4 completed, 1 suspended. 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Completed 2, Suspended 1 |
Follow this drug Literature Review of D-methadone trials Research Report on D-methadone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo D-methadone, Placebo - Restless Legs Syndrome | Phase 2 | Suspended | Mauro Manconi | 50 | 2022-10-22 | 2026-03-13 |
| Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD REL-1017, Placebo - Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant | Phase 2 | Completed | Relmada Therapeutics, Inc. | 62 | 2018-05-11 | 2023-11-01 |
| Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone) REL-1017, Placebo - Neuropathic Pain | Phase 1 | Completed | Relmada Therapeutics, Inc. | 24 | 2015-08-31 | 2018-08-20 |
| Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone) REL-1017, Placebo - Neuropathic Pain | Phase 1 | Completed | Relmada Therapeutics, Inc. | 42 | 2014-12-04 | 2019-08-01 |
| Study of D-Methadone in Patients With Chronic Pain d-Methadone, D-methadone, placebo - Pain, Bladder Cancer | Phase 1 / Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 10 | 2004-10-01 | 2016-08-10 |
Neuralgia (2) · Breast Neoplasms (1) · Central Nervous System Neoplasms (1) · Colonic Neoplasms (1) · Depression (1) · Depressive Disorder, Major (1) · Depressive Disorder, Treatment-Resistant (1) · Esophageal Neoplasms (1) · Eye Neoplasms (1) · Head and Neck Neoplasms (1) · Otorhinolaryngologic Neoplasms (1) · Pain (1) · Pancreatic Neoplasms (1) · Prostatic Neoplasms (1) · Restless Legs Syndrome (1)
Relmada Therapeutics, Inc. (3) · Mauro Manconi (1) · Memorial Sloan Kettering Cancer Center (1)
United States (2) · Italy (1) · Switzerland (1)
Maurizio Fava, MD (1) · Mauro Manconi, Prof. MD (1) · Natalie Moryl, MD (1)