23 recruiting, 18 completed, 18 not yet recruiting, 8 active not recruiting. 48 Not applicable, 2 Phase 1, 2 Phase 2, 2 Phase 4, 1 Phase 3.
Follow Depression Disorders: new trials by email Literature Review of Depression Disorders trials Research Report on Depression Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pivotal U.S. Clinical Validation of AI-COA® for Depression and Anxiety Depression Disorders, Anxiety Disorders | Not yet recruiting | Deliberate Solutions Inc. | 650 | 2027-03-01 | 2025-12-12 | |
| Physical Activity for Depressive Symptoms in Adults With Obesity: A Randomized Controlled Feasibility Trial Supervised Physical Activity Program - Obesity & Overweight, Depression Disorders | Not applicable | Not yet recruiting | Universite du Quebec en Outaouais | 26 | 2027-01-01 | 2026-09-23 |
| Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems Brief video - Depression Disorders, ADHD | Not applicable | Not yet recruiting | New York State Psychiatric Institute | 1600 | 2026-10-01 | 2026-09-03 |
| Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients ZenctuaryVR+ Interactive Virtual Reality - Palliative Care, Refractory Pain | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-09-01 | 2026-04-22 |
| Couples' Affect in Relationships Study well-being app, List of well-being resources - Depression Disorders | Not applicable | Recruiting | University of Wisconsin, Madison | 2000 | 2026-08-04 | 2026-10-13 |
| Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation - Anxiety, PTSD | Not applicable | Active not recruiting | Tactical Mind Research Coalition, Inc. | 240 | 2026-08-01 | 2026-09-16 |
| Cost-effectiveness and Implementation of a Transdiagnostic Internet-based Intervention for Emotional Disorders in Community Care. Internet-based psychological intervention, Treatment as usual (TAU) - Emotional Disorders, Depression Anxiety Disorder | Not applicable | Not yet recruiting | Universitat Jaume I | 200 | 2026-04-01 | 2026-03-18 |
| Improving the Treatment of Depression Among Youth With HIV COMBEX, COMB - Depression Disorders, HIV (Human Immunodeficiency Virus) | Not applicable | Not yet recruiting | Rhode Island Hospital | 130 | 2026-04-01 | 2026-02-27 |
| BasketballRx: Game Changing Health BasketballRx - Pediatric Obesity, Pediatric Overweight | Not applicable | Completed | Milton S. Hershey Medical Center | 8 | 2026-03-03 | 2026-09-30 |
| Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study Participants are followed while using cannabis-based products (such as CBD or THC oils, extracts, or isolates) as prescribed by their own physicians for therapeutic purposes. - Chronic Pain, Depression Disorders | Enrolling by invitation | Santa Catarina Federal University | 384 | 2026-03-01 | 2026-03-30 | |
| Validate the Temporal Stability and Responsiveness of AI-COA® for Depression and Anxiety Depression Disorders, Anxiety Disorders | Not yet recruiting | Deliberate Solutions Inc. | 150 | 2026-03-01 | 2025-12-12 | |
| Enhanced Ward Rounds and Communication for Pre-procedural Anxiety in GI Endoscopy Patients Enhanced Ward-Round Frequency With Standardized Communication, Usual Care Ward Rounds (2/day) - Anxiety, Depression Disorders | Not applicable | Not yet recruiting | LanZhou University | 1000 | 2026-01-15 | 2025-12-16 |
| Personalized TACS to Reduce Rumination in Patients with Active Suicidal Ideation Sham alpha-tACS, alpha-tACS - Suicidal Ideation Active, Depression Disorders | Not applicable | Not yet recruiting | Sebastian Olbrich | 50 | 2026-01-01 | 2025-02-18 |
| AI Platform for Fatigue and Depression Detection AI-enabled Okaya platform - Depression Disorders, Fatigue Symptom | Not applicable | Completed | Brijesh Patel | 100 | 2025-12-22 | 2026-08-19 |
| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder CYB003, Psychological Support - Major Depressive Disorder (MDD), Depression in Adults | Phase 3 | Recruiting | Cybin IRL Limited | 330 | 2025-12-10 | 2026-10-27 |
| Teen Recovery Through Inspiration, Support, and Empowerment Peer Support Services Recovery - Suicidal Ideation, Suicide Attempt | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 40 | 2025-11-05 | 2026-01-30 |
| Unified Protocol in Penitentiary Facilities Unified Protocol - Depression Disorders, Anxiety | Not applicable | Not yet recruiting | Instituto de Investigación Sanitaria Aragón | 25 | 2025-11-01 | 2025-07-17 |
| Clinical Study of Compound Ciwujia Granules in the Treatment of Depression Compound Ciwujia Granules, placebo - Depression - Major Depressive Disorder, Depression Disorders | Phase 4 | Active not recruiting | Shanghai Mental Health Center | 60 | 2025-10-01 | 2026-04-23 |
| A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder AFA-281 - Alcohol Abuse, Alcohol Abuse/addiction | Phase 2 | Not yet recruiting | Afasci Inc | 36 | 2025-10-01 | 2024-11-29 |
| SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety Fluoxetine (drug), Placebo - Hepatobiliary Malignancy, Fluoxetine | Phase 2 | Recruiting | First Affiliated Hospital of Wenzhou Medical University | 240 | 2025-10-01 | 2026-03-24 |
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Anxiety Disorders (35) · Depression (27) · Psychological Well-Being (11) · Suicidal Ideation (5) · Bipolar Disorder (4) · Mood Disorders (4) · Motor Activity (4) · Stress Disorders, Post-Traumatic (4) · Attention Deficit Disorder with Hyperactivity (3) · Cognitive Dysfunction (3) · Depressive Disorder, Major (3) · Diabetes Mellitus (3) · Emotional Regulation (3) · Generalized Anxiety Disorder (3) · Respiration Disorders (3)
Mental Disorders (48) · Behavior (43) · Behavioral Symptoms (35) · Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (12) · Personal Satisfaction (11) · Nervous System Diseases (9) · Mood Disorders (7) · Neurologic Manifestations (7) · Respiratory Tract Diseases (7) · Chemically-Induced Disorders (6) · Nutritional and Metabolic Diseases (6) · Digestive System Diseases (5) · Lung Diseases (5) · Neurocognitive Disorders (5)
Therapeutics (3) · Exercise (2) · Acclimatization (1) · Antidepressive Agents (1) · Community Participation (1) · Control Groups (1) · Dashboard Systems (1) · Duloxetine Hydrochloride (1) · Eye Movement Desensitization Reprocessing (1) · Fluoxetine (1) · Medical Marijuana (1) · Pharmaceutical Preparations (1) · Steam Bath (1) · Surveys and Questionnaires (1) · Tobacco Use Cessation Devices (1)
Deliberate Solutions Inc. (3) · Instituto de Investigación Sanitaria Aragón (2) · Shanghai Mental Health Center (2) · University of Texas Southwestern Medical Center (2) · Afasci Inc (1) · Al-Nahrain University (1) · Anhui Medical University (1) · Ataturk University (1) · Aura (1) · Brijesh Patel (1) · Centre for Addiction and Mental Health (1) · Child Mind Institute (1) · Children's Hospital Medical Center, Cincinnati (1) · Chung Shan Medical University (1) · Comenius University (1)
United States (21) · China (7) · Spain (4) · Canada (3) · Germany (3) · Poland (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Greece (2) · Taiwan (2) · Australia (1) · Belgium (1) · Brazil (1) · Chile (1) · Czechia (1)
Marc Aafjes (3) · Joseph Guillory, M.D. (2) · Agnieszka Piekarska, MD PhD (1) · Alexandra Brazinova, prof. MD PhD (1) · Anna Tosteson, ScD (1) · Azucena Garcia-Palacios, Psychology (1) · Beatrice Macciotta Felices, Dr. (1) · Benoit H Mulsant, MD, MS (1) · Brian Pinkston, MD, MPH (1) · Cheryl Lowry, MD, MPH (1) · Doron Amsalem, MD (1) · Douglas Steele (1) · Erum Tanveer (1)
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