20 completed, 3 not yet recruiting, 3 withdrawn, 2 recruiting. 32 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 32 | Completed 20, Not yet recruiting 3, Withdrawn 3, Recruiting 2, Terminated 2, Suspended 1, Unknown 1 |
| Phase 2 | 5 | Completed 4, Terminated 1 |
Follow Encephalitis: new trials by email Literature Review of Encephalitis trials Research Report on Encephalitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild | Phase 1 | Not yet recruiting | Stony Brook University | 18 | 2026-10-01 | 2026-10-02 |
| First-in-Human Study Testing a New Antibody Treatment for Tick-Borne Encephalitis in Healthy Volunteers. Human monoclonal antibody TBE025, intravenous infusion - The Tick-borne Encephalitis Virus (TBEV) | Phase 1 | Not yet recruiting | Giuseppe Pantaleo | 18 | 2026-01-01 | 2026-01-29 |
| A Phase 1 Study Evaluating the Safety, Tolerability, and Immunogenicity of V4020 Vaccine in Healthy Volunteers V4020 - Venezuelan Equine Encephalitis, Venezuelan Equine Encephalitis Virus Infection | Phase 1 | Not yet recruiting | Medigen, Inc. | 39 | 2025-08-15 | 2025-07-28 |
| Phase 1 Study of ART5803 Safety and PK After IVIG in Healthy Participants ART5803, Intravenous immunoglobulin (IVIG) - Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder) | Phase 1 | Completed | Arialys Therapeutics | 7 | 2025-02-25 | 2026-04-27 |
| A Study to Assess the Safety, Reactogenicity, and Immunogenicity of SK Japanese Encephalitis Messenger Ribonucleic Acid (mRNA) Vaccines (GBP560) in Healthy Adults GBP560-A, GBP560-B, IXIARO - Japanese Encephalitis Virus Disease | Phase 1 / Phase 2 | Completed | SK Bioscience Co., Ltd. | 161 | 2025-02-24 | 2026-09-11 |
| Phase 1 Study of ART5803 in Healthy Participants ART5803 - Autoimmune Encephalitis | Phase 1 | Completed | Arialys Therapeutics | 64 | 2024-09-19 | 2026-04-27 |
| Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy 89 Zr-Df-crefmirlimab - Progressive Multifocal Leukoencephalopathy, Multiple Sclerosis | Phase 1 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 15 | 2023-10-19 | 2026-06-05 |
| Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)? Long term (continuous) prophylactic antibiotics, 24 hours antibiotics - Subarachnoid Hemorrhage, Intracerebral Hemorrhage | Phase 1 | Recruiting | Montefiore Medical Center | 84 | 2021-06-14 | 2026-08-10 |
| Vaccination Trial of a Recombinant MVA-BN-WEV Vaccine in Healthy Adult Subjects MVA-BN-WEV Dose 1, MVA-BN-WEV Dose 2, MVA-BN-WEV Dose 3 - Equine Encephalitis | Phase 1 | Completed | Bavarian Nordic | 45 | 2019-10-07 | 2020-08-20 |
| VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults VRC-WEVVLP073-00-VP, VRC-GENMIX083-AL-VP - Venezuelan Equine Encephalitis, Western Equine Encephalitis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2019-04-02 | 2021-03-24 |
| Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine Vaccinations on Day 0, Day 28, and Day 140 - Encephalitis, Encephalitis, Viral | Phase 1 | Unknown | SRI International | 48 | 2018-07-17 | 2021-02-23 |
| Measuring Brain Inflammation in Autism Minocycline - Autism Spectrum Disorder | Phase 1 | Suspended | University of California, Los Angeles | 30 | 2017-04-11 | 2020-08-10 |
| IL-2 in Refractory Autoimmune Encephalitis Proleukin - Encephalitis | Phase 1 / Phase 2 | Completed | Seoul National University Hospital | 10 | 2016-03-01 | 2021-09-29 |
| Stem Cell Transplantation In-patient With Neurological Sequelae Due to Encephalitis or Meningitis Stem cell transplantation - Encephalitis, Meningitis | Phase 1 / Phase 2 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 22 | 2014-06-16 | 2024-06-06 |
| Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers Venezuelan Equine Encephalitis Virus DNA Vaccine Candidate, 0.9% saline placebo - Venezuelan Equine Encephalitis Virus Infection | Phase 1 | Completed | Ichor Medical Systems Incorporated | 42 | 2013-12-01 | 2015-08-26 |
| Immune Response in IXIARO Batch JEV09L37 Recipients Before and After Revaccination IXIARO - Japanese Encephalitis | Phase 1 | Withdrawn | Valneva Austria GmbH | 2012-06-01 | 2013-03-08 | |
| Safety and Immunogenicity Study of an Inactivated Vaccine Against Hand, Foot and Mouth Disease Caused by Enterovirus 71 INV21 Low Dose, INV21 High Dose, Placebo - Hand, Foot and Mouth Disease | Phase 1 | Completed | Inviragen Inc. | 36 | 2011-08-01 | 2015-05-06 |
| Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) mefloquine - Progressive Multifocal Leukoencephalopathy | Phase 1 / Phase 2 | Terminated | Biogen | 37 | 2009-01-01 | 2014-07-31 |
| Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults WN/DEN4delta30 vaccine, Placebo - West Nile Fever | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 26 | 2008-03-01 | 2013-01-03 |
| Phase Ib Study of SC Milatuzumab in SLE milatuzumab, Placebo - Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Discoid | Phase 1 | Completed | Gilead Sciences | 22 | 2007-01-01 | 2021-08-19 |
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Encephalomyelitis, Venezuelan Equine (5) · West Nile Fever (5) · HIV Infections (3) · Alphavirus Infections (2) · Autoimmune Diseases of the Nervous System (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Encephalitis, Japanese (2) · Encephalitis, Tick-Borne (2) · Encephalomyelitis, Equine (2) · Leukoencephalopathy, Progressive Multifocal (2) · Toxoplasmosis (2) · Toxoplasmosis, Cerebral (2) · Virus Diseases (2)
Nervous System Diseases (31) · Neuroinflammatory Diseases (31) · Brain Diseases (30) · Central Nervous System Diseases (30) · Infections (25) · Central Nervous System Infections (21) · Virus Diseases (20) · RNA Virus Infections (19) · Central Nervous System Viral Diseases (18) · Encephalitis, Viral (16) · Infectious Encephalitis (16) · Arbovirus Infections (15) · Encephalitis, Arbovirus (15) · Vector Borne Diseases (15)
Leucovorin (2) · Pyrimethamine (2) · 11C-PS13 (1) · Anti-Bacterial Agents (1) · Azithromycin (1) · Foscarnet (1) · Ganciclovir (1) · Immunoglobulins, Intravenous (1) · Infusions, Intravenous (1) · Mefloquine (1) · Minocycline (1) · Rituximab (1) · Saline Solution (1) · Stem Cell Transplantation (1) · Zidovudine (1)
National Institute of Allergy and Infectious Diseases (NIAID) (9) · Arialys Therapeutics (2) · Sarepta Therapeutics, Inc. (2) · Bavarian Nordic (1) · Biogen (1) · California Pacific Medical Center Research Institute (1) · DynPort Vaccine Company LLC, A GDIT Company (1) · Gilead Sciences (1) · Giuseppe Pantaleo (1) · Ichor Medical Systems Incorporated (1) · Inviragen Inc. (1) · Medigen, Inc. (1) · Montefiore Medical Center (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Pfizer (1)
United States (22) · Australia (3) · Brazil (1) · Canada (1) · Germany (1) · Italy (1) · New Zealand (1) · Singapore (1) · Spain (1) · Switzerland (1) · United Kingdom (1) · Vietnam (1)
Anna Durbin, MD (2) · Sankalp Gokhale, MD, MBA (2) · Anna Durbin, M.D. (1) · B Luft (1) · Carlos Fierro, MD (1) · Clifford D (1) · Daniel S Reich, M.D. (1) · David C Altschul, MD (1) · Grace Chen, MD (1) · Julie E Ledgerwood, DO (1) · Kenneth D Laxer, M.D. (1) · Liem T Nguyen (1) · Luft B (1) · Michael Gandal, MD PhD (1) · Paul A Tambyah, MBBS (1)
PMID 18190252, PMID 21398392, PMID 23733308, PMID 27206386, PMID 28296863, PMID 28403842, PMID 35568049, PMID 38494412
R21AG102953 (1)