3 unknown, 2 completed, 2 recruiting, 1 not yet recruiting. 8 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Unknown 3, Completed 2, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 3 | Recruiting 2, Unknown 1 |
Follow Cryptococcal Meningitis: new trials by email Literature Review of Cryptococcal Meningitis trials Research Report on Cryptococcal Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2 - Hiv, Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | David Boulware | 2000 | 2025-05-28 | 2026-07-27 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3 MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 3 | Unknown | Matinas BioPharma Nanotechnologies, Inc. | 270 | 2023-01-01 | 2022-09-15 |
| AmB Dose for Cryptococcal Meningitis Amphotericin B, Flucytosine - Cryptococcal Meningitis, HIV Infections | Phase 3 | Unknown | Shanghai Public Health Clinical Center | 40 | 2020-01-02 | 2019-10-29 |
| Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Single dose liposomal Amphotericin and Fluconazole, Fluconazole - Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | Makerere University | 356 | 2019-06-20 | 2026-04-28 |
| Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Sertraline - Cryptococcal Meningitis, Fungal Meningitis | Phase 3 | Completed | University of Minnesota | 460 | 2015-03-09 | 2020-06-09 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics) - Neurological Disorders, Cerebral Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 352 | 2012-09-01 | 2016-01-18 |
| Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Fluconazole, Flucytosine, lumbar punctures - Cryptococcal Meningitis, HIV | Phase 2 / Phase 3 | Unknown | ANRS, Emerging Infectious Diseases | 41 | 2012-05-01 | 2016-07-12 |
Meningitis, Cryptococcal (8) · HIV Infections (2) · Acquired Immunodeficiency Syndrome (1) · Malaria, Cerebral (1) · Meningitis (1) · Meningitis, Bacterial (1) · Meningitis, Fungal (1) · Neglected Diseases (1) · Nervous System Diseases (1) · Neurosyphilis (1) · Tuberculosis, Central Nervous System (1)
Bacterial Infections and Mycoses (8) · Central Nervous System Diseases (8) · Central Nervous System Fungal Infections (8) · Central Nervous System Infections (8) · Cryptococcosis (8) · Infections (8) · Mycoses (8) · Neuroinflammatory Diseases (8) · Meningitis (7) · Meningitis, Fungal (7) · Nervous System Diseases (7) · Blood-Borne Infections (3) · Communicable Diseases (3) · Genital Diseases (3) · Immune System Diseases (3)
Amphotericin B (3) · Fluconazole (3) · Flucytosine (2) · Antiretroviral Therapy, Highly Active (1) · Sertraline (1) · Spinal Puncture (1) · Standard of Care (1) · liposomal amphotericin B (1)
University of Minnesota (2) · ANRS, Emerging Infectious Diseases (1) · David Boulware (1) · Institute of Tropical Medicine, Belgium (1) · Makerere University (1) · Matinas BioPharma Nanotechnologies, Inc. (1) · Shanghai Public Health Clinical Center (1)
Uganda (4) · Burundi (1) · China (1) · Côte d’Ivoire (1) · Democratic Republic of the Congo (1)
David B Meya, MBCHB MMed (1) · David B Meya, MBChB (1) · David B Meya, MBChB, MMed, PhD (1) · David R Boulware, MD (1) · David R Boulware, MD MPH (1) · David R Boulware, MD, MPH (1) · Emmanuel Bottieau, MD (1) · Joshua Rhein, MD (1) · Marleen Boelaert, MD, PhD (1) · Olivier Bouchaud, PhD (1) · Radha Rajasingham, MD (1)
PMID 30256903, PMID 30325463, PMID 30345376, PMID 31242860, PMID 31345462, PMID 32843994, PMID 33677986, PMID 36303432, PMID 38152404, PMID 39044381, PMID 39972326
R01NS086312 (1)