262 completed, 96 unknown, 76 recruiting, 34 terminated. 209 Not applicable, 42 Phase 2, 19 Phase 3, 17 Phase 1, 8 Phase 4.
Follow Congenital Heart Disease: new trials by email Literature Review of Congenital Heart Disease trials Research Report on Congenital Heart Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| TORCH-LATAM: A Regional Pathway to Improve Transplant Evaluation for Congenital Heart Disease TORCH Integrated Transplant Access Pathway (TORCH-ITAP) - Congenital Heart Disease | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 600 | 2027-03-01 | 2026-10-13 |
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Comparison of the Best Method for Measuring Anti-Xa Activity in Children Receiving Unfractionated Heparin in Cardiac Intensive Care (COMPAXE-HNF) blood sampling for measuring anti-Xa activity, measurement of anti-XA activity - Congenital Heart Disease, Unfractionated Heparin | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 22 | 2026-11-01 | 2026-09-21 |
| UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease UltraTrac - Congenital Heart Disease, Cardiac Output | Not applicable | Not yet recruiting | University of Minnesota | 70 | 2026-11-01 | 2026-10-08 |
| Echocardiographic Assessment of Valvular Dysfunction in Children With CHD Congenital Heart Disease, Valvular Heart Disease | Not yet recruiting | Assiut University | 100 | 2026-10-10 | 2026-10-08 | |
| The Effect of Telerehabilitation Exercises in Children With Congenital Heart Disease Inspiratory Muscle Training, Functional Inspiratory Muscle Training - Congenital Heart Disease, Telerehabilitation | Not applicable | Not yet recruiting | Izmir Democracy University | 32 | 2026-10-01 | 2026-10-02 |
| International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease Transcatheter pulmonary flow restriction - Congenital Heart Disease | Enrolling by invitation | Fondation Hôpital Saint-Joseph | 150 | 2026-10-01 | 2026-09-15 | |
| Localized Evidence of Cytokine Adsorption Therapy During Pediatric Cardiac Surgery: A Single Center Randomized Controlled Trial (LEAT) Hemoadsorption (Jafron HA-60/HA380) - Congenital Heart Disease, Open Heart Surgery | Not applicable | Not yet recruiting | Norfaniza Zabidi | 120 | 2026-10-01 | 2026-08-18 |
| Perinatal Cardiology: Bridging Obstetric and Neonatal Care in CHD Congenital Heart Disease, Fetal Heart Disorder | Not yet recruiting | Assiut University | 115 | 2026-09-02 | 2026-09-16 | |
| Exercise Prehabilitation in Congenital Heart Disease Exercise prehabilitation - Congenital Heart Disease, Cardiac Surgery | Not applicable | Recruiting | Liverpool Heart and Chest Hospital NHS Foundation Trust | 32 | 2026-08-28 | 2026-09-30 |
| Heart2Heart for Teens With CHD Heart2Heart - Congenital Heart Disease, Health Behavior | Not applicable | Enrolling by invitation | Kristen Fox | 90 | 2026-08-18 | 2026-08-19 |
| Screening for Disorders of Lipid Metabolism and Familial Hyperlipidemia in Children and Adolescents With Increased Cardiovascular Risk Due to Chronic Diseases Such as Congenital Heart Disease, Chronic Inflammatory Bowel Disease, Celiac Disease and Rheumatic Disorders blood test, questionaire - Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors | Not applicable | Recruiting | Alexandra Miriam Kiess | 600 | 2026-08-01 | 2026-07-21 |
| Observational Data Collection for Blood Hemoglobin Algorithm Validation in Pediatrics Noninvasive hemoglobin monitoring - Hemoglobin, Cerebral Oxygenation | Not yet recruiting | Boston Children's Hospital | 100 | 2026-08-01 | 2026-07-27 | |
| Tailored MgSO4 Supplementation to Reduce Complications in Pediatric Heart Surgery total magnesium, ionized magnesium - AKI - Acute Kidney Injury, Arrythmia | Not applicable | Not yet recruiting | West Virginia University | 96 | 2026-08-01 | 2026-06-16 |
| Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial Prospective Apple Watch Series 9 - Congenital Heart Disease, Pulmonary Hypertension | Not yet recruiting | The University of Hong Kong | 20 | 2026-08-01 | 2026-06-23 | |
| Comparison of Erector Spinae Plane Block and Modified Pectoral Fascial Plane Block for Postoperative Analgesia in Pediatric Cardiac Surgery Ultrasound-Guided Erector Spinae Plane Block, Ultrasound-Guided Modified Pectoral Fascial Plane Block - Congenital Heart Disease, Postoperative Pain After Cardiac Surgery Via Median Sternotomy | Not applicable | Completed | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 50 | 2026-07-30 | 2026-10-13 |
| Autus Valve Continued Access Study (CAS) Pulmonary Valve Replacement Surgery - Congenital Heart Disease | Not applicable | Active not recruiting | Edwards Lifesciences | 4 | 2026-07-27 | 2026-10-20 |
| Interoceptive Intervention for Congenital Heart Disease Interoceptive-Based Group Intervention - Interoception, Congenital Heart Disease | Not applicable | Not yet recruiting | University of Glasgow | 32 | 2026-07-01 | 2026-07-13 |
| Exergame-Based Physical Activity Promotion for Children and Adolescents With Congenital Heart Disease Nintendo Switch-Based Exergame Physical Activity Promotion Intervention - Congenital Heart Disease, Physical Inactivity | Not applicable | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 13 | 2026-07-01 | 2026-05-18 |
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Heart Defects, Congenital (538) · Heart Failure (29) · Univentricular Heart (24) · Tetralogy of Fallot (19) · Motor Activity (15) · Arrhythmias, Cardiac (14) · Cardiovascular Diseases (13) · Acute Kidney Injury (12) · Heart Valve Diseases (12) · Hypoplastic Left Heart Syndrome (11) · Hypertension, Pulmonary (10) · Heart Diseases (9) · Transposition of Great Vessels (9) · Pulmonary Arterial Hypertension (8) · Death, Sudden, Cardiac (7)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (538) · Cardiovascular Abnormalities (537) · Congenital Abnormalities (534) · Heart Diseases (529) · Cardiovascular Diseases (525) · Pathological Conditions, Signs and Symptoms (75) · Pathologic Processes (58) · Vascular Diseases (38) · Respiratory Tract Diseases (35) · Female Urogenital Diseases and Pregnancy Complications (32) · Urogenital Diseases (32) · Behavior (31) · Lung Diseases (30) · Signs and Symptoms (23) · Nutritional and Metabolic Diseases (21)
Saline Solution (11) · Blood Specimen Collection (7) · Standard of Care (7) · Dexmedetomidine (5) · Exercise (5) · Exercise Test (5) · Acetaminophen (4) · Bosentan (4) · Magnetic Resonance Spectroscopy (4) · Echocardiography (3) · Fibrinogen (3) · Nitric Oxide (3) · Restraint, Physical (3) · Sevoflurane (3) · Sildenafil Citrate (3)
Boston Children's Hospital (26) · Assiut University (15) · Emory University (15) · University Hospital, Montpellier (12) · The Hospital for Sick Children (11) · University of Alberta (10) · Children's Hospital of Fudan University (9) · Mayo Clinic (9) · Stanford University (9) · University of Michigan (7) · National Heart, Lung, and Blood Institute (NHLBI) (6) · Centre Chirurgical Marie Lannelongue (5) · Hacettepe University (5) · Medical College of Wisconsin (5) · Oslo University Hospital (5)
United States (209) · Canada (46) · China (40) · France (36) · Germany (21) · United Kingdom (18) · Italy (16) · Netherlands (16) · Turkey (Türkiye) (16) · Belgium (15) · Brazil (14) · Egypt (13) · South Korea (9) · Spain (9) · Switzerland (9)
Alexander Egbe, MBBS, MPH (3) · Alain Fraisse, MD, PhD (2) · Arlene Sirajuddin, M.D. (2) · Christoph Male, Prof,MD,PhD (2) · Daniel Tobler, MD (2) · David Faraoni, MD (2) · David P Bichell, MD (2) · Eric M Graham, MD (2) · Fernanda Lucchese-Lobato, PHD (2) · Fred Wu, MD (2) · Hee Young Kim (2) · Ida Jovanovic, Prof,MD,PhD (2) · Jamil A Aboulhosn, MD (2)
PMID 12084585, PMID 27444506, PMID 31487545, PMID 31722151, PMID 33112424, PMID 33826508, PMID 36713022, PMID 36858690, PMID 37435053, PMID 38768982, PMID 40665900, PMID 10362409, PMID 10412550, PMID 10468251, PMID 11060529, PMID 11061778, PMID 11179075, PMID 11388523, PMID 11508184, PMID 11564403, PMID 11568065, PMID 11723015, PMID 11825729, PMID 12151929, PMID 12186831, PMID 12745804, PMID 12797890, PMID 12842527, PMID 12845333, PMID 14528474, PMID 15019898, PMID 15337224, PMID 15619417, PMID 15857534, PMID 15858098, PMID 16025100, PMID 16061117, PMID 16078076, PMID 16169346, PMID 16322156, PMID 16807954, PMID 16844920, PMID 16874152, PMID 17352393, PMID 17374854, PMID 17556383, PMID 17572925, PMID 17612674, PMID 17875082, PMID 18562745
2015 (3), R01HL160761 (3), 2023 (2), 2016 (1), 2017 (1), 2018 (1), 5KL2TR001859-04 (1), K23HL093024 (1), K23HL141448 (1), K23HL151801 (1), K23HL151866 (1), K23HL165083 (1), K23HL166771 (1), R01CA204585 (1), R01HL077485 (1)