153 completed, 29 unknown, 19 not yet recruiting, 19 recruiting. 181 Not applicable, 11 Phase 2, 5 Phase 3, 5 Phase 4, 2 Phase 1.
Follow Dental Anxiety: new trials by email Literature Review of Dental Anxiety trials Research Report on Dental Anxiety
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment Intracanal Cryotherapy, Standard Room-Temperature Irrigation - Postoperative Pain After Endodontic Treatment, Dental Anxiety | Not applicable | Not yet recruiting | Alanya Alaaddin Keykubat University | 130 | 2026-11-01 | 2026-10-22 |
| Music Therapy to Improve Dental Procedure Tolerance and Reduce Distress in Adults With Intellectual and Developmental Differences Live Music Therapy, Recorded Music - Intellectual and Developmental Differences, Dental Anxiety | Not applicable | Not yet recruiting | University of Rochester | 50 | 2026-10-30 | 2026-09-25 |
| Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent. Dental Pain, Dental Anxiety | Recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-10-08 | 2026-10-13 | |
| Effect of Alpha-Band Binaural Beats on Stress and Recovery in Third Molar Surgery 10 Hz Alpha-Band Binaural Beats Track, Continuous Rain Sound (Placebo), Active Noise Cancellation (ANC) - Dental Anxiety, Postoperative Pain | Not applicable | Recruiting | Alperen Kalyoncu | 90 | 2026-09-28 | 2026-10-19 |
| Intranasal Dexmedetomidine for Severe Dental Anxiety: a Randomized Trial Dexmedetomidine - Dental Anxiety | Not applicable | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 30 | 2026-09-08 | 2026-09-30 |
| Virtual Reality During Periodontal Frenectomy Virtual Reality-Based Audiovisual Distraction, Standard Periodontal Frenectomy - Dental Anxiety, Frenectomy | Not applicable | Not yet recruiting | Muhammed Emin Kalender | 70 | 2026-09-01 | 2026-08-12 |
| Passiflora Incarnata for Dental Extraction Anxiety Passiflora incarnata extract, Placebo - Dental Anxiety, Preoperative Anxiety | Not applicable | Completed | Ömer faruk Kaygısız | 72 | 2026-08-25 | 2026-10-15 |
| Multisensory Approaches for Managing Pediatric Dental Anxiety Basic Behavior Guidance, Deep Pressure Stimulation, Virtual Reality Distraction - Pediatric Dental Anxiety, Dental Anxiety | Not applicable | Recruiting | Bezmialem Vakif University | 60 | 2026-08-19 | 2026-09-30 |
| Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy Computer-Controlled Local Anesthesia, Conventional Inferior Alveolar Nerve Block, Articaine hydrochloride with epinephrine 1:100,000 - Dental Anxiety, Pain | Not applicable | Not yet recruiting | Recep Tayyip Erdogan University Training and Research Hospital | 38 | 2026-08-12 | 2026-08-12 |
| Effects of Topical Anesthetics on Pain and Anxiety in Children Dental Anxiety, Children | Not yet recruiting | Recep Tayyip Erdogan University Training and Research Hospital | 160 | 2026-07-30 | 2026-07-29 | |
| Virtual Reality Storytelling Versus Storybook Reading for Dental Anxiety in Children Virtual Reality Storytelling, Traditional Storybook Reading - Dental Anxiety, Dental Anxiety in Children | Not applicable | Recruiting | King Abdulaziz University | 108 | 2026-07-21 | 2026-10-07 |
| Virtual Reality to Reduce Anxiety in Adults Having Lower Wisdom Tooth Surgery Immersive Virtual Reality (Meta Quest 3) - Dental Anxiety, Mandibular Third Molar | Not applicable | Recruiting | Hanoi Medical University | 120 | 2026-06-09 | 2026-10-01 |
| Digital Storytelling-Based Animation for Preoperative Anxiety in Children Digital Storytelling-Based Animation - Preoperative Anxiety, Dental Anxiety | Not applicable | Completed | Recep Tayyip Erdogan University | 70 | 2026-06-05 | 2026-09-17 |
| Comparasion of Dental Anxiety in First Time Complete Denture Patients conventional complete denture fabrication - Edentulous Mouth, Dental Anxiety | Not applicable | Not yet recruiting | Khyber College of dentistry | 70 | 2026-05-01 | 2026-05-19 |
| Comparison of Needle-Free Injection and Conventional Syringe for Tooth Extractions in Children Needle-Free Jet Injection System, Conventional Syringe Injection - Tooth Extraction, Dental Anxiety | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 60 | 2026-04-15 | 2026-04-29 |
| Clinical Study Evaluating the Effect of Virtual Reality on Reducing Patients' Anxiety During Wisdom Teeth Extraction Virtual reality HypnoVR® (VR headset + hypnotic software), Control Group (No VR) - Dental Anxiety, Third Molar Extraction | Not applicable | Recruiting | University Hospital, Strasbourg, France | 60 | 2026-04-10 | 2026-08-20 |
| Evaluation of Augmented Reality on Dental Pain and Anxiety During Primary Molars' Extraction Augmented reality glasses, VR glasses - Dental Anxiety | Not applicable | Not yet recruiting | Sara Hazem Mohamed Rabie | 30 | 2026-04-01 | 2026-03-12 |
| Effect of Nature Sounds During Dental Filling on Anxiety in Older Adults Nature Sounds, White Noise - Dental Anxiety | Not applicable | Not yet recruiting | EMRE ERKAL | 78 | 2026-03-15 | 2026-03-09 |
| The Effect of a Kaleidoscope and Cartoons for Dental Treatment in Children Kaleidoscope Distraction, Cartoon Distraction - Dental Anxiety, Dental Fear | Not applicable | Recruiting | Dicle University | 126 | 2026-03-10 | 2026-03-13 |
| Effect of Music on Dental Anxiety and Physiological Responses During Dental Drill and Suction Sounds Music intervention - Dental Anxiety, Music Intervention | Not applicable | Completed | Armed Forces Institute of Dentistry, Pakistan | 74 | 2026-03-03 | 2026-10-16 |
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Anxiety Disorders (17) · Pain (17) · Toothache (17) · Agnosia (11) · Child Behavior (9) · Behavior (8) · Dental Caries (5) · Pain, Postoperative (3) · Stomatognathic Diseases (3) · Tooth, Impacted (3) · COVID-19 (2) · Infant Behavior (2) · Patient Compliance (2) · Periodontitis (2) · Phobia, Specific (2)
Pathological Conditions, Signs and Symptoms (52) · Signs and Symptoms (49) · Neurologic Manifestations (48) · Stomatognathic Diseases (30) · Tooth Diseases (28) · Mental Disorders (21) · Pain (19) · Behavior (18) · Facial Pain (17) · Nervous System Diseases (17) · Neurobehavioral Manifestations (14) · Perceptual Disorders (11) · Mouth Diseases (5) · Pathologic Processes (5) · Tooth Demineralization (5)
Midazolam (7) · Epinephrine (5) · Music Therapy (5) · Aromatherapy (4) · Control Groups (4) · Dexmedetomidine (3) · Heart Rate (3) · Hypnosis (3) · Lidocaine (3) · lavender oil (3) · Acupressure (2) · Anesthesia, Local (2) · Carticaine (2) · Cognitive Behavioral Therapy (2) · Dental Atraumatic Restorative Treatment (2)
Mansoura University (5) · Recep Tayyip Erdogan University Training and Research Hospital (5) · Cairo University (4) · Damascus University (4) · Hams Hamed Abdelrahman (4) · Karadeniz Technical University (4) · Kutahya Health Sciences University (4) · University of Malaya (4) · Ain Shams University (3) · Altamash Institute of Dental Medicine (3) · Ankara University (3) · Ataturk University (3) · Erzincan University (3) · Karolinska Institutet (3) · Nourhan M.Aly (3)
Turkey (Türkiye) (76) · Egypt (26) · United States (18) · Brazil (8) · France (6) · Pakistan (6) · Saudi Arabia (6) · Syria (6) · China (5) · Malaysia (5) · Spain (4) · United Kingdom (4) · Canada (3) · Iraq (3) · Sweden (3)
Karin ML Dowidar, PhD (2) · Liane M Souza, PhD (2) · Nadia A Wahba, PhD (2) · Rizk A Elagamy, PhD (2) · Salwa M Awad, Prof (2) · Sylvie Le May, PhD (2) · Abdul Wahab Nourallah, Prof (1) · Adela Planerova (1) · Ahmad H Wahba, PhD (1) · Ahmet C Talmac (1) · Aisyah Ahmad Fisal, BDS, MSCD RCSEd, D.Ch.Dent SCD (1) · Akram Deghady, PhD (1) · Alaa M Albakr, Master (1)
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U54DE014254 (2), U01DE016750 (1), U01DE016752 (1), U01DE027328 (1), UM1TR005451 (1)