6 completed, 3 unknown, 1 recruiting, 1 terminated. 11 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 6, Unknown 3, Recruiting 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow COPD Exacerbation: new trials by email Literature Review of COPD Exacerbation trials Research Report on COPD Exacerbation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease Supported rescue pack - COPD, COPD Exacerbation | Phase 3 | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 1400 | 2025-01-30 | 2025-02-10 |
| The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation Furosemide, Normal saline - Chronic Obstructive Pulmonary Disease Exacerbation, COPD Exacerbation | Phase 3 | Unknown | American University of Beirut Medical Center | 200 | 2023-03-01 | 2023-03-15 |
| A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD Beclomethasone Dipropionate, Glycopyrronium Bromide, Formoterol Fumarate - COPD, COPD Exacerbation | Phase 3 | Completed | Chiesi Farmaceutici S.p.A. | 3406 | 2022-04-27 | 2026-09-21 |
| Inhaled Amikacin in Preventing AECOPD aerosol inhaled Amikacin Sulfate Injection, conventional therapy - COPD, COPD Exacerbation | Phase 3 | Unknown | Shanghai Zhongshan Hospital | 136 | 2022-03-01 | 2022-02-23 |
| Eosinophil-driven Corticotherapy for Patients Hospitalized for COPD Exacerbation 5 days of systemic corticotherapy (prednisone), 5 days of placebo - COPD Exacerbation | Phase 3 | Terminated | University Hospital, Montpellier | 182 | 2021-10-12 | 2026-06-12 |
| Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD Theophylline ER, Placebo oral tablet, Standard of Care Treatment - COPD, COPD Exacerbation | Phase 3 | Completed | University of Miami | 100 | 2021-02-23 | 2024-11-15 |
| Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease Varenicline, placebo - Chronic Obstructive Pulmonary Disease, COPD Exacerbation | Phase 3 | Completed | University Hospital, Brest | 83 | 2012-08-01 | 2016-02-11 |
| Evaluation of Utility Quadriceps Magnetic Stimulation in COPD (Chronic Obstructive Pulmonary Disease) Patients After Hospital Exacerbation Repetitive magnetic stimulation of the quadriceps muscle - COPD, COPD Exacerbation | Phase 3 | Unknown | Hospital de Cruces | 32 | 2011-01-01 | 2010-12-22 |
| Oral Prednisolone in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Prednisolone, usual care - COPD Exacerbation | Phase 3 | Completed | Fekri Abroug | 317 | 2010-04-01 | 2017-08-01 |
| TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial Prednisone, Etanercept, levofloxacin - COPD Exacerbation | Phase 2 / Phase 3 | Completed | Ottawa Hospital Research Institute | 81 | 2008-11-01 | 2016-04-11 |
| Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Ipratropium bromide, Magnesium Sulfate - COPD Exacerbation | Phase 3 | Completed | University of Monastir | 124 | 2005-01-01 | 2010-06-03 |
Pulmonary Disease, Chronic Obstructive (8) · Dyspnea (1) · Respiratory Tract Diseases (1) · Smoking (1) · Smoking Cessation (1)
Chronic Disease (8) · Disease Attributes (8) · Lung Diseases (8) · Lung Diseases, Obstructive (8) · Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Respiratory Tract Diseases (7) · Behavior (1) · Health Behavior (1) · Respiration Disorders (1) · Signs and Symptoms (1) · Signs and Symptoms, Respiratory (1)
Prednisone (2) · Beclomethasone (1) · Diuretics (1) · Etanercept (1) · Formoterol Fumarate (1) · Furosemide (1) · Glycopyrrolate (1) · Ipratropium (1) · Levofloxacin (1) · Magnesium Sulfate (1) · Prednisolone (1) · Saline Solution (1) · Theophylline (1) · Varenicline (1)
American University of Beirut Medical Center (1) · Chiesi Farmaceutici S.p.A. (1) · Fekri Abroug (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Hospital de Cruces (1) · Ottawa Hospital Research Institute (1) · Shanghai Zhongshan Hospital (1) · University Hospital, Brest (1) · University Hospital, Montpellier (1) · University of Miami (1) · University of Monastir (1)
France (2) · Tunisia (2) · Argentina (1) · Bulgaria (1) · Canada (1) · China (1) · Czechia (1) · Hungary (1) · Mexico (1) · Poland (1) · Puerto Rico (1) · Romania (1) · Spain (1) · Uganda (1) · United Kingdom (1)
Fekri Abroug, MD (1) · Hisham Bou Fakhreddine, MD (1) · Jing Zhang, MD, PhD (1) · Mona Bafadhel, Professor (1) · Nivine Abou Dargham, MD (1) · Salah Zeineddine, MD (1) · Shawn Aaron, MD, MSc (1) · Thomas Siler, MD (1) · Trishul Siddharthan, MD (1)
PMID 23161645, PMID 31854207, PMID 32611741, PMID 33726828, PMID 34611902
2019 (1), 2023 (1), K23HL146946 (1)