15 completed, 8 recruiting, 6 not yet recruiting, 5 unknown. 43 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 43 | Completed 15, Recruiting 8, Not yet recruiting 6, Unknown 5, Withdrawn 5, Suspended 2, Active not recruiting 1, Terminated 1 |
Follow Demyelinating Diseases: new trials by email Literature Review of Demyelinating Diseases trials Research Report on Demyelinating Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| A Clinical Study to Evaluate the Safety and Efficacy of GT802 Injection in the Treatment of Relapsing/Refractory Multiple Sclerosis GT802 Injection - Multiple Sclerosis (MS) | Early Phase 1 | Not yet recruiting | Daishi Tian | 12 | 2026-10-28 | 2026-09-14 |
| A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Autoimmune Diseases LVIVO-TaVec400 product - Relapsed/Refractory Systemic Lupus Erythematosus (r/r SLE), Relapsed/Refractory IgG4-Related Disease (r/r IgG4-RD) | Early Phase 1 | Withdrawn | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2026-09-23 | 2026-10-02 | |
| Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD Gentamicin, Lactobacillus Rhamnosus GG - Spinal Cord Injury, Neurogenic Bladder (NB) | Early Phase 1 | Not yet recruiting | Medstar Health Research Institute | 48 | 2026-08-01 | 2026-08-21 |
| The Safety and Efficacy of KSVCBD Injection in Neuromyelitis Optica Spectrum Disorder. KSVCBD injection - Neuromyelitis Optica Spectrum Disease (NMOSD) | Early Phase 1 | Not yet recruiting | Chinese PLA General Hospital | 18 | 2026-05-15 | 2026-05-18 |
| An Open-Label, Single-Arm Clinical Study to Evaluate the Safety and Preliminary Efficacy of CD20 Monoclonal Antibody Combined With NK042 Cell Injection in the Treatment of Multiple Sclerosis (MS). NK042, ofatumumab - Multiple Sclerosis | Early Phase 1 | Not yet recruiting | The Affiliated Hospital of Xuzhou Medical University | 20 | 2026-05-01 | 2026-04-22 |
| This is an Early Exploratory Study to Assess the Tolerability and Safety of GC012F in Patients With Multiple Sclerosis GC012F CAR-T Cell Injection - Multiple Sclerosis | Early Phase 1 | Recruiting | Daishi Tian | 9 | 2026-03-09 | 2026-05-22 |
| Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/ BCMA（QT-019C） in Patients With r/ r Neurological Autoimmune Diseases QT-019C - Neuromyelitis Optica Spectrum Disorders, Multiple Sclerosis | Early Phase 1 | Not yet recruiting | Tianjin Huanhu Hospital | 15 | 2026-03-01 | 2026-02-11 |
| This is an Open-Label Study to Assess the Safety and Efficacy of GC012F in Patients With Multiple Sclerosis GC012F CAR-T Cell Injection - Multiple Sclerosis | Early Phase 1 | Withdrawn | Huashan Hospital | 2026-01-26 | 2026-03-30 | |
| CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases CD19/BCMA-targeted CAR-T cells, Lymphodepleting Conditioning - Relapsing or Refractory Multiple Sclerosis (MS), Myasthenia Gravis (MG) | Early Phase 1 | Recruiting | Tongji Hospital | 36 | 2025-12-12 | 2026-05-12 |
| Effects of Ublituximab on Motor Functions in Multiple Sclerosis Ublituximab - Multiple Sclerosis (MS) - Relapsing-remitting | Early Phase 1 | Recruiting | Georgia State University | 25 | 2025-11-13 | 2026-02-09 |
| Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases UCAR T-cell - Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis | Early Phase 1 | Recruiting | Tianjin Huanhu Hospital | 12 | 2025-06-17 | 2025-12-15 |
| Assessment of Synaptic Density in MS [F-18]SDM-8 - Multiple Sclerosis | Early Phase 1 | Recruiting | Brigham and Women's Hospital | 30 | 2025-05-14 | 2026-01-09 |
| Universal CAR-T Cells in Patients with Refractory Autoimmune Diseases of the Nervous System. Universal BCMA CAR-T, Universal CD19 CAR-T, Universal BCMA CAR-T; Universal CD19 CAR-T - Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis, Generalized | Early Phase 1 | Not yet recruiting | Xuanwu Hospital, Beijing | 25 | 2025-02-28 | 2025-01-01 |
| Entire-body PET Scans for Multiple Sclerosis Entire-body PET-CT scans, Amyvid radiopharmaceutical - Multiple Sclerosis | Early Phase 1 | Recruiting | Brain Health Alliance | 20 | 2024-09-30 | 2026-10-06 |
| A Study of RD06-04 in Patients With Active Autoimmune Diseases RD06-04 cell infusion - SLE, Sclerosis | Early Phase 1 | Withdrawn | Nanjing Bioheng Biotech Co., Ltd. | 2024-08-31 | 2026-02-03 | |
| Study Evaluating the Safety of Myeliviz Myelin-Targeting PET Agent [11C]MeDAS - Healthy | Early Phase 1 | Withdrawn | Robert Fox | 2024-07-24 | 2025-02-17 | |
| Acute Effects of Walking Exercise on Brain Functioning in Multiple Sclerosis Moderate intensity walking exercise - Multiple Sclerosis | Early Phase 1 | Active not recruiting | Kessler Foundation | 24 | 2024-03-01 | 2026-08-06 |
| Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues Liraglutide Pen Injector [Saxenda], Medication Diary - Multiple Sclerosis, Long COVID | Early Phase 1 | Suspended | University of Chicago | 30 | 2024-01-26 | 2026-03-30 |
| Ketamine for MS Fatigue ketamine - Multiple Sclerosis | Early Phase 1 | Completed | Alta Bates Summit Medical Center | 21 | 2023-12-05 | 2025-06-08 |
Showing 20 of 43. Sign in to see all of them.
Multiple Sclerosis (30) · Neuromyelitis Optica (7) · Multiple Sclerosis, Relapsing-Remitting (6) · Myasthenia Gravis (5) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (5) · Multiple Sclerosis, Chronic Progressive (4) · Autoimmune Diseases of the Nervous System (3) · Autoimmune Diseases (2) · Leukoencephalopathy, Progressive Multifocal (2) · Motor Activity (2) · Recurrence (2) · Sclerosis (2) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (1) · Asphyxia Neonatorum (1)
Nervous System Diseases (43) · Immune System Diseases (39) · Autoimmune Diseases (37) · Demyelinating Autoimmune Diseases, CNS (37) · Autoimmune Diseases of the Nervous System (36) · Pathological Conditions, Signs and Symptoms (17) · Pathologic Processes (14) · Disease Attributes (12) · Chronic Disease (11) · Cranial Nerve Diseases (9) · Eye Diseases (8) · Optic Nerve Diseases (8) · Myelitis, Transverse (7) · Neuromuscular Diseases (7)
4-Aminopyridine (1) · Blood Specimen Collection (1) · Cyclophosphamide (1) · Ferrosoferric Oxide (1) · Gentamicins (1) · Interferon beta-1a (1) · Ketamine (1) · Liraglutide (1) · Melatonin (1) · Metformin (1) · Mycophenolic Acid (1) · N-methyl-4,4'-diaminostilbene (1) · Palliative Care (1) · Plasma Exchange (1) · Saline Solution (1)
Daishi Tian (2) · Griffin Hospital (2) · Kessler Foundation (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Tianjin Huanhu Hospital (2) · Tongji Hospital (2) · Aaron Boster (1) · Alta Bates Summit Medical Center (1) · Biocells Medical (1) · Biogen (1) · Brain Health Alliance (1) · Brigham and Women's Hospital (1) · Centre Hospitalier Universitaire de Nīmes (1) · Chinese PLA General Hospital (1) · Cook, Stuart, MD (1)
United States (19) · China (12) · Italy (2) · Argentina (1) · Austria (1) · Canada (1) · France (1) · Mexico (1) · Poland (1)
Frederick Browne, MD (2) · Irene CM Cortese, M.D. (2) · Joseph B Guarnaccia, MD (2) · Aaron L Boster, MD (1) · Adam DuVall, MD (1) · Amanda Garver, DO (1) · Antonio Fiaschi, Professor (1) · Carl Taswell, MD, PhD (1) · Chuan Qin, Prof. (1) · Daishi Tian, Ph.D. (1) · Daishi Tian, Prof. (1) · Deepak Soneji, MD (1) · Donovan Adendorf, DC (1) · Fu-Dong Shi, MD,PhD (1) · Fudong Shi, MD (1)
PMID 15824337, PMID 17409388, PMID 19737850, PMID 22935407, PMID 24963407, PMID 25583852, PMID 26774513, PMID 29464379, PMID 30312839, PMID 31741743, PMID 32633662, PMID 33242419, PMID 34302788, PMID 35355991, PMID 37658205, PMID 39126937, PMID 40319416, PMID 40425008, PMID 41101309, PMID 42079612
UL1TR002538 (1)