10 completed, 3 recruiting, 1 terminated. 4 Phase 1, 4 Phase 2, 3 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 4 | Completed 4 |
| Not applicable | 3 | Completed 1, Recruiting 1, Terminated 1 |
Follow CNS Cancer: new trials by email Literature Review of CNS Cancer trials Research Report on CNS Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe Brain Cancer, Brain Cancer Metastatic | Recruiting | University of California, Irvine | 12 | 2026-08-04 | 2026-09-18 | |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors Pencil Beam Scanning Proton Therapy - CNS Cancer, Head and Neck Cancer | Not applicable | Recruiting | The New York Proton Center | 1800 | 2022-01-24 | 2026-04-13 |
| Avera Cancer Sequencing and Analytics Protocol (ASAP) Cancer, Cancer Diagnosis | Recruiting | Avera McKennan Hospital & University Health Center | 25000 | 2021-11-01 | 2026-10-28 | |
| The Registry of Oncology Outcomes Associated With Testing and Treatment Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P) - Adenocarcinoma, Adenocystic Carcinoma | Completed | Taproot Health | 167 | 2021-05-05 | 2024-12-18 | |
| Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors Prexasertib, Cyclophosphamide, Gemcitabine - Brain Tumor, Brain Tumor, Recurrent | Phase 1 | Completed | St. Jude Children's Research Hospital | 21 | 2019-08-08 | 2025-02-07 |
| Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Sunitinib - CNS Cancer, Meningioma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 50 | 2007-10-01 | 2016-01-25 |
| Language Function in Patients With Brain Tumors fMRI Scan, pre- and post language evaluation - Brain Cancer, CNS Cancer | Completed | Memorial Sloan Kettering Cancer Center | 7 | 2005-05-01 | 2009-07-08 | |
| Adjunctive Donepezil Therapy and Genetic Risk Factors of Cognitive Dysfunction in Brain Tumor Survivors donepezil and questionaires - Brain Tumor, Brain Cancer | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 25 | 2004-10-01 | 2016-01-14 |
| Study of D-Methadone in Patients With Chronic Pain d-Methadone, D-methadone, placebo - Pain, Bladder Cancer | Phase 1 / Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 10 | 2004-10-01 | 2016-08-10 |
| Imaging Brain Tumors With FACBC and Methionine FACBC, Methionine, PET Scan - Brain Cancer, CNS Cancer | Not applicable | Completed | Memorial Sloan Kettering Cancer Center | 30 | 2003-05-13 | 2020-12-17 |
| Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma temozolomide followed by high dose busulfan and thiotepa - CNS Cancer, CNS BRAIN | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 60 | 2002-09-01 | 2023-10-27 |
| Tumor Detection Using Iodine-131-Labeled Monoclonal Antibody 8H9 131I-8H9, 8H9 - CNS Cancer, Neuroblastoma | Not applicable | Terminated | Memorial Sloan Kettering Cancer Center | 12 | 2001-10-01 | 2017-03-01 |
| Spectroscopy With Surface Coils and Decoupling Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T - Adrenal Cortical Cancer, Brain Cancer | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 582 | 1997-02-01 | 2015-12-28 |
Central Nervous System Neoplasms (14) · Brain Neoplasms (9) · Breast Neoplasms (5) · Colonic Neoplasms (4) · Neoplasms (4) · Prostatic Neoplasms (4) · Head and Neck Neoplasms (3) · Lung Neoplasms (3) · Ovarian Neoplasms (3) · Pancreatic Neoplasms (3) · Sarcoma (3) · Esophageal Neoplasms (2) · Gastrointestinal Neoplasms (2) · Kidney Neoplasms (2) · Liver Neoplasms (2)
Neoplasms by Site (14) · Nervous System Diseases (14) · Nervous System Neoplasms (13) · Neoplasms (10) · Brain Diseases (9) · Central Nervous System Diseases (9) · Neoplasms by Histologic Type (6) · Breast Diseases (5) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Genital Diseases (5) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Glandular and Epithelial (5) · Neoplasms, Nerve Tissue (5)
Biological Therapy (1) · Busulfan (1) · Cyclophosphamide (1) · D-methadone (1) · Donepezil (1) · Drug Therapy (1) · Filgrastim (1) · Gemcitabine (1) · Granulocyte Colony-Stimulating Factor (1) · Immunotherapy (1) · Lead (1) · Magnetic Resonance Spectroscopy (1) · Methionine (1) · Mn-PyC3A (1) · Molecular Diagnostic Techniques (1)
Memorial Sloan Kettering Cancer Center (8) · Avera McKennan Hospital & University Health Center (1) · Reveal Pharmaceuticals Inc. (1) · St. Jude Children's Research Hospital (1) · Taproot Health (1) · The New York Proton Center (1) · University of California, Irvine (1)
United States (14)
Thomas Kaley, MD (2) · Aaron Simon, MD (1) · Andrei Holodny, MD (1) · Denise Correa, PhD (1) · Giles W. Robinson, MD (1) · Jason Koutcher, MD, PhD (1) · Jennifer Johnson, MD, PhD (1) · Natalie Moryl, MD (1) · Rachel Elsey, PharmD (1) · Raymond Bergan, MD (1) · Razelle Kurzrock, MD (1) · Shakeel Modak, MD (1) · Vivek Subbiah, MD (1)
R44CA261240 (1)