1633 completed, 540 recruiting, 539 terminated, 405 unknown. 1597 Phase 2, 1491 Phase 1, 348 Phase 3, 277 Not applicable, 55 Early Phase 1.
Follow Leukemia, Myeloid, Acute: new trials by email Literature Review of Leukemia, Myeloid, Acute trials Research Report on Leukemia, Myeloid, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pyronaridine in Acute Myeloid Leukemia (AML) Pyronaridine Tetraphosphate - Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL) | Phase 2 | Suspended | Armaceutica, Inc. | 200 | 2028-02-21 | 2026-10-19 |
| Genetic Ablation of CD33 in HSC to Broaden the Therapeutic Index of CD33-directed Immunotherapy in Patients with AML Donor-derived CD34+ HSC with CRISPR/Cas9-mediated CD33 deletion, Gemtuzumab Ozogamicin - Relapsed/Refractory Acute Myeloid Leukemia (AML) | Phase 1 | Not yet recruiting | German Cancer Research Center | 12 | 2028-01-01 | 2025-03-14 |
| A Phase 1 Open-Label, Dose-Ranging Safety and Pharmacokinetics Study of Oral Cladribine in Patients With Acute Myeloid Leukemia (AML) Cytarabine, Oral Cladribine - Acute Myeloid Leukemia (AML) | Phase 1 / Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 58 | 2027-12-01 | 2026-08-25 |
| Universal CAR-T Cells Targeting AML CLL-1, CD33, CD38 and/or CD123-specific universal CAR- T cells - Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-08-27 |
| Universal 4SCAR7U Targeting CD7-positive Malignancies Universal CD7-specific CAR gene-engineered T cells - T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-08-26 |
| A Clinical Study to Investigate the Safety and Efficacy of Off-the-Shelf iNKT Cell Injection Targeting CD33/CD70 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia GT737 Injection - Relapsed/Refractory Acute Myeloid Leukemia (AML) | Early Phase 1 | Not yet recruiting | Grit Biotechnology | 36 | 2027-05-01 | 2026-09-11 |
| Axatilimab Combined With Decitabine/Venetoclax for the Treatment of TP53-mutated AML Decitabine, Venetoclax, Axatilimab - Acute Myeloid Leukemia, TP53 Gene Mutation | Phase 1 | Not yet recruiting | Northside Hospital, Inc. | 32 | 2027-01-31 | 2026-10-16 |
| Testing the Investigational Medication Combination of Azacitidine, Venetoclax, and Quizartinib Compared to the Usual Treatment of Cytarabine, Daunorubicin, and Quizartinib for Patients With FLT3-ITD Mutant Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) Azacitidine, Biospecimen Collection, Bone Marrow Aspiration - Acute Myeloid Leukemia | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 122 | 2027-01-15 | 2026-10-07 |
| Venetoclax or Placebo in Combination With Reduced-Intensity Conditioning Hematopoietic Cell (Bone Marrow/Blood Stem Cell) Transplant and as Maintenance Therapy After Transplant in Patients With Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) Allogeneic Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Biopsy - Acute Myeloid Leukemia | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 244 | 2027-01-15 | 2026-10-20 |
| Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia Following Initial Treatment, The ERASE Study (A MyeloMATCH Treatment Trial) Azacitidine, Bone Marrow Aspiration and Biopsy, Cytarabine - Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 184 | 2027-01-04 | 2026-10-01 |
| CD34+ Transplants for Myeloid Malignancies Busulfan, Melphalan, Fludarabine - Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute | Phase 2 | Not yet recruiting | Guenther Koehne | 50 | 2027-01-01 | 2026-10-13 |
| Feasibility and Efficiency Study for the Implementation of a New Screening Method for Patients With Acute Myeloid Leukemia, in Laboratory Practice Bone marrow or peripheral blood withdrawal for test comparison - Acute Myeloid Leukemia, Acute Myeloid Leukemia, Adult | Not applicable | Not yet recruiting | Gruppo Italiano Malattie EMatologiche dell'Adulto | 75 | 2027-01-01 | 2026-10-09 |
| Study of Monzosertib In Patients With R/R AML Or High-Risk Myelodysplastic Syndrome Monzosertib, Posaconazole, Isavuconazole - Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome | Phase 1 | Not yet recruiting | M.D. Anderson Cancer Center | 42 | 2027-01-01 | 2026-08-21 |
| GRACE: A Phase 1/2a Study of VTRU200 in Relapsed/Refractory AML, High-risk MDS, DLBCL Post CART Failure and Advanced Solid Tumors VTRU200 - Acute Myeloid Leukemia, Diffuse Large B Cell Lymphoma (DLBCL) | Phase 1 / Phase 2 | Not yet recruiting | Vitruviae | 108 | 2027-01-01 | 2026-08-06 |
| Improving Delivery of Aging-Related Supportive Care for Older Adults With Acute Myeloid Leukemia Active Default - Acute Myeloid Leukemia (AML) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 40 | 2027-01-01 | 2026-10-13 |
| Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration - Acute Biphenotypic Leukemia, Acute Leukemia | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 52 | 2027-01-01 | 2026-09-14 |
| Prevention of Oral Mucositis in Adults in With Hematologic Malignancy Aloe Vera Mouthwash, Standard of Care - Acute Leukemia, Acute Myeloid Leukemia | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 206 | 2027-01-01 | 2026-10-22 |
| Multi-CAR T Cell Therapy for Acute Myeloid Leukemia Muc1/CLL1/CD33/CD38/CD56/CD123-specific gene-engineered T cells - Acute Myeloid Leukemia | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-08-26 |
| A Study of Cladribine, Low Dose Cytarabine, and Venetoclax in Treatment of Relapsed/Refractory or Secondary Acute Myeloid Leukemia CAV - Acute Myeloid Leukemia (AML) | Phase 2 | Not yet recruiting | University of Rochester | 24 | 2026-12-31 | 2026-10-16 |
| Multi-CAR T Cell Therapy Targeting CD7-positive Malignancies CD7-specific CAR gene-engineered T cells - T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2026-12-31 | 2026-08-26 |
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Myelodysplastic Syndromes (1058) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (863) · Leukemia (776) · Lymphoma, Non-Hodgkin (428) · Leukemia, Lymphocytic, Chronic, B-Cell (415) · Congenital Abnormalities (375) · Leukemia, Myelomonocytic, Chronic (363) · Multiple Myeloma (358) · Hodgkin Disease (356) · Recurrence (325) · Myeloproliferative Disorders (312) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (299) · Lymphoma (280) · Blast Crisis (269)
Hemic and Lymphatic Diseases (3699) · Neoplasms by Histologic Type (3690) · Hematologic Diseases (3660) · Leukemia, Myeloid (3633) · Neoplasms (3553) · Leukemia (2923) · Bone Marrow Diseases (1501) · Pathological Conditions, Signs and Symptoms (1128) · Pathologic Processes (1115) · Immune System Diseases (1084) · Disease Attributes (1050) · Immunoproliferative Disorders (1048) · Lymphatic Diseases (1034) · Lymphoproliferative Disorders (1021) · Leukemia, Lymphoid (943)
Cytarabine (582) · Azacitidine (408) · venetoclax (331) · Cyclophosphamide (296) · fludarabine (253) · fludarabine phosphate (233) · Decitabine (190) · Busulfan (184) · Daunorubicin (166) · Idarubicin (162) · Peripheral Blood Stem Cell Transplantation (140) · Filgrastim (137) · Mycophenolic Acid (137) · Whole-Body Irradiation (136) · Tacrolimus (128)
M.D. Anderson Cancer Center (195) · National Cancer Institute (NCI) (155) · Fred Hutchinson Cancer Center (112) · City of Hope Medical Center (62) · Masonic Cancer Center, University of Minnesota (57) · Memorial Sloan Kettering Cancer Center (53) · The First Affiliated Hospital of Soochow University (53) · Institute of Hematology & Blood Diseases Hospital, China (44) · Novartis Pharmaceuticals (42) · AbbVie (41) · Washington University School of Medicine (41) · Children's Oncology Group (35) · St. Jude Children's Research Hospital (34) · Wake Forest University Health Sciences (32) · Massachusetts General Hospital (31)
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Brenda Sandmaier (15) · Jorge Cortes, MD (15) · Farhad Ravandi-Kashani, MD (13) · Courtney DiNardo, MD (10) · Guillermo Garcia-Manero, MD (9)
PMID 32499241, PMID 33394722, PMID 24383844, PMID 25527568, PMID 36064577, PMID 36184192, PMID 23524640, PMID 42013378, PMID 23065508, PMID 22965967, PMID 24923295, PMID 30062662, PMID 31171508, PMID 31375516, PMID 35829925, PMID 37267439, PMID 20705755, PMID 23841729, PMID 27400939, PMID 29702001, PMID 29859851, PMID 32786187, PMID 35007144, PMID 35790816, PMID 37093350, PMID 37341189, PMID 38429079, PMID 38507688, PMID 39133921, PMID 39368878, PMID 40073835, PMID 18824593, PMID 18997171, PMID 19602710, PMID 20625116, PMID 20644121, PMID 21343560, PMID 21385856, PMID 21459791, PMID 21459795, PMID 21527516, PMID 21715313, PMID 22133778, PMID 22158386, PMID 22627678, PMID 22649106, PMID 22715121, PMID 23071272, PMID 23248249, PMID 23660685
P30CA015704 (55), P30CA033572 (46), 2018 (24), P30CA006973 (24), P30CA016672 (22), P01CA018029 (21), U10CA032102 (21), 2023 (20), U01CA070095 (20), P30CA043703 (19), 2015 (17), 2016 (17), 2025 (17), U10CA031946 (17), 2017 (16)