59 completed, 50 recruiting, 28 unknown, 18 not yet recruiting. 42 Phase 2, 33 Phase 1, 27 Phase 3, 22 Not applicable, 11 Phase 4.
Follow Myelitis, Transverse: new trials by email Literature Review of Myelitis, Transverse trials Research Report on Myelitis, Transverse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy UPLIZNA - Neuromyelitis Optica Spectrum Disorder, Pregnancy Related | Recruiting | Amgen | 60 | 2027-01-15 | 2026-10-29 | |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Safety and Efficacy of BAFFR CART for Relapsed/ Refractory Neuromyelitis Optica Spectrum Disorder Anti-BAFFR CART - Neuromyelitis Optica Spectrum Disorder | Phase 1 / Phase 2 | Not yet recruiting | Tianjin Medical University General Hospital | 20 | 2026-12-01 | 2026-10-16 |
| A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease CTX112 - Progressive Multiple Sclerosis (PMS), Neuromyelitis Optica | Phase 1 / Phase 2 | Not yet recruiting | CRISPR Therapeutics | 220 | 2026-11-01 | 2026-10-22 |
| Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health Blood sampling and multi-omic profiling - Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder | Not applicable | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 500 | 2026-11-01 | 2026-11-04 |
| Pattern of AFP in Chhidren Admitted at Sohag University Hospital Observitional follow-up - Acute Flaccid Paralysis, AFP | Not yet recruiting | Mohamed Aboelhamd Ali | 30 | 2026-09-01 | 2026-09-11 | |
| Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool No Intervention: Observational Cohort - Optic Neuritis, Multiple Sclerosis | Not yet recruiting | King's College London | 180 | 2026-09-01 | 2026-07-15 | |
| Efficacy and Safety of Low-Dose IL-2 in Neuromyelitis Optica Spectrum Disorder Placebo, IL-2 (interleukin 2) - Neuromyelitis Optica Spectrum Disorder (NMOSD) | Phase 2 | Not yet recruiting | Peking University People's Hospital | 60 | 2026-08-30 | 2026-09-09 |
| Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Study of Ravulizumab in Chinese Adults With Neuromyelitis Optica Spectrum Disorder (NMOSD) Ravulizumab - NMOSD, Neuromyelitis Optica Spectrum Disorder | Phase 3 | Recruiting | Alexion Pharmaceuticals, Inc. | 19 | 2026-07-20 | 2026-09-11 |
| A Multicenter Prospective Real-World Effectiveness and Safety of Satralizumab in the Early Treatment of Attacks in NMOSD Satralizumab - Neuromyelitis Optica Spectrum Disorders (NMOSD) | Recruiting | Junwei Hao, MD | 50 | 2026-07-20 | 2026-08-13 | |
| A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy CD20/BCMA-directed CAR-T cells Autologous 2nd generation - Multiple Sclerosis (MS), Myasthenia Gravis (MG) | Phase 1 | Not yet recruiting | The Affiliated Hospital of Qingdao University | 18 | 2026-07-01 | 2026-06-30 |
| Crisugabalin in NMOSD Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial Crisugabalin, Placebo+Crisugabalin - Neuromyelitis Optica Spectrum Disorders (NMOSD), Neuropathic Pain | Phase 4 | Not yet recruiting | Tang-Du Hospital | 110 | 2026-06-15 | 2026-07-13 |
| The Safety and Efficacy of KSVCBD Injection in Neuromyelitis Optica Spectrum Disorder. KSVCBD injection - Neuromyelitis Optica Spectrum Disease (NMOSD) | Early Phase 1 | Not yet recruiting | Chinese PLA General Hospital | 18 | 2026-05-15 | 2026-05-18 |
| A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and Pharmacodynamics of Satralizumab in Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD) Satralizumab - Neuromyelitis Optica Spectrum Disorder, NMOSD | Phase 3 | Recruiting | Hoffmann-La Roche | 8 | 2026-05-06 | 2026-10-01 |
| Anticipating Irreversible Disability in Neuromyelitis Optica Spectrum Disorder: a Study to Assess Disease Activity in Apparently Stable Patients MRI, Immunological Factors - Neuromyelitis Optica Spectrum Disorders | Not yet recruiting | IRCCS San Raffaele | 50 | 2026-04-01 | 2026-04-13 | |
| Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases. Universal CD19 CAR-γδT Cell Injection, Cyclophosphamide, Fludarabine - Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD) | Phase 1 | Recruiting | Tongji Hospital | 6 | 2026-04-01 | 2026-05-12 |
| Tongji NADs Cohort No active interventions - Multiple Sclerosis, NMO Spectrum Disorder | Not yet recruiting | Tongji Hospital | 1550 | 2026-03-01 | 2026-01-21 | |
| Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/ BCMA（QT-019C） in Patients With r/ r Neurological Autoimmune Diseases QT-019C - Neuromyelitis Optica Spectrum Disorders, Multiple Sclerosis | Early Phase 1 | Not yet recruiting | Tianjin Huanhu Hospital | 15 | 2026-03-01 | 2026-02-11 |
| A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy CD20/BCMA-directed CAR-T cells - Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) | Phase 1 | Not yet recruiting | Huashan Hospital | 15 | 2026-02-01 | 2026-01-15 |
| Therapy in the Acute Phase of NMOSD: A Multicenter Prospective Real-World Study Eculizumab+IVMP, IVIG+IVMP, IVMP - Neuromyelitis Optica Spectrum Disorder Attack | Phase 4 | Recruiting | Chinese PLA General Hospital | 200 | 2026-02-01 | 2026-03-12 |
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Neuromyelitis Optica (172) · Multiple Sclerosis (59) · Optic Neuritis (19) · Myasthenia Gravis (18) · Autoimmune Diseases of the Nervous System (16) · Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (16) · Demyelinating Diseases (11) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (11) · Encephalomyelitis, Acute Disseminated (10) · Autoimmune Diseases (8) · Myositis (6) · Recurrence (6) · Spinal Cord Injuries (6) · Demyelinating Autoimmune Diseases, CNS (5)
Immune System Diseases (188) · Nervous System Diseases (186) · Demyelinating Autoimmune Diseases, CNS (184) · Autoimmune Diseases (181) · Demyelinating Diseases (178) · Cranial Nerve Diseases (174) · Autoimmune Diseases of the Nervous System (173) · Eye Diseases (173) · Optic Nerve Diseases (172) · Optic Neuritis (155) · Neurodegenerative Diseases (51) · Neoplasms (49) · Neoplasms by Site (49) · Nervous System Neoplasms (49)
inebilizumab (8) · Rituximab (7) · eculizumab (7) · satralizumab (7) · Azathioprine (6) · Methylprednisolone (6) · Cyclophosphamide (5) · ravulizumab (5) · Blood Specimen Collection (4) · Immunoglobulins, Intravenous (4) · Mycophenolic Acid (4) · Adrenal Cortex Hormones (3) · Antilymphocyte Serum (3) · Methylprednisolone Hemisuccinate (3) · Plasma Exchange (3)
Tianjin Medical University General Hospital (14) · Alexion Pharmaceuticals, Inc. (9) · Tongji Hospital (7) · Hoffmann-La Roche (5) · Third Affiliated Hospital, Sun Yat-Sen University (5) · University of Texas Southwestern Medical Center (5) · Xuanwu Hospital, Beijing (5) · Beijing Tiantan Hospital (4) · Chinese PLA General Hospital (4) · Hospices Civils de Lyon (4) · Johns Hopkins University (4) · Mayo Clinic (4) · Tang-Du Hospital (4) · Amgen (3) · Assiut University (3)
China (70) · United States (64) · France (19) · Italy (17) · United Kingdom (14) · Canada (13) · Germany (13) · South Korea (12) · Spain (11) · Japan (10) · Poland (10) · Turkey (Türkiye) (10) · Russia (6) · Taiwan (6) · Argentina (5)
Michael Levy, MD, PhD (7) · Fu-Dong Shi, MD,PhD (4) · Benjamin Greenberg, MD (3) · Junwei Hao, MD (3) · Wei Wang, MD (3) · Chao Quan, Doctor (2) · Dai-shi Tian, MD (2) · Jagannadha Avasarala, MD PhD (2) · Jeffrey Weiss, MD (2) · Jinzhou Feng, Ph.D (2) · Richard Burt, MD (2) · Steven Levy, MD (2) · Wei Qiu (2)
PMID 40743487, PMID 26199618, PMID 26604914, PMID 27857759, PMID 27904503, PMID 33676197, PMID 34498507, PMID 36007339, PMID 36724181, PMID 40288333, PMID 10625901, PMID 11459743, PMID 12236201, PMID 12691631, PMID 16638802, PMID 16831964, PMID 18256991, PMID 19252779, PMID 19752302, PMID 20035902, PMID 20818891, PMID 22589446, PMID 23186897, PMID 23568718, PMID 23623397, PMID 2375246, PMID 23764350, PMID 23892551, PMID 24871874, PMID 25191939, PMID 25199960, PMID 26009577, PMID 26083135, PMID 26092914, PMID 26666258, PMID 28639937, PMID 28831548, PMID 29270420, PMID 29275977, PMID 29686116, PMID 30050918, PMID 30258442, PMID 30426289, PMID 30622896, PMID 30679041, PMID 31050279, PMID 31119146, PMID 31495497, PMID 31620478, PMID 31774956
2019 (4), 2014 (2), 2023 (2), 2008 (1), 2015 (1)