7 completed, 4 unknown, 2 recruiting, 1 not yet recruiting. 15 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Completed 7, Unknown 4, Recruiting 2, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 3 | Recruiting 2, Unknown 1 |
Follow Cryptococcosis: new trials by email Literature Review of Cryptococcosis trials Research Report on Cryptococcosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2 - Hiv, Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | David Boulware | 2000 | 2025-05-28 | 2026-07-27 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3 MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 3 | Unknown | Matinas BioPharma Nanotechnologies, Inc. | 270 | 2023-01-01 | 2022-09-15 |
| AmB Dose for Cryptococcal Meningitis Amphotericin B, Flucytosine - Cryptococcal Meningitis, HIV Infections | Phase 3 | Unknown | Shanghai Public Health Clinical Center | 40 | 2020-01-02 | 2019-10-29 |
| Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Single dose liposomal Amphotericin and Fluconazole, Fluconazole - Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | Makerere University | 356 | 2019-06-20 | 2026-04-28 |
| Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis AK1820, Voriconazole - Deep Mycosis | Phase 3 | Completed | Asahi Kasei Therapeutics Corporation | 103 | 2018-04-16 | 2021-05-14 |
| Cryptococcal Antigen Screening Plus Sertraline Sertraline, Placebo Oral Tablet, Fluconazole - Cryptococcosis, Cryptococcal Infections | Phase 3 | Terminated | University of Minnesota | 22 | 2017-11-15 | 2020-06-09 |
| Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Sertraline - Cryptococcal Meningitis, Fungal Meningitis | Phase 3 | Completed | University of Minnesota | 460 | 2015-03-09 | 2020-06-09 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics) - Neurological Disorders, Cerebral Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 352 | 2012-09-01 | 2016-01-18 |
| Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Fluconazole, Flucytosine, lumbar punctures - Cryptococcal Meningitis, HIV | Phase 2 / Phase 3 | Unknown | ANRS, Emerging Infectious Diseases | 41 | 2012-05-01 | 2016-07-12 |
| Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis SPK-843 - Cryptococcosis or Aspergillosis Infections | Phase 3 | Unknown | Proaparts srl | 10 | 2010-05-01 | 2011-06-08 |
| A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection ITCZ Oral Solution, ITCZ-IV - Mycoses, Candidiasis | Phase 3 | Completed | Janssen Pharmaceutical K.K. | 55 | 2008-01-01 | 2013-07-25 |
| Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Posaconazole oral suspension - Mycoses | Phase 3 | Completed | Merck Sharp & Dohme LLC | 2001-04-01 | 2017-03-10 | |
| Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Posaconazole - Mycoses | Phase 3 | Completed | Merck Sharp & Dohme LLC | 336 | 1998-12-01 | 2017-03-10 |
| Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS Fluconazole, Amphotericin B - Meningitis, Cryptococcal, HIV Infections | Phase 3 | Completed | Pfizer | 330 | 2011-03-14 |
Meningitis, Cryptococcal (9) · Aspergillosis (4) · Candidiasis (3) · HIV Infections (3) · Mycoses (3) · AIDS-Related Opportunistic Infections (2) · Acquired Immunodeficiency Syndrome (2) · Meningitis (2) · Blastomycosis (1) · Histoplasmosis (1) · Invasive Fungal Infections (1) · Malaria, Cerebral (1) · Meningitis, Bacterial (1) · Meningitis, Fungal (1)
Bacterial Infections and Mycoses (15) · Infections (15) · Mycoses (12) · Central Nervous System Diseases (9) · Central Nervous System Fungal Infections (9) · Central Nervous System Infections (9) · Neuroinflammatory Diseases (9) · Meningitis, Fungal (8) · Nervous System Diseases (8) · Meningitis (7) · Blood-Borne Infections (5) · Communicable Diseases (5) · Immune System Diseases (5) · Immunologic Deficiency Syndromes (5)
Fluconazole (5) · Amphotericin B (4) · Flucytosine (2) · Sertraline (2) · Antiretroviral Therapy, Highly Active (1) · SPA S 843 (1) · Spinal Puncture (1) · Standard of Care (1) · Voriconazole (1) · isavuconazole (1) · liposomal amphotericin B (1) · posaconazole (1)
University of Minnesota (3) · Merck Sharp & Dohme LLC (2) · ANRS, Emerging Infectious Diseases (1) · Asahi Kasei Therapeutics Corporation (1) · David Boulware (1) · Institute of Tropical Medicine, Belgium (1) · Janssen Pharmaceutical K.K. (1) · Makerere University (1) · Matinas BioPharma Nanotechnologies, Inc. (1) · Pfizer (1) · Proaparts srl (1) · Shanghai Public Health Clinical Center (1)
Uganda (5) · Japan (2) · Burundi (1) · China (1) · Côte d’Ivoire (1) · Democratic Republic of the Congo (1) · Italy (1) · United States (1)
Radha Rajasingham, MD (2) · Armstrong D (1) · David B Meya, MBCHB MMed (1) · David B Meya, MBChB (1) · David B Meya, MBChB, MMed, PhD (1) · David R Boulware, MD (1) · David R Boulware, MD MPH (1) · David R Boulware, MD, MPH (1) · Dismukes W (1) · Elizabeth K Nalintya, MBChB MPH (1) · Emmanuel Bottieau, MD (1) · Francesco Blasi, MD (1) · Joshua Rhein, MD (1)
PMID 18813103, PMID 19485785, PMID 30256903, PMID 30325463, PMID 30345376, PMID 31242860, PMID 31345462, PMID 32415846, PMID 32843994, PMID 33677986, PMID 35191210, PMID 36303432, PMID 36307059, PMID 38152404, PMID 39044381, PMID 39972326
R01NS086312 (1), U01AI125003 (1)