continuous Infusion and IV Bolus. Triferic - End Stage Renal Disease | Phase 1 / Phase 2 | Completed | Rockwell Medical Technologies, Inc. | 23 | 2020-06-25 | 2021-07-13 |
| A Study to Investigate the Effect of Triferic Plus Heparin Infusion Compared to Heparin Alone on Coagulation Parameters in Hemodialysis Patients Triferic, Heparin - End Stage Renal Disease | Phase 1 / Phase 2 | Completed | Rockwell Medical Technologies, Inc. | 12 | 2019-09-30 | 2020-12-02 |
| Determination of a Dose-dependent Effect of GOS on Iron Absorption, and Addition of Vitamin C ferrous fumarate, ferrous sulphate, ferric pyrophosphate - Iron-deficiency | Not applicable | Completed | Isabelle Herter-Aeberli | 46 | 2019-04-01 | 2019-07-25 |
| Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma Plerixafor, Temozolomide, Whole-Brain Radiotherapy (WBRT) - Glioblastoma, Glioblastoma With Primitive Neuronal Component | Phase 2 | Completed | Lawrence D Recht | 21 | 2018-12-04 | 2025-11-14 |
| TCR Genetically Engineered PBMC and PBSC After Melphalan Conditioning Regimen in Treating Participants With Relapsed and Refractory Multiple Myeloma 18F-FHBG, Aldesleukin, Cellular Therapy - HLA-A*0201 Positive Cells Present, NY-ESO-1 Positive Tumor Cells Present | Phase 1 | Withdrawn | Jonsson Comprehensive Cancer Center | 2018-07-10 | 2020-07-24 | |
| Equivalence of Triferic® (Ferric Pyrophosphate Citrate) Administered Via Hemodialysate and Intravenously to Adult CKD-5HD Patients Triferic - End Stage Renal Disease | Phase 1 / Phase 2 | Completed | Rockwell Medical Technologies, Inc. | 27 | 2017-10-01 | 2020-11-16 |
| Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer 18F-FHBG, Aldesleukin, Busulfan - HLA-A*0201 Positive Cells Present, Locally Advanced Malignant Neoplasm | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 5 | 2017-07-26 | 2023-11-01 |
| Triferic IRIDA (Iron-Refractory Iron-Deficiency Anemia) Protocol Fer-In-Sol, Shohl's solution, Triferic - Iron-Refractory Iron-Deficiency Anemia | Phase 2 | Terminated | Rockwell Medical Technologies, Inc. | 1 | 2017-01-17 | 2020-09-22 |
| Study of Intraperitoneal Triferic in Patients on Chronic Peritoneal Dialysis Triferic - Peritoneal Dialysis (PD), Anemia | Phase 1 | Completed | Rockwell Medical Technologies, Inc. | 30 | 2017-01-01 | 2019-08-08 |
| Iron Absorption From Iron Enriched Aspergillus Oryzae in Females Using Stable Isotope Methodology Ferric pyrophosphate, Aspiron, Ferrous sulfate - Iron Absorption | Not applicable | Completed | Iowa State University | 35 | 2016-10-28 | 2018-07-23 |
| HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs, Carmustine, Filgrastim - Human Immunodeficiency Virus 1 Positive, Stage I Adult Hodgkin Lymphoma | Phase 1 | Withdrawn | Fred Hutchinson Cancer Center | 2016-08-15 | 2018-11-20 | |
| Anemia in Inflammatory Bowel Disease oral liposomal iron - Anemia, Bowel Diseases, Inflammatory | Phase 4 | Unknown | Federal University of Juiz de Fora | 200 | 2016-08-01 | 2016-08-09 |
| Comparison of Iron Absorption From Extruded FePP-fortified Rice Containing Zinc, Citric Acid/Trisodium Citrate and EDTA Ferric Pyrophosphate and Zinc Oxide, Ferric Pyrophosphate and Zinc Sulphate, Ferric Pyrophosphate, ZnO, Citric Acid and Trisodium Citrate - Iron Deficiency and/or Anemia | Not applicable | Completed | Swiss Federal Institute of Technology | 30 | 2016-04-01 | 2016-12-07 |
| Pharmacokinetics and Absolute Bioavailability of Fer-In-Sol and Triferic Administered Orally With Shohl's Solution in Healthy Volunteers Triferic, Fer-In-Sol, Shohl's solution - Iron-refractory, Iron-deficiency Anemia (IRIDA) | Phase 1 | Completed | Rockwell Medical Technologies, Inc. | 14 | 2016-04-01 | 2019-02-01 |
| Pharmacokinetics and Preliminary Bioequivalence of Triferic (Ferric Pyrophosphate Citrate) Administered Via Hemodialysate and Intravenously to Adult CKD-5HD Patients Triferic - End Stage Renal Disease | Phase 1 | Completed | Rockwell Medical Technologies, Inc. | 13 | 2016-04-01 | 2019-02-01 |
| Lentiviral-mediated Gene Therapy of Fanconi Anemia Patients Subtype A IV administration of Genetically Engineered Hematopoietic Stem/Progenitors Cells (HSPCs), Genetically Engineered Hematopoietic Stem/Progenitor Cells, Laboratory Biomarker Analysis - Fanconi Anemia | Phase 1 / Phase 2 | Completed | Hospital Infantil Universitario Niño Jesús, Madrid, Spain | 9 | 2016-01-07 | 2024-03-21 |
| Triferic Pediatric Pharmacokinetic Protocol Triferic - End Stage Renal Disease | Phase 1 / Phase 2 | Completed | Rockwell Medical Technologies, Inc. | 22 | 2015-11-01 | 2018-10-25 |
| Pharmacokinetics of Triferic (Ferric Pyrophosphate Citrate) Administered Intravenously to Healthy Adult Volunteers Triferic - End Stage Renal Disease | Phase 1 | Completed | Rockwell Medical Technologies, Inc. | 12 | 2015-10-01 | 2019-08-20 |
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Kidney Failure, Chronic (7) · Anemia (3) · Anemia, Iron-Deficiency (3) · Lymphoma, Non-Hodgkin (3) · Renal Insufficiency, Chronic (3) · Fanconi Anemia (2) · Glioblastoma (2) · Gliosarcoma (2) · Iron-Refractory Iron Deficiency Anemia (2) · Colitis, Ulcerative (1) · Crohn Disease (1) · Glioma (1) · Hodgkin Disease (1) · Inflammatory Bowel Diseases (1) · Iron Deficiencies (1)
Rockwell Medical Technologies, Inc. (10) · Fred Hutchinson Cancer Center (5) · Jonsson Comprehensive Cancer Center (2) · Swiss Federal Institute of Technology (2) · City of Hope Medical Center (1) · Federal University of Juiz de Fora (1) · Hospital Infantil Universitario Niño Jesús, Madrid, Spain (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Iowa State University (1) · Isabelle Herter-Aeberli (1) · Lawrence D Recht (1) · National Cancer Institute (NCI) (1)
United States (18) · Switzerland (3) · Ghana (1) · Puerto Rico (1) · Spain (1)
Raymond D Pratt, MD, FACP (4) · Raymond D Pratt, MD FACP (3) · Hans-Peter Kiem (2) · Leona Holmberg (2) · Carla VA Antunes, MSc. MD (1) · Douglas W Sborov (1) · Elizabeth L Budde, MD,PhD (1) · Isabelle Herter-Aeberli, Dr. (1) · Juan A Bueren (1) · Lawrence Recht (1) · Manju B Reddy, PhD (1) · Mazyar Shadman (1) · Michael B Zimmermann, Prof. Dr. (1) · Michael Zimmermann, Prof.Dr., MD (1) · Raymond Pratt, MD (1)
PMID 24572205, PMID 25105369, PMID 25705682, PMID 26765407, PMID 27118452, PMID 28148685, PMID 31501599, PMID 32073619, PMID 32692367, PMID 34515338, PMID 39348419, PMID 39624016, PMID 39642902, PMID 40593578
P30CA015704 (3), P30CA033572 (1), P50CA107399 (1), R01HL116217 (1), U10CA180821 (1)