2620 completed, 1392 unknown, 1052 recruiting, 762 terminated. 7041 Phase 2, 1435 Phase 1, 335 Phase 3.
Follow Digestive System Neoplasms: new trials by email Literature Review of Digestive System Neoplasms trials Research Report on Digestive System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Certepetide Phase 1b/2a Continuous Infusion Trial in mPDAC certepetide, nab-paclitaxel, gemcitabine - Pancreas Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Withdrawn | Lisata Therapeutics, Inc. | 2030-01-01 | 2025-06-06 | |
| The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp Shared Decision Making using a Patient Decision Aid. - Shared Decision Making, Colonic Polyp | Phase 2 | Not yet recruiting | Vejle Hospital | 110 | 2028-02-01 | 2026-04-30 |
| CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Metastatic Colorectal Cancer CA102N, TAS-102, Bevacizumab - Metastatic Colorectal Cancer | Phase 2 | Suspended | Holy Stone Healthcare Co., Ltd | 100 | 2027-12-01 | 2026-09-18 |
| Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome Shuganhuazhuo Formula, Targeted therapy, Immunotherapy - HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine | Phase 2 | Not yet recruiting | Xiang-Qian | 120 | 2027-09-01 | 2026-08-27 |
| Ampligen Combined With SOC Versus SOC Alone Following First-Line Therapy in Subjects With LAPC Rintatolimod - Pancreatic Cancer | Phase 2 | Suspended | AIM ImmunoTech Inc. | 90 | 2027-08-01 | 2026-08-19 |
| Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation DN022150+AG( Stage I ）, DN022150+AG（Stage II）, placebo+AG（Stage II） - Pancreatic Cancer, Pancreatic Carcinoma | Phase 2 / Phase 3 | Not yet recruiting | Jiangxi Kvvit Pharmaceutical Co., Ltd. | 465 | 2027-06-06 | 2026-06-18 |
| Multicenter Phase 2 Study of Envafolimab in Biliary Tract Cancers Envafolimab plus Gemcitabine&Cisplatin, Gemcitabine&Cisplatin - Biliary Tract Neoplasms | Phase 2 | Not yet recruiting | 3D Medicines (Sichuan) Co., Ltd. | 126 | 2027-06-01 | 2026-03-25 |
| Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma Biospecimen Collection, Diagnostic Imaging Testing, Echocardiography Test - Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 31 | 2027-06-01 | 2026-10-22 |
| Immunotherapy Treating GI Cancer engineered immune cells - Cancer | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2027-06-01 | 2026-11-02 |
| Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial Balstilimab, Biopsy Procedure, Biospecimen Collection - Colorectal Adenocarcinoma, Stage II Colorectal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 20 | 2027-05-25 | 2026-09-29 |
| PET/MRI in Rectal Cancer Total Neo-adjuvant Therapy, 18FDG-PET/MRI scan - Rectal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 40 | 2027-05-01 | 2026-10-28 |
| A Phase I/IIa Study of EF-009 in Patients With Pancreatic Cancer EF-009 - Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | Everfront Biotech Co., Ltd. | 30 | 2027-04-01 | 2026-09-11 |
| Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer Stereotactic body radiation treatment (SBRT) - Esophageal Cancer | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 22 | 2027-03-01 | 2026-10-28 |
| A Clinical Study Evaluating the Safety and Efficacy of Ivonescimab as Second-line Treatment in Patients With Advanced Hepatocellular Carcinoma Ivonescimab - Hepatocellular Carcinoma (HCC), HCC - Hepatocellular Carcinoma | Phase 2 | Not yet recruiting | MedSIR | 44 | 2027-03-01 | 2026-11-04 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer Navlimetostat, mFOLFIRINOX Treatment Regimen - Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 / Phase 2 | Not yet recruiting | Daniel Nussbaum, M.D. | 18 | 2027-01-15 | 2026-11-02 |
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab - Gastroesophageal Adenocarcinoma | Phase 2 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 184 | 2027-01-01 | 2026-07-10 |
| Vilastobart+Retifanlimab in BRCA or PALB2 Deficient PC vilastobart (XTX101), Retifanlimab - Pancreatic Cancer Metastatic | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2027-01-01 | 2026-08-14 |
| Alberta Cancer Exercise Dose in Colorectal Cancer Group Exercise Classes - Arm 1, Group Exercise Classes - Arm 2 - Cancer, Colorectal Cancer | Phase 2 | Not yet recruiting | University of Calgary | 90 | 2027-01-01 | 2026-11-03 |
| Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC) Cemiplimab - Colon and Rectal Cancer | Phase 2 | Recruiting | Columbia University | 20 | 2027-01-01 | 2026-11-04 |
Showing 20 of 7041. Sign in to see all of them.
Colorectal Neoplasms (1870) · Pancreatic Neoplasms (1253) · Carcinoma, Hepatocellular (1111) · Stomach Neoplasms (1083) · Rectal Neoplasms (714) · Esophageal Neoplasms (615) · Colonic Neoplasms (603) · Neoplasm Metastasis (403) · Esophageal Squamous Cell Carcinoma (353) · Neoplasms (348) · Liver Neoplasms (345) · Biliary Tract Neoplasms (272) · Carcinoma, Non-Small-Cell Lung (267) · Ovarian Neoplasms (207) · Breast Neoplasms (202)
Digestive System Diseases (7012) · Neoplasms by Site (6905) · Neoplasms (6693) · Gastrointestinal Diseases (4429) · Gastrointestinal Neoplasms (4288) · Intestinal Diseases (2621) · Intestinal Neoplasms (2599) · Rectal Diseases (2369) · Neoplasms by Histologic Type (2258) · Colonic Diseases (2181) · Neoplasms, Glandular and Epithelial (2061) · Carcinoma (1893) · Endocrine System Diseases (1484) · Endocrine Gland Neoplasms (1481)
Oxaliplatin (841) · Fluorouracil (729) · Capecitabine (630) · Gemcitabine (561) · Leucovorin (520) · Bevacizumab (511) · Irinotecan (482) · Cisplatin (397) · Radiotherapy (314) · Cetuximab (299) · pembrolizumab (252) · Paclitaxel (232) · Nivolumab (199) · Docetaxel (191) · S 1 (combination) (181)
National Cancer Institute (NCI) (260) · Fudan University (167) · Sun Yat-sen University (164) · M.D. Anderson Cancer Center (113) · Tianjin Medical University Cancer Institute and Hospital (86) · Memorial Sloan Kettering Cancer Center (85) · Shanghai Zhongshan Hospital (59) · Eli Lilly and Company (57) · Hoffmann-La Roche (55) · Alliance for Clinical Trials in Oncology (53) · Asan Medical Center (52) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (50) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (47) · The First Affiliated Hospital with Nanjing Medical University (47) · Samsung Medical Center (45)
United States (2553) · China (1977) · South Korea (533) · France (480) · Spain (403) · Germany (372) · Italy (339) · United Kingdom (320) · Canada (314) · Taiwan (280) · Japan (240) · Belgium (211) · Australia (188) · Netherlands (175) · Singapore (110)
Tim F Greten, M.D. (16) · Howard Safran, MD (12) · Salah-Eddin Al-Batran, Prof. Dr. (12) · Lin Shen, MD (10) · Steven R. Alberts, MD (10)
PMID 35623069, PMID 39863139, PMID 33538338, PMID 15496622, PMID 28712102, PMID 37934000, PMID 40340830, PMID 19192962, PMID 21561347, PMID 22646630, PMID 26808342, PMID 30642373, PMID 31401903, PMID 32251400, PMID 34143971, PMID 36852452, PMID 38592721, PMID 12049862, PMID 19097774, PMID 20375404, PMID 22473314, PMID 26187751, PMID 26313683, PMID 26884585, PMID 27602924, PMID 28223062, PMID 28434648, PMID 30207593, PMID 32716739, PMID 32816630, PMID 33198671, PMID 35660797, PMID 36529152, PMID 36657089, PMID 36990609, PMID 37598000, PMID 39437804, PMID 40341124, PMID 40341199, PMID 40812353, PMID 41044356, PMID 42836590, PMID 12540794, PMID 14616164, PMID 15273542, PMID 15927411, PMID 16099600, PMID 16908937, PMID 16971718, PMID 17042060
2023 (49), 2017 (42), 2025 (40), 2019 (34), 2009 (32), 2016 (30), 2015 (28), 2018 (28), P30CA015083 (25), 2014 (22), P30CA016672 (22), U10CA032102 (22), 2008 (21), P30CA033572 (16), P30CA060553 (15)