81 completed, 60 unknown, 15 recruiting, 14 terminated. 83 Not applicable, 14 Phase 4, 11 Phase 3, 4 Phase 2, 1 Phase 1.
Follow COPD Exacerbation: new trials by email Literature Review of COPD Exacerbation trials Research Report on COPD Exacerbation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Patients Presenting to the Emergency Department With Acute Exacerbation of COPD (ECOPD) Revefenacin, formoterol fumarate, Placebo (Sterile Normal Saline) - COPD Exacerbation | Phase 4 | Not yet recruiting | University of Tennessee Graduate School of Medicine | 280 | 2026-11-12 | 2026-10-19 |
| Combination of High-flow Nasal Oxygen (Optiflow) and Vibrating Membrane Nebuliser (Aerogen) in the Pre-hospital Setting - Before/After Study Vibrating membrane nebulizer and high-intensity nasal oxygen, nebulizer mask and oxygen therapy of 6 to 9 liters per minute - Hypercapnia, Asthma Exacerbation | Withdrawn | Centre Hospitalier Sud Francilien | 2026-10-01 | 2026-08-28 | ||
| A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD R-3750 - COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbation | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 27 | 2026-09-01 | 2026-01-29 |
| Early Detection of COPD Exacerbations Using Home Monitoring Device RespirAI - COPD Exacerbation | Recruiting | RespirAI US Inc | 30 | 2026-08-05 | 2026-08-10 | |
| Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD EmoD Intervention - COPD Exacerbation | Not applicable | Active not recruiting | University of Zurich | 20 | 2026-01-12 | 2026-06-16 |
| The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events NuvoAir clinical service - COPD Exacerbation, COPD | Not applicable | Not yet recruiting | NuvoAir Medical PC | 1050 | 2026-01-01 | 2025-05-28 |
| Study on Home Obstructive Respiratory Exacerbations RESP™ Biosensor - COPD Exacerbation, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection | Enrolling by invitation | Strados Labs, Inc. | 20 | 2025-12-05 | 2026-01-20 | |
| High-intensity Resistance Training in Post-exacerbation COPD HIRT, HIET - COPD Exacerbation | Not applicable | Recruiting | Istituti Clinici Scientifici Maugeri SpA | 64 | 2025-10-30 | 2025-12-24 |
| Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease Titrated Oxygen, Standard Oxygen - COPD Exacerbation, COPD Exacerbation Acute | Phase 4 | Recruiting | Central Denmark Region | 1888 | 2025-06-02 | 2026-10-02 |
| Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients Virtual at Home Medication Reconciliation Visit(s), Virtual At Home Medication Education Visit(s), COPD advanced practice nurse Inpatient Consult - COPD Exacerbation, Care Transitions | Not applicable | Enrolling by invitation | University of Chicago | 218 | 2025-02-19 | 2026-01-14 |
| Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease Supported rescue pack - COPD, COPD Exacerbation | Phase 3 | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 1400 | 2025-01-30 | 2025-02-10 |
| Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy. COPD, COPD Exacerbation | Not yet recruiting | University Hospital, Grenoble | 42 | 2025-01-01 | 2024-10-23 | |
| Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients Oral care - Nosocomial Pneumonia, COPD Exacerbation | Not applicable | Recruiting | Assiut University | 60 | 2024-10-01 | 2024-11-15 |
| The Effect of Stress Ball on COPD Patients Receiving Noninvasive Mechanical Ventilation Support stress ball - COPD, COPD Exacerbation | Not applicable | Completed | Kafkas University | 68 | 2024-06-15 | 2025-03-05 |
| Impulse Oscillometry in COPD Exacerbation Impulse Oscillometry - COPD Exacerbation, COPD | Completed | Deniz Bilici | 41 | 2024-03-01 | 2025-09-22 | |
| Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS) continuous positive airway pressure treatment - Sleep Apnea, COPD Exacerbation | Not applicable | Recruiting | University Hospital, Angers | 500 | 2024-01-09 | 2025-04-13 |
| Comfort of Patients Under Non Invasive Ventilation According to the Mask mask - COPD Exacerbation, Hypercapnia | Unknown | Assistance Publique - Hôpitaux de Paris | 80 | 2024-01-01 | 2024-01-18 | |
| A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Adolescent and Adult Patients in an Emergency Department ResAppDx v.20 - Asthma Exacerbation, COPD Exacerbation | Completed | ResApp Health Limited | 171 | 2024-01-01 | 2024-03-04 | |
| Exacerbantes Study COPD Exacerbation | Unknown | Sociedad Española de Neumología y Cirugía Torácica | 400 | 2023-12-31 | 2023-11-27 | |
| Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Non-invasive ventilation - COPD Exacerbation, COPD Exacerbation Acute | Not applicable | Unknown | Central Denmark Region | 140 | 2023-12-08 | 2024-01-18 |
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Pulmonary Disease, Chronic Obstructive (98) · Respiratory Insufficiency (8) · Pneumonia (7) · Hypoxia (5) · Heart Failure (4) · Hypercapnia (4) · Lymphoma, Follicular (4) · Motor Activity (4) · Asthma (3) · Bronchiectasis (3) · Dyspnea (3) · Emphysema (3) · Hyperoxia (3) · Inflammation (3) · Respiration Disorders (3)
Respiratory Tract Diseases (113) · Pathological Conditions, Signs and Symptoms (109) · Lung Diseases (105) · Lung Diseases, Obstructive (102) · Disease Attributes (100) · Pathologic Processes (100) · Chronic Disease (99) · Signs and Symptoms (19) · Signs and Symptoms, Respiratory (15) · Respiration Disorders (14) · Infections (12) · Respiratory Tract Infections (12) · Behavior (9) · Bronchial Diseases (7) · Immune System Diseases (7)
Formoterol Fumarate (6) · Exercise (3) · Ipratropium (3) · Blood Specimen Collection (2) · Data Collection (2) · Glycopyrrolate (2) · Levofloxacin (2) · Noninvasive Ventilation (2) · Prednisolone (2) · Prednisone (2) · Saline Solution (2) · Standard of Care (2) · Watchful Waiting (2) · revefenacin (2) · Acupuncture Therapy (1)
Assiut University (6) · University of Monastir (5) · China-Japan Friendship Hospital (4) · Laval University (4) · Universidad de Granada (4) · University of Tennessee Graduate School of Medicine (3) · AstraZeneca (2) · Bezmialem Vakif University (2) · Central Denmark Region (2) · Chronic Obstructive Pulmonary Disease Trial Network, Denmark (2) · Elpen Pharmaceutical Co. Inc. (2) · François Lellouche (2) · Groupe Hospitalier du Havre (2) · Guy's and St Thomas' NHS Foundation Trust (2) · Hospital Universitario Marqués de Valdecilla (2)
United States (25) · France (17) · United Kingdom (17) · Canada (11) · China (10) · Denmark (10) · Italy (10) · Spain (9) · Turkey (Türkiye) (9) · Netherlands (6) · Tunisia (6) · Germany (5) · Belgium (4) · Switzerland (4) · Argentina (3)
Qingyuan Zhan, M.D. (4) · Nouira Semir, Professor (2) · Roberto P Benzo, MD (2) · Adam D Wells, MD, FCCP (1) · Alda Marques, PhD (1) · Alyn H Morice, MD, MPhil (1) · Antoine Cuvelier, MD, PhD (1) · Apurv Soni, MD, PhD (1)
PMID 35514131, PMID 10377201, PMID 10856313, PMID 12448594, PMID 13331841, PMID 14680096, PMID 1568955, PMID 15994402, PMID 16120227, PMID 16840741, PMID 17391084, PMID 18708420, PMID 18760576, PMID 19017866, PMID 19720809, PMID 20040088, PMID 20205936, PMID 20407960, PMID 20959284, PMID 21115606, PMID 21174112, PMID 21354020, PMID 21481577, PMID 22348812, PMID 22481636, PMID 22693693, PMID 23161645, PMID 23338569, PMID 23391488, PMID 23806051, PMID 24914492, PMID 25230375, PMID 26530543, PMID 26647450, PMID 26756585, PMID 27585384, PMID 28128970, PMID 28353117, PMID 29071072, PMID 29145259, PMID 29362258, PMID 29579254, PMID 29763572, PMID 29857993, PMID 30319251, PMID 30545350, PMID 30683080, PMID 30774953, PMID 31331372, PMID 31387158
2019 (3), R61HL142933 (2), 2018 (1), 2023 (1), 2025 (1), K23HL146946 (1), R34HL117349 (1)