55 completed. 55 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 55 | Completed 55 |
Follow Cystic Fibrosis: new trials by email Literature Review of Cystic Fibrosis trials Research Report on Cystic Fibrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of Stopping Pancreatic Enzyme Replacement Therapy in Children With Improved Pancreatic Function After Highly Effective Modulator Therapy Discontinuation of Pancreatic Enzyme Replacement Therapy - Cystic Fibrosis (CF), Pancreatic Insufficiency | Phase 4 | Completed | Indiana University | 17 | 2024-12-03 | 2026-07-02 |
| Inhaled Mannitol on Mucociliary Clearance in Moderate to Severe Cystic Fibrosis Mannitol Inhalant Product - Cystic Fibrosis | Phase 4 | Completed | University of North Carolina, Chapel Hill | 14 | 2023-03-28 | 2026-01-07 |
| Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF Cholecalciferol Pill - Vitamin D Deficiency, Cystic Fibrosis | Phase 4 | Completed | Hospital Infantil de Mexico Federico Gomez | 40 | 2022-06-22 | 2025-04-08 |
| Cefiderocol Pharmacokinetics in Adult Patients With Cystic Fibrosis Cefiderocol - Cystic Fibrosis, Pneumonia, Bacterial | Phase 4 | Completed | Hartford Hospital | 10 | 2022-06-01 | 2024-12-16 |
| Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon CREON - Cystic Fibrosis, Chronic Pancreatitis | Phase 4 | Completed | AbbVie | 30 | 2021-10-14 | 2024-07-23 |
| Pharmacokinetics of Omadacycline in Cystic Fibrosis Omadacycline Injection [Nuzyra], Omadacycline Oral Tablet [Nuzyra] - Cystic Fibrosis | Phase 4 | Completed | Paul Beringer | 9 | 2021-07-01 | 2026-05-08 |
| Vitamin D and Prebiotics for Intestinal Health in Cystic Fibrosis Vitamin D3, Placebo vitamin D3, Inulin - Cystic Fibrosis, Dysbiosis | Phase 4 | Completed | Emory University | 40 | 2020-03-13 | 2024-02-07 |
| Hyperpolarized Imaging for New Treatments Initiation of CFTR Modulator - Cystic Fibrosis | Phase 4 | Completed | Children's Hospital Medical Center, Cincinnati | 47 | 2020-01-13 | 2026-10-07 |
| Cystic Fibrosis and Gut Dysmotility: The Effect of Polyethylene Glycol (PEG) on Intestinal Transit Polyethylene Glycol 3350, SmartPill Motility System & PillCam Patency Capsule - Cystic Fibrosis Gastrointestinal Disease | Phase 4 | Completed | St. Louis University | 3 | 2019-12-12 | 2024-08-09 |
| A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Pancrelipase - Cystic Fibrosis | Phase 4 | Completed | AbbVie | 36 | 2019-10-23 | 2023-09-28 |
| Intravenous Iron in Adults With Cystic Fibrosis Ferric carboxymaltose - Cystic Fibrosis, Iron-deficiency | Phase 4 | Completed | University of Oxford | 20 | 2019-02-22 | 2022-09-07 |
| Human Factors Study to Validate the User Interface of TOBI Podhaler Using Placebo Capsules Placebo, Tobi Podhaler - Cystic Fibrosis | Phase 4 | Completed | Mylan Inc. | 47 | 2018-06-26 | 2022-03-03 |
| Telavancin Pharmacokinetics in Cystic Fibrosis Patients Telavancin Injection - Cystic Fibrosis | Phase 4 | Completed | Joseph L. Kuti, PharmD | 18 | 2017-08-08 | 2019-10-24 |
| Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations Ivacaftor/Ataluren - Cystic Fibrosis | Phase 4 | Completed | University of Alabama at Birmingham | 1 | 2017-03-17 | 2019-07-19 |
| PTC Study to Evaluate Ataluren in Combination With Ivacaftor Ataluren - Cystic Fibrosis | Phase 4 | Completed | University of Alabama at Birmingham | 1 | 2017-01-27 | 2020-03-26 |
| Aztreonam for Inhalation Solution (AZLI) for the Treatment of Exacerbations of Cystic Fibrosis Aztreonam, Standard Care - Cystic Fibrosis, Infection | Phase 4 | Completed | Liverpool Heart and Chest Hospital NHS Foundation Trust | 16 | 2017-01-01 | 2019-10-07 |
| Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF) azithromycin, placebo (for azithromycin), inhaled tobramycin - Cystic Fibrosis | Phase 4 | Completed | Seattle Children's Hospital | 119 | 2016-10-21 | 2021-06-28 |
| EASY: Extended Access to Sollpura Over Years Liprotamase - Exocrine Pancreatic Insufficiency, Cystic Fibrosis | Phase 4 | Completed | Anthera Pharmaceuticals | 25 | 2016-09-01 | 2018-05-17 |
| A Study of the Effects of Lumacaftor/Ivacaftor (LUM/IVA) on Exercise Tolerance in Subjects With Cystic Fibrosis (CF), Homozygous for the F508del-CFTR Mutation LUM/IVA, Placebo - Cystic Fibrosis | Phase 4 | Completed | Vertex Pharmaceuticals Incorporated | 70 | 2016-09-01 | 2019-06-17 |
| IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy Colistin, Tobramycin - Cystic Fibrosis | Phase 4 | Completed | National Jewish Health | 51 | 2016-08-26 | 2026-04-28 |
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Exocrine Pancreatic Insufficiency (8) · Pseudomonas Infections (5) · Bone Diseases, Metabolic (2) · Osteoporosis (2) · Pneumonia (2) · Anemia, Iron-Deficiency (1) · Avitaminosis (1) · Dysbiosis (1) · Fibroadenoma (1) · Fibrocystic Breast Disease (1) · Glucose Intolerance (1) · Glucose Metabolism Disorders (1) · Infections (1) · Lung Diseases (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (55) · Digestive System Diseases (55) · Genetic Diseases, Inborn (55) · Infant, Newborn, Diseases (55) · Respiratory Tract Diseases (55) · Lung Diseases (54) · Pancreatic Diseases (54) · Nutritional and Metabolic Diseases (7) · Bacterial Infections (6) · Bacterial Infections and Mycoses (6) · Infections (6) · Metabolic Diseases (6) · Gram-Negative Bacterial Infections (5) · Pathological Conditions, Signs and Symptoms (4) · Bone Diseases (3)
Pancrelipase (4) · Azithromycin (3) · Cholecalciferol (3) · dornase alfa (3) · Alendronate (2) · Tobramycin (2) · ataluren (2) · Aztreonam (1) · Cefiderocol (1) · Chest Wall Oscillation (1) · Ciprofloxacin (1) · Colistin (1) · Doxycycline (1) · Influenza Vaccines (1) · Insulin Glargine (1)
Forest Laboratories (3) · Novartis Pharmaceuticals (3) · University of Southern California (3) · AbbVie (2) · Assistance Publique - Hôpitaux de Paris (2) · Emory University (2) · Joseph L. Kuti, PharmD (2) · University of Alabama at Birmingham (2) · Adelaida Lamas Ferreiro (1) · Anthera Pharmaceuticals (1) · Azienda Policlinico Umberto I (1) · CF Therapeutics Development Network Coordinating Center (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Chris Goss (1)
United States (31) · Canada (8) · United Kingdom (5) · France (4) · Italy (4) · Spain (4) · Germany (3) · Australia (2) · Hungary (2) · Mexico (2) · Poland (2) · Argentina (1) · Belgium (1) · Czechia (1) · Denmark (1)
Joseph L Kuti, PharmD (3) · Felix Ratjen, MD (2) · Steven M Rowe, MD (2) · Adelaida Lamas, MD (1) · Adriana Franzese, Dr (1) · Adupa P Rao, M.D. (1) · Alan Smyth (1) · Alexandra Papaioannou, M.D. (1) · Andreas Freitag, M.D. (1) · Anne Munck, MD (1) · Chris Goss, MD (1)
PMID 33735508, PMID 12791627, PMID 14717616, PMID 15319624, PMID 1550069, PMID 16123520, PMID 16627012, PMID 18641106, PMID 19821321, PMID 20442386, PMID 20507651, PMID 20693248, PMID 22024822, PMID 22399505, PMID 22506011, PMID 22563440, PMID 22595153, PMID 22746323, PMID 22805498, PMID 24121143, PMID 24891257, PMID 24950362, PMID 25921451, PMID 26282839, PMID 26416780, PMID 26830335, PMID 26903303, PMID 27144634, PMID 27313953, PMID 27435882, PMID 27550351, PMID 28614995, PMID 28784670, PMID 28986022, PMID 31685468, PMID 33358119, PMID 33358691, PMID 34159577, PMID 34469706, PMID 34933824, PMID 35300932, PMID 36625789, PMID 37963297, PMID 38096105, PMID 39581957, PMID 8125859
2009 (1), 2016 (1), 2017 (1), R01HL124053 (1)