112 unknown. 112 Phase 2, 21 Phase 1, 21 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 112 | Unknown 112 |
| Phase 1 | 21 | Unknown 21 |
| Phase 3 | 21 | Unknown 21 |
Follow Congenital Abnormalities: new trials by email Literature Review of Congenital Abnormalities trials Research Report on Congenital Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vosoritide for Short Stature in Turner Syndrome Vosoritide - Turner Syndrome, Short Stature | Phase 2 | Unknown | Roopa Kanakatti Shankar, MBBS, MS | 20 | 2024-04-12 | 2024-06-24 |
| CVL237 Tablets for APDS/PASLI CVL237 tablets, CVL237 placebo tablets - PI3K and P110delta Hyperactivation Syndrome | Phase 2 / Phase 3 | Unknown | Convalife (Shanghai) Co., Ltd. | 35 | 2024-03-30 | 2024-03-05 |
| Preventive Effect of Perinatal Oral Probiotic Supplementation (POPS) on Neonatal Jaundice Vivomixx®, Placebo - Neonatal Jaundice, Microtia | Phase 2 | Unknown | Chinese University of Hong Kong | 94 | 2024-03-23 | 2024-05-20 |
| Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates Paracetamol - Patent Ductus Arteriosus | Phase 1 / Phase 2 | Unknown | Soha mahmoud Hussien mahdy | 100 | 2024-03-01 | 2024-02-13 |
| Tirzepatide Monotherapy in Patients With Wolfram Syndrome Type 1 Tirzepatide - Wolfram Syndrome | Phase 2 | Unknown | Ospedale San Raffaele | 10 | 2024-01-01 | 2024-02-22 |
| Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus Paracetamol, Ibuprofen - Patent Ductus Arteriosus | Phase 2 | Unknown | Assiut University | 56 | 2023-12-01 | 2023-12-01 |
| Treat Autosomal Dominant Polycystic Kidney Disease With Oral Ketone Ester? Ketone ester - ADPKD | Phase 2 | Unknown | Universitair Ziekenhuis Brussel | 20 | 2023-11-01 | 2023-10-25 |
| Part II: Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia Filgrastim - Biliary Atresia | Phase 2 | Unknown | Holterman, Ai-Xuan, M.D. | 400 | 2023-09-01 | 2023-09-08 |
| Hereditary Sensory Neuropathy Serine Trial L-serine, Placebo - Hereditary Sensory Neuropathy Type I | Phase 2 | Unknown | University College, London | 50 | 2023-08-21 | 2023-11-02 |
| Evaluation of Antimicrobial Photodynamic Therapy and Minimal Intervention Associated With Deproteinization in Permanent Teeth With Molar Incisor Hypomineralization Antimicrobial PDT and Papacarie Deproteinization, Conventional caries treatment, Antimicrobial PDT and 5% NaOCl Deproteinization - Hypomineralization Molar Incisor | Phase 1 / Phase 2 | Unknown | University of Nove de Julho | 69 | 2023-08-20 | 2023-11-28 |
| Pazopanib for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia Pazopanib - Hereditary Hemorrhagic Telangiectasia, Epistaxis | Phase 1 / Phase 2 | Unknown | Cure HHT | 30 | 2023-07-01 | 2022-09-08 |
| Study to Evaluate Safety and Efficacy of ALLO-ASC-SHEET in Subjects With Dystrophic Epidermolysis Bullosa ALLO-ASC-SHEET, Vehicle Control - Dystrophic Epidermolysis Bullosa | Phase 2 | Unknown | Anterogen Co., Ltd. | 6 | 2023-05-01 | 2024-04-22 |
| 68Ga-NY104 PET/CT in Von Hippel-Lindau Disease 68Ga-NY104 PET/CT Contrast-enhanced MRI of the brain and contrast-enhanced CT of abdomen and pelvis) 68Ga-NODAGA-LM3 PET/CT (exploratory) - Von Hippel-Lindau Disease | Phase 2 | Unknown | Peking Union Medical College Hospital | 19 | 2023-05-01 | 2023-05-11 |
| Study of PTW-002 in Patients With Dominant or Recessive Dystrophic Epidermolysis Bullosa Due to Mutation(s) in Exon 73 of the COL7A1 Gene PTW-002 10 mg/g gel, Placebo - Dystrophic Epidermolysis Bullosa | Phase 1 / Phase 2 | Unknown | Phoenicis Therapeutics | 8 | 2023-04-30 | 2023-03-31 |
| Research of SORD-CMT Natural History and Epalrestat Treatment Epalrestat - Charcot-Marie-Tooth Disease (CMT) | Phase 2 | Unknown | The Third Xiangya Hospital of Central South University | 30 | 2023-04-01 | 2023-04-18 |
| A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Glycerin 0.2%/Hypromellose 0.2%/Peg 1%/Soln,Oph,Ud - Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy | Phase 2 / Phase 3 | Unknown | Wills Eye | 80 | 2023-02-06 | 2024-07-30 |
| " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " Sacubitril 49 MG / Valsartan 51 MG [Entresto] BID, Empagliflozin 10 MG OD - Congenital Heart Disease, Heart Failure | Phase 2 / Phase 3 | Unknown | Instituto Nacional de Cardiologia Ignacio Chavez | 160 | 2023-02-06 | 2022-11-02 |
| BR790 in Combination With Anlotinib in Adult Subjects With Advanced Non-Small Cell Lung Cancer BR790+anlotinib - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Unknown | Shanghai Gopherwood Biotech Co., Ltd. | 90 | 2023-02-01 | 2023-02-10 |
| Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome Bumetanide, Placebo - Down Syndrome | Phase 2 | Unknown | Stefano Vicari | 64 | 2023-01-11 | 2024-06-20 |
| Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin - Retrognathism, Prognathism | Phase 2 / Phase 3 | Unknown | Universitat Internacional de Catalunya | 220 | 2022-09-30 | 2022-09-13 |
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Heart Defects, Congenital (12) · Ductus Arteriosus, Patent (8) · Leukemia (6) · Leukemia, Myeloid, Acute (6) · Epidermolysis Bullosa Dystrophica (5) · Hereditary Sensory and Autonomic Neuropathies (4) · Tuberous Sclerosis (4) · Burkitt Lymphoma (3) · Epidermolysis Bullosa Simplex (3) · Foramen Ovale, Patent (3) · Heart Failure (3) · Hernias, Diaphragmatic, Congenital (3) · Hodgkin Disease (3) · Leukemia, Erythroblastic, Acute (3)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (112) · Cardiovascular Diseases (47) · Genetic Diseases, Inborn (46) · Cardiovascular Abnormalities (40) · Heart Diseases (34) · Pathological Conditions, Signs and Symptoms (31) · Nervous System Diseases (29) · Heart Defects, Congenital (22) · Abnormalities, Multiple (17) · Neoplasms (16) · Skin and Connective Tissue Diseases (16) · Female Urogenital Diseases (15) · Female Urogenital Diseases and Pregnancy Complications (15) · Male Urogenital Diseases (15)
Acetaminophen (5) · Dexmedetomidine (3) · Ibuprofen (3) · Antilymphocyte Serum (2) · Cyclosporine (2) · Cytarabine (2) · Everolimus (2) · Gentamicins (2) · Losartan (2) · Melatonin (2) · Metformin (2) · Mycophenolic Acid (2) · Propranolol (2) · Saline Solution (2) · Sirolimus (2)
Shaare Zedek Medical Center (4) · Massachusetts General Hospital (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Assiut University (2) · Cardiff University (2) · Clinuvel Europe Limited (2) · Ethicare GmbH (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Herbert Irving Comprehensive Cancer Center (2) · NMT Medical (2) · Peking Union Medical College Hospital (2) · Radboud University Medical Center (2) · Seoul National University Hospital (2) · Tel-Aviv Sourasky Medical Center (2) · University of Nove de Julho (2)
United States (23) · China (12) · Netherlands (12) · United Kingdom (10) · Italy (7) · Israel (6) · Belgium (5) · France (5) · Brazil (4) · Egypt (4) · Canada (3) · Germany (3) · Mexico (3) · Spain (3) · Austria (2)
Cathy Hammerman, MD (4) · Christoph Male, Prof,MD,PhD (2) · David G. Savage, MD (2) · Ida Jovanovic, Prof,MD,PhD (2) · Mark Reisman, MD (2) · Michael Burch, Prof,MD,PhD (2) · Michiel Dalinghaus, MD,PhD (2) · A Shash (1) · Abd-Elmoneim Shawky Shams El-deen, MD (1) · Abdel-Wahab El-Okby, MD (1) · Ahmed Said Sayed Bayomy, MSc (1) · Andrei Hancharou, Dr (1) · Angelo E Schenone, MD (1)
PMID 15107815, PMID 15701582, PMID 16219273, PMID 16322159, PMID 17307530, PMID 18254095, PMID 19128748, PMID 19217726, PMID 21051670, PMID 21525172, PMID 22065264, PMID 22170862, PMID 22417252, PMID 23234752, PMID 23321647, PMID 23341491, PMID 23543702, PMID 23771484, PMID 23796341, PMID 24753708, PMID 24815768, PMID 24824357, PMID 25046256, PMID 25147037, PMID 25346899, PMID 25835756, PMID 26283668, PMID 26811524, PMID 26824595, PMID 26951240, PMID 27733495, PMID 29138199, PMID 29222139, PMID 30520545, PMID 31211145, PMID 31217257, PMID 31574025, PMID 32034419, PMID 32865377, PMID 33186500, PMID 33447845, PMID 33497524, PMID 33692185, PMID 33832352, PMID 34629400, PMID 35234826, PMID 35391541, PMID 36038003, PMID 38101830, PMID 38709228
2015 (2), U54HD028138 (1)