17 completed, 1 active not recruiting, 1 available, 1 not yet recruiting. 10 Not applicable, 7 Phase 2, 6 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 8, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 7 | Completed 5, Active not recruiting 1, Terminated 1 |
| Phase 3 | 6 | Completed 5, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
Follow Methionine: new trials by email Literature Review of Methionine trials Research Report on Methionine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methionine for CaPhos Stone L-Methionine - Calcium Phosphate Kidney Stones | Not applicable | Not yet recruiting | Ryan L Steinberg | 15 | 2026-04-01 | 2026-03-11 |
| Comparative Study of REMAXA®, Enteric-coated Tablets and REMAXOL®, Solution for Infusions, in Intrahepatic Cholestasis Remaxa, enteric-coated tablets, Remaxol, Placebo - Cholestasis, Intrahepatic | Phase 2 / Phase 3 | Completed | POLYSAN Scientific & Technological Pharmaceutical Company | 328 | 2023-05-27 | 2025-04-29 |
| Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. Methionine, Vitamin B12, B9, B6, C supplementation, Methionine/homocysteine Dosage - Pulmonary Alveolar Proteinosis, Mutation Ala393Thr of the MARS Gene | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 3 | 2019-09-16 | 2025-11-20 |
| Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity Cellulose (control), Glycine, Alanine - Atherosclerosis, Diet Modification | Not applicable | Unknown | Rambam Health Care Campus | 110 | 2017-07-01 | 2017-06-08 |
| Remaxol® in Mechanical Jaundice of Non-malignant Origin Remaxol (succinate + methionine + inosine + nicotinamide), Ringer's Solution - Jaundice, Obstructive | Phase 3 | Completed | POLYSAN Scientific & Technological Pharmaceutical Company | 342 | 2017-04-03 | 2020-07-14 |
| Remaxol® in Malignant Mechanical Jaundice Remaxol®, Ringer's Solution - Jaundice; Malignant | Phase 3 | Completed | POLYSAN Scientific & Technological Pharmaceutical Company | 240 | 2017-04-03 | 2020-07-10 |
| Multiparametric Imaging in Multiple Myeloma C11 Methionine positron emission tomography - Multiple Myeloma | Phase 1 | Completed | Yingbing Wang | 10 | 2016-07-01 | 2021-09-16 |
| Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis Methionine, DOTANOC - Pulmonary Sarcoidosis | Phase 2 / Phase 3 | Terminated | Turku University Hospital | 5 | 2016-05-01 | 2026-10-07 |
| Methionine Tolerance in Healthy Human Adults methionine - Healthy | Not applicable | Completed | Texas A&M University | 15 | 2015-07-01 | 2018-09-26 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract to Prevent Postoperative Urinary Tract Infection. L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract, Placebo - Urinary Tract Infection, Pelvic Organ Prolapse | Not applicable | Completed | IRCCS San Raffaele | 150 | 2014-10-01 | 2015-08-26 |
| Vitamin B6 Effects for Women Taking Birth Control Pills Vitamin B6, Infusion of labeled serine, methionine and leucine - Vitamin B6 Deficiency | Phase 2 / Phase 3 | Completed | University of Florida | 13 | 2010-04-01 | 2017-02-07 |
| Estrogen and Serotonin on Changing Brain Chemistry estrogen patch, Amino acids, Placebo Patch - Menopause | Not applicable | Completed | University of Colorado, Denver | 47 | 2010-03-04 | 2021-04-02 |
| Methionine PET/CT Studies In Patients With Cancer Methionine - Brain Tumors and/or Solid Tumors Including, Brain Stem Glioma | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 503 | 2009-07-20 | 2026-06-17 |
| Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation Essential amino acids, Alanine - Osteoarthritis | Not applicable | Completed | University of Oregon | 60 | 2008-06-01 | 2014-12-04 |
| Vitamin B6 Dependence of One-Carbon Metabolism Arm 1 glycine and leucine, Arm 2 Intervention of Serine and methionine infusion - Vitamin B6 Deficiency | Not applicable | Completed | University of Florida | 45 | 2008-01-01 | 2013-03-27 |
| Methionine-Restriction Diet (MRD) in Obese Adults With Metabolic Syndrome Methionine deficient diet, Methionine sufficient diet - Metabolic Syndrome | Phase 2 | Completed | Pennington Biomedical Research Center | 56 | 2006-07-01 | 2015-12-18 |
| Metabolic Effects of Chemical Interactions in Toxicity acetominophen, sulfer amino acids; cysteine and methionine - Oxidative Stress | Not applicable | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 15 | 2005-01-01 | 2010-01-13 |
| Metabolic Analysis in Human Sulfur Amino Acid Deficiency dietary amino acids; cysteine and methionine - Oxidative Stress, Diabetes | Not applicable | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 15 | 2004-02-01 | 2010-03-18 |
| Imaging Brain Tumors With FACBC and Methionine FACBC, Methionine, PET Scan - Brain Cancer, CNS Cancer | Not applicable | Completed | Memorial Sloan Kettering Cancer Center | 30 | 2003-05-13 | 2020-12-17 |
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Central Nervous System Neoplasms (2) · Jaundice, Obstructive (2) · Vitamin B 6 Deficiency (2) · Atherosclerosis (1) · Brain Neoplasms (1) · Cholestasis, Intrahepatic (1) · Craniopharyngioma (1) · Diabetes Mellitus (1) · Disease (1) · Ependymoma (1) · Head and Neck Neoplasms (1) · Heart Diseases (1) · Hodgkin Disease (1) · Jaundice (1) · Lymphoma, Non-Hodgkin (1)
POLYSAN Scientific & Technological Pharmaceutical Company (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · St. Jude Children's Research Hospital (2) · University of Florida (2) · University of Oregon (2) · Assistance Publique - Hôpitaux de Paris (1) · IRCCS San Raffaele (1) · Memorial Sloan Kettering Cancer Center (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Pennington Biomedical Research Center (1) · Rambam Health Care Campus (1) · Ryan L Steinberg (1) · Texas A&M University (1) · Turku University Hospital (1) · University of Colorado, Denver (1)
United States (13) · Russia (3) · Finland (1) · France (1) · Italy (1)
Mikhail S. Bogomolov, MD, PhD (2) · Alessandro Di Rocco, MD (1) · Barry L Shulkin, MD (1) · Barry L. Shulkin, MD, MBA (1) · Cynthia Neill Epperson, M.D. (1) · Dean Jones, Ph.D. (1) · Dean P Jones, Ph.D. (1) · Hans C Dreyer, PT, PhD (1) · Jesse F Gregory, PhD (1) · Jesse Gregory, PhD (1) · Juhani Knuuti, MD, PhD (1) · Marielle Engelen (1) · Stefano Salvatore, MD (1)
PMID 25527663, PMID 26765812, PMID 12449285, PMID 17364057, PMID 18029478, PMID 19158217, PMID 19515736, PMID 21346062, PMID 21430249, PMID 22204954, PMID 24135139, PMID 24401239, PMID 26201817, PMID 26733251, PMID 26829246, PMID 26962179, PMID 28637772, PMID 30280129, PMID 31343947, PMID 34503986, PMID 36382911
2018 (1), K01HD057332 (1), P50MH099910 (1), R01AG046401 (1), R03DK066008 (1)