1575 completed, 596 recruiting, 532 terminated, 436 unknown. 3715 Phase 1, 1435 Phase 2.
Follow Digestive System Neoplasms: new trials by email Literature Review of Digestive System Neoplasms trials Research Report on Digestive System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Certepetide Phase 1b/2a Continuous Infusion Trial in mPDAC certepetide, nab-paclitaxel, gemcitabine - Pancreas Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Withdrawn | Lisata Therapeutics, Inc. | 2030-01-01 | 2025-06-06 | |
| Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma Biospecimen Collection, Diagnostic Imaging Testing, Echocardiography Test - Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 31 | 2027-06-01 | 2026-10-22 |
| Immunotherapy Treating GI Cancer engineered immune cells - Cancer | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2027-06-01 | 2026-11-02 |
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Daraxonrasib in Resectable PDAC Daraxonrasib, Surgical Resection, Adjuvant Chemotherapy - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer | Phase 1 | Not yet recruiting | Dana-Farber Cancer Institute | 30 | 2027-04-13 | 2026-10-27 |
| A Phase I/IIa Study of EF-009 in Patients With Pancreatic Cancer EF-009 - Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | Everfront Biotech Co., Ltd. | 30 | 2027-04-01 | 2026-09-11 |
| A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer Navlimetostat, mFOLFIRINOX Treatment Regimen - Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 / Phase 2 | Not yet recruiting | Daniel Nussbaum, M.D. | 18 | 2027-01-15 | 2026-11-02 |
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Outside the Cage (OTC) Robotic Esophagectomy OTC MIE Esophagectomy - Esophageal Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 31 | 2027-01-01 | 2026-03-18 |
| Study of ACC-1898 in Adult Participants With Advanced Solid Tumors ACC-1898 - Hepatocellular Carcinoma, Renal Cell Carcinoma | Phase 1 | Not yet recruiting | AccSalus Biosciences, Inc. | 40 | 2027-01-01 | 2026-10-28 |
| 64Cu-DOTA A2 scFv-Fc2 DM With Positron Emission Tomography for the Imaging of Patients With Locally Advanced or Metastatic PSCA-Expressing Pancreatic Cancer Biospecimen Collection, Copper Cu 64-DOTA-A2DM, Positron Emission Tomography - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 15 | 2026-12-16 | 2026-05-27 |
| A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC) DES-1357 - Metastatic Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Not yet recruiting | D. E. Shaw Research, LLC | 88 | 2026-12-03 | 2026-09-08 |
| ANO31905 in Combination With Chemotherapy for CLDN18.2-Positive Locally Advanced Unresectable or Metastatic Pancreatic Cancer ANO31905, AG [gemcitabine+nab-paclitaxel], mFOLFIRINOX [Oxaliplatin+irinotecan+leucovorin+fluorouracil] - Pancreatic Cancer | Phase 1 / Phase 2 | Recruiting | Anova Innovation Limited | 84 | 2026-12-01 | 2026-10-23 |
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Study of Tegavivint Plus Zanzalintinib in Patients With Advanced Hepatocellular Carcinoma Zanzalintinib, Tegavivint - Hepatocellular Carcinoma (HCC) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 36 | 2026-12-01 | 2026-10-16 |
| PDAC Regression and Intraoperative Surgical Margin With Neoadjuvant TAMP (PRISM-TAMP) Gemcitabine Delivered by Transarterial Microperfusion - Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Vermont | 10 | 2026-12-01 | 2026-03-17 |
| TCR1188-ABC Cells in KRAS-mutated Cancers TCR1188-ABC cells, Fludarabine + Cyclophosphamide combination, Tocilizumab - Cholangiocarcinoma, Colorectal Cancer | Phase 1 | Recruiting | University of Pennsylvania | 30 | 2026-12-01 | 2026-10-14 |
| Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients With Locally Advanced Pancreatic Adenocarcinoma (LAPC) PCX-12 - Pancreatic Adenocarcinoma | Phase 1 | Not yet recruiting | Haoming (Carl) Qiu | 24 | 2026-12-01 | 2026-02-05 |
Showing 20 of 3715. Sign in to see all of them.
Colorectal Neoplasms (1249) · Pancreatic Neoplasms (1055) · Stomach Neoplasms (655) · Carcinoma, Hepatocellular (609) · Carcinoma, Non-Small-Cell Lung (561) · Colonic Neoplasms (432) · Breast Neoplasms (424) · Ovarian Neoplasms (390) · Esophageal Neoplasms (381) · Neoplasms (371) · Neoplasm Metastasis (341) · Rectal Neoplasms (312) · Liver Neoplasms (282) · Melanoma (274) · Lung Neoplasms (273)
Digestive System Diseases (3700) · Neoplasms by Site (3660) · Neoplasms (3344) · Gastrointestinal Diseases (2338) · Gastrointestinal Neoplasms (2214) · Intestinal Diseases (1617) · Intestinal Neoplasms (1601) · Neoplasms by Histologic Type (1504) · Colonic Diseases (1480) · Rectal Diseases (1450) · Endocrine System Diseases (1350) · Endocrine Gland Neoplasms (1345) · Neoplasms, Glandular and Epithelial (1317) · Carcinoma (1162)
Gemcitabine (332) · Fluorouracil (235) · Oxaliplatin (234) · pembrolizumab (201) · Capecitabine (199) · Bevacizumab (172) · Irinotecan (168) · Leucovorin (168) · Nivolumab (138) · Cetuximab (136) · Cisplatin (134) · 130-nm albumin-bound paclitaxel (132) · Radiotherapy (110) · Paclitaxel (98) · Cyclophosphamide (95)
National Cancer Institute (NCI) (181) · M.D. Anderson Cancer Center (82) · Pfizer (48) · Novartis Pharmaceuticals (46) · Eli Lilly and Company (42) · Memorial Sloan Kettering Cancer Center (42) · AstraZeneca (36) · Washington University School of Medicine (35) · City of Hope Medical Center (33) · Roswell Park Cancer Institute (26) · West China Hospital (26) · Bristol-Myers Squibb (25) · Incyte Corporation (24) · Mayo Clinic (23) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (23)
United States (2119) · China (688) · Spain (300) · South Korea (286) · France (245) · United Kingdom (222) · Japan (220) · Australia (209) · Canada (205) · Germany (184) · Taiwan (161) · Italy (158) · Belgium (129) · Netherlands (128) · Singapore (78)
PMID 39863139, PMID 19192962, PMID 22473314, PMID 37598000, PMID 40056080, PMID 19949018, PMID 22002018, PMID 26808342, PMID 27816492, PMID 31401903, PMID 31527168, PMID 32939319, PMID 33001135, PMID 35046060, PMID 35219300, PMID 35362047, PMID 35537408, PMID 35771259, PMID 36897458, PMID 37082579, PMID 37496366, PMID 37590355, PMID 37788341, PMID 37934000, PMID 38885312, PMID 39462179, PMID 39920391, PMID 40443562, PMID 41044356, PMID 42201333, PMID 42580817, PMID 10235156, PMID 10496568, PMID 10628373, PMID 10811496, PMID 11573045, PMID 11705489, PMID 11743810, PMID 11870157, PMID 11919232, PMID 11919233, PMID 12049861, PMID 12196376, PMID 12393999, PMID 12454110, PMID 12528778, PMID 12576903, PMID 12607634, PMID 12663720, PMID 12680184
2023 (48), 2025 (33), 2016 (31), 2019 (27), 2017 (26), 2015 (23), 2018 (23), P30CA033572 (20), 2014 (14), P30CA016672 (14), UM1CA186689 (13), P30CA015083 (11), UM1CA186644 (10), UM1CA186690 (9), P30CA014089 (8)