13 completed, 8 recruiting, 3 unknown, 1 not yet recruiting. 19 Not applicable, 2 Early Phase 1, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 11, Recruiting 5, Not yet recruiting 1, Unknown 1, Withdrawn 1 |
| Early Phase 1 | 2 | Recruiting 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 4 | 1 | Unknown 1 |
Follow E-cigarette Use: new trials by email Literature Review of E-cigarette Use trials Research Report on E-cigarette Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sex Differences in E-Cigarette Perception Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml) - Nicotine Dependence, E-cigarette Use | Not applicable | Recruiting | Yale University | 60 | 2026-07-30 | 2026-09-02 |
| An Online Intervention to Reduce E-cigarette Use and Cigarette Smoking Risk in Adolescents Virtual Intervention for Behavioral Empowerment (VIBE) - E-cigarette Use, Cigarette Smoking Risk | Not applicable | Not yet recruiting | University of Southern California | 150 | 2026-07-01 | 2026-06-03 |
| Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing Nicotine Content, Illegal cigarette price, E-cigarette price - Cigarette Smoking, E-cigarette Use | Not applicable | Recruiting | Virginia Polytechnic Institute and State University | 70 | 2025-12-01 | 2026-01-16 |
| The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth ENDS Prevention Intervention (TBD) - E-cigarette Use, Substance Use | Not applicable | Recruiting | University of Hawaii | 500 | 2025-10-15 | 2026-06-05 |
| A Trial of Varenicline for E-cigarette Cessation Varenicline 1mg BID, Placebo - E-cigarette Use, Vaping | Phase 2 | Recruiting | Yale University | 326 | 2025-10-14 | 2025-12-17 |
| Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks - Alcohol Use, E-cigarette Use | Not applicable | Completed | Mark J Rzeszutek, PhD | 737 | 2025-08-18 | 2026-10-15 |
| An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults Live Free From E-cigarettes - E-cigarette Use | Not applicable | Completed | University of Southern California | 105 | 2025-07-01 | 2026-06-01 |
| Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers E-cigarettes, Oral nicotine pouches - E-cigarette Use, Cigarette Smoking | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 200 | 2024-10-02 | 2026-03-12 |
| Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use Varenicline, Counseling, Guided Self-Change Booklets - Cigarette Smoking, E-Cigarette Use | Phase 1 | Completed | Yale University | 19 | 2024-04-01 | 2026-06-08 |
| Sex Differences in the Vascular Effects of E-cigarette Use Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor), Chronic estrogen exposure - E-cigarette Use | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 80 | 2023-12-02 | 2025-12-15 |
| Evaluation of the Electronic Cigarette Withdrawal Syndrome Transdermal Nicotine Patch, Placebo Nicotine Patch - E-cigarette Use, Withdrawal | Early Phase 1 | Recruiting | Johns Hopkins University | 150 | 2023-11-28 | 2026-07-15 |
| Developing E-liquid Product Standards (Sweet Spot Study) Vaping study EC A, Vaping study EC B, Vaping study EC C - Nicotine, Nicotine Vaping | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 150 | 2023-05-30 | 2025-04-10 |
| Vape-Free Text-Messaging: Pilot Study E-cigarette cessation text-messaging intervention, Standard care control using standard national resources - E-cigarette Use | Not applicable | Recruiting | Jovan Gwon, PhD, RN, FIAAN | 50 | 2023-05-25 | 2025-08-07 |
| Vaper to Vaper: A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping Peer Messaging, Peer Coaching via Text, Gamification - E-cigarette Use, Vaping | Not applicable | Completed | University of Massachusetts, Worcester | 71 | 2022-12-19 | 2025-09-04 |
| Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit Stanford Vaping Prevention curriculum - E-cigarette Use | Not applicable | Completed | Stanford University | 2779 | 2022-10-19 | 2026-05-27 |
| Smoking Prevention Program in Poland educational intervention - Smoking, Smoking Behaviors | Unknown | Wroclaw Medical University | 180 | 2022-03-15 | 2022-08-09 | |
| Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth ECIG lab session 1, ECIG lab session 2, ECIG lab session 3 - E-cigarette Use | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 88 | 2021-12-02 | 2024-11-22 |
| Impact of New Product Standards for JUUL Among Dual JUUL/Combusted Cigarette Users 5% nicotine content JUUL pod, 3% nicotine content JUUL pod - Smoking, E-cigarette Use | Not applicable | Withdrawn | Duke University | 2021-10-01 | 2021-08-25 | |
| BIDI Stick ENDS Abuse Liability and Puffing Topography Assessment Tobacco products - E-cigarette Use, Cigarette Smoking | Not applicable | Completed | BIDI Vapor | 18 | 2021-07-07 | 2021-10-11 |
| Attentional Bias Modification Training for E-cigarette Users Computerized attentional bias modification training, Placebo attention control training - E-cigarette Use, Tobacco Use Cessation | Not applicable | Unknown | University of Wisconsin, Milwaukee | 50 | 2021-06-09 | 2022-11-04 |
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Vaping (26) · Cigarette Smoking (5) · Smoking (3) · Tobacco Use Disorder (3) · Tobacco Use (2) · Alcohol Drinking (1) · Behavior, Addictive (1) · Cardiovascular Diseases (1) · Harm Reduction (1) · Lung Diseases (1) · Smoking Cessation (1) · Substance-Related Disorders (1) · Thrombosis (1) · Tobacco Use Cessation (1)
Behavior (26) · Smoking (23) · Tobacco Smoking (5) · Chemically-Induced Disorders (4) · Mental Disorders (4) · Tobacco Use (4) · Substance-Related Disorders (3) · Health Behavior (2) · Cardiovascular Diseases (1) · Compulsive Behavior (1) · Drinking Behavior (1) · Embolism and Thrombosis (1) · Impulsive Behavior (1) · Respiratory Tract Diseases (1) · Vascular Diseases (1)
Electronic Nicotine Delivery Systems (3) · Tobacco Products (2) · Varenicline (2) · BID protein, human (1) · Counseling (1) · Early Intervention, Educational (1) · NG-Nitroarginine Methyl Ester (1) · Tea (1) · Tobacco Use Cessation Devices (1)
University of Southern California (3) · Yale University (3) · Ohio State University Comprehensive Cancer Center (2) · Abramson Cancer Center at Penn Medicine (1) · Anna Stanhewicz, PhD (1) · BIDI Vapor (1) · Duke University (1) · Johns Hopkins University (1) · Jovan Gwon, PhD, RN, FIAAN (1) · Karolinska Institutet (1) · Mark J Rzeszutek, PhD (1) · Stanford University (1) · The University of Texas Health Science Center, Houston (1) · University of Cincinnati (1) · University of Hawaii (1)
United States (21) · Poland (2) · Sweden (1)
Lisa Fucito, PhD (2) · Theodore L Wagener, PhD (2) · Adam Leventhal, Ph.D. (1) · Andrea C Villanti, PhD, MPH (1) · Anna O Popko, MD (1) · Benjamin Toll, PhD (1) · Bonnie Halpern-Felsher, Ph.D. (1) · Danielle R Davis, PhD (1) · Denise D Tran, PhD (1) · James H Stein, MD (1) · Justin Strickland, Ph.D. (1) · Konrad Reszka, MD (1) · Krzysztof Szewczyk, MD, PhD (1)
PMID 35655314, PMID 37044158, PMID 37548804, PMID 37699050, PMID 38562810, PMID 38886719, PMID 39120901, PMID 40239848, PMID 40259422
K01DA056494 (1), P01CA200512 (1), P50CA196530 (1), R01CA242171 (1), R01CA263121 (1), R01CA290541 (1), R01CA296186 (1), R01DA057925 (1), R01HL139331 (1), R34DA050992 (1), U54DA036114 (1), U54DA058256 (1)