2 completed, 2 terminated, 1 not yet recruiting, 1 recruiting. 7 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 2, Terminated 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 3 | 2 | Not yet recruiting 1, Unknown 1 |
Follow Concussion: new trials by email Literature Review of Concussion trials Research Report on Concussion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| BCAAs in Concussion 3.0 BCAA, Placebo - Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury | Phase 2 | Recruiting | Akiva Cohen | 150 | 2026-08-05 | 2026-09-03 |
| BCAAs in Concussion 2.0 BCAA, Placebo - Concussion, Brain, Concussion, Mild | Phase 2 | Completed | Akiva Cohen | 17 | 2025-04-01 | 2026-09-03 |
| Sphenopalatine Ganglion Block for Headache After Concussion Lidocaine in SphenoCath device, Saline Solution in SphenoCath device - Concussion, Headache | Phase 2 | Terminated | University of Michigan | 2 | 2021-03-18 | 2022-09-14 |
| A Safety and Efficacy Study of NNZ-2566 in Patients With Mild Traumatic Brain Injury (mTBI) NNZ-2566, Placebo - Concussion | Phase 2 | Terminated | Neuren Pharmaceuticals Limited | 32 | 2014-09-01 | 2018-02-05 |
| PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin Melatonin, Sugar pill - Post-concussion Syndrome, Post-concussive Symptoms | Phase 2 / Phase 3 | Unknown | University of Calgary | 99 | 2013-09-01 | 2017-04-18 |
| Interactive Training in Sports Concussion Prevention and Management Brain 101 website, Control - Concussion | Phase 2 | Completed | Oregon Center for Applied Science, Inc. | 25 | 2011-08-01 | 2013-11-08 |
Brain Concussion (7) · Brain Injuries, Traumatic (1) · Depression (1) · Disease (1) · Headache (1) · Post-Concussion Syndrome (1)
Brain Diseases (7) · Brain Injuries (7) · Central Nervous System Diseases (7) · Craniocerebral Trauma (7) · Head Injuries, Closed (7) · Nervous System Diseases (7) · Trauma, Nervous System (7) · Wounds and Injuries (7) · Wounds, Nonpenetrating (7) · Brain Injuries, Traumatic (6) · Pathological Conditions, Signs and Symptoms (2) · Behavior (1) · Behavioral Symptoms (1) · Neurologic Manifestations (1) · Pain (1)
Lidocaine (1) · Melatonin (1) · Saline Solution (1) · Sugars (1) · trofinetide (1)
Akiva Cohen (2) · Neuren Pharmaceuticals Limited (1) · Oregon Center for Applied Science, Inc. (1) · University of Calgary (1) · University of Florida (1) · University of Michigan (1)
United States (6) · Canada (1)
Daniel Corwin, MD (2) · Alex Hishaw, MD (1) · Ann E Glang, PhD (1) · Brian O'Neil, MD (1) · Karen M Barlow, MB.ChB (1) · Kurt Denninghoff, MD (1) · Michael Popovich, MD (1) · Sara Gould, MD (1) · Wesley R Cole, Ph.D (1)
PMID 25438964, PMID 32217739, PMID 32772826, PMID 38468511
R44HD056610 (1)