4 completed, 2 recruiting, 2 terminated, 1 unknown. 9 Phase 2, 3 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 4, Recruiting 2, Terminated 2, Unknown 1 |
| Phase 3 | 3 | Recruiting 2, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow Cryptococcal Meningitis: new trials by email Literature Review of Cryptococcal Meningitis trials Research Report on Cryptococcal Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Platform Trial For Cryptococcal Meningitis (PLATFORM-CM) Standard of care, Oteseconazole - antifungal therapy 1, Turletricin injection - antifungal therapy 2 - Hiv, Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | David Boulware | 2000 | 2025-05-28 | 2026-07-27 |
| Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis AMBITION trial control, Flucytosine - Cryptococcal Meningitis | Phase 2 | Completed | University of Minnesota | 48 | 2024-04-09 | 2025-08-27 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 1 / Phase 2 | Completed | Matinas BioPharma Nanotechnologies, Inc. | 178 | 2019-10-24 | 2023-03-31 |
| Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Single dose liposomal Amphotericin and Fluconazole, Fluconazole - Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | Makerere University | 356 | 2019-06-20 | 2026-04-28 |
| Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Fluconazole, Flucytosine, lumbar punctures - Cryptococcal Meningitis, HIV | Phase 2 / Phase 3 | Unknown | ANRS, Emerging Infectious Diseases | 41 | 2012-05-01 | 2016-07-12 |
| High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Fluconazole, Amphotericin B - Cryptococcal Meningitis, HIV Infections | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 168 | 2010-04-16 | 2021-11-04 |
| Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Mycograb, placebo - Cryptococcal Meningitis | Phase 2 | Terminated | Novartis Pharmaceuticals | 3 | 2007-03-01 | 2008-12-12 |
| Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Efungumab (Mycograb), placebo, Amphotericin B - Cryptococcal Meningitis | Phase 2 | Terminated | Novartis Pharmaceuticals | 38 | 2006-08-01 | 2009-02-19 |
| Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis Amphotericin B, Fluconazole - Cryptococcal Meningitis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 143 | 2005-05-01 | 2012-05-16 |
Meningitis, Cryptococcal (9) · HIV Infections (3) · Acquired Immunodeficiency Syndrome (1) · Bacterial Infections (1) · Meningitis (1)
Bacterial Infections and Mycoses (9) · Central Nervous System Diseases (9) · Central Nervous System Fungal Infections (9) · Central Nervous System Infections (9) · Cryptococcosis (9) · Infections (9) · Meningitis, Fungal (9) · Mycoses (9) · Nervous System Diseases (9) · Neuroinflammatory Diseases (9) · Meningitis (8) · Blood-Borne Infections (4) · Communicable Diseases (4) · Genital Diseases (4) · Immune System Diseases (4)
Amphotericin B (5) · Fluconazole (4) · Flucytosine (3) · efungumab (2) · liposomal amphotericin B (2) · Spinal Puncture (1) · Standard of Care (1) · amphotericin B, deoxycholate drug combination (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · Novartis Pharmaceuticals (2) · ANRS, Emerging Infectious Diseases (1) · David Boulware (1) · Makerere University (1) · Matinas BioPharma Nanotechnologies, Inc. (1) · University of Minnesota (1)
Uganda (5) · United States (3) · South Africa (2) · Thailand (2) · Burundi (1) · Côte d’Ivoire (1) · India (1) · Kenya (1) · Peru (1) · Zimbabwe (1)
David B Meya (1) · David B Meya, MBChB, MMed, PhD (1) · David R Boulware (1) · David R Boulware, MD, MPH (1) · Olivier Bouchaud, PhD (1) · Robert A. Larsen, MD (1) · Umesh G. Lalloo, MD, FRCP (1)
PMID 19441980, PMID 19897055, PMID 32747357, PMID 36780493, PMID 37606364, PMID 38943665, PMID 39044381, PMID 39972326, PMID 40665233, PMID 40795226