11 completed, 7 unknown, 3 not yet recruiting, 1 recruiting. 11 Not applicable, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 5, Not yet recruiting 3, Unknown 3 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Chronic Total Occlusion: new trials by email Literature Review of Chronic Total Occlusion trials Research Report on Chronic Total Occlusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Drug-Coated Balloon Only Strategy After Recanalization of Chronic Total Coronary Occlusions Paclitaxel-coated balloon (AGENT Paclitaxel-Coated PTCA Balloon Catheter), Serial intravascular ultrasound and protocol-mandated nine-month angiographic reassessment - Angina (Stable), Coronary Occlusion | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 38 | 2026-11-01 | 2026-09-14 |
| CABG Versus PCI in Patients With Isolated LAD Chronic Total Occlusion Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention - Chronic Total Occlusion | Completed | Mersin Medicalpark Hastanesi | 302 | 2025-09-10 | 2026-01-28 | |
| CTO-PCI in Heart Failure Patients CTO-PCI - Coronary Artery Disease, Chronic Total Occlusion | Not applicable | Not yet recruiting | Universitätsmedizin Mannheim | 783 | 2025-09-01 | 2024-09-19 |
| Sapphire 3 CTO Study Sapphire 3 Coronary Dilatation Catheter - Coronary Artery Disease, Coronary Disease | Not applicable | Completed | OrbusNeich | 170 | 2024-11-06 | 2026-01-12 |
| Antiplatelet Therapy After Successful Percutaneous Coronary Intervention for Chronically Occluded Coronary Artery Percutaneous coronary intervention, Short dual Aspirin/Clopidogrel therapy, Long dual Aspirin/Clopidogrel therapy - Chronic Total Occlusion | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 660 | 2024-03-30 | 2023-12-18 |
| Chronic Total Occlusive Lesions CMR Study Percutaneous coronary intervention - Chronic Total Occlusion, Image | Unknown | Lin Zhao | 400 | 2023-01-20 | 2023-08-01 | |
| Impact of CTO PCI (Chronic Total Occlusion Percutaneous Intervention) on Regular Physical Activity Chronic total occlusion percutaneous coronary intervention - Chronic Total Occlusion, Occlusion | Terminated | Minneapolis Heart Institute Foundation | 1 | 2022-09-01 | 2025-01-24 | |
| Decreasing Patient Anxiety During Revascularization of Chronic Total Coronary Occlusions Using Virtual Reality Glasses. Virtual reality headset during percutaneous coronary intervention - Chronic Total Occlusion, Anxiety | Not applicable | Unknown | Fundación para la Investigación del Hospital Clínico de Valencia | 58 | 2021-12-01 | 2022-07-14 |
| Clinical Study Evaluating Use of the CapBuster Medical Device System for the Crossing of Chronic Total Occlusions CapBuster - Chronic Total Occlusion | Not applicable | Unknown | Praxis Medical Devices Ltd | 26 | 2021-06-21 | 2023-02-21 |
| Evaluation of the Radiological Dose Delivered to Risky Interventional Cardiology Patients (Optidose) Gafchromic film - X-rays; Effects, Chronic Total Occlusion | Completed | GCS Ramsay Santé pour l'Enseignement et la Recherche | 83 | 2020-09-24 | 2026-07-16 | |
| Chronic Total Occlusion Percutaneous Coronary Intervention Study Chronic Total Occlusion Revascularization, GuideLiner® V3 catheter, TrapLiner® catheter, Turnpike® catheter - Chronic Total Occlusion, Ischemic Heart Disease | Not applicable | Completed | Vascular Solutions LLC | 150 | 2020-05-20 | 2022-09-28 |
| Investigating the Utility of Remote Index of Microvascular Resistance in Patients With Chronic Total Occlusion Directly measure microvascular function using direct coronary flow measurements - Chronic Total Occlusion | Not applicable | Completed | University of Chicago | 4 | 2020-01-15 | 2023-08-24 |
| Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO) Roxwood Anchoring Catheters, Acetylsalicylic Acid, Heparin - Chronic Total Occlusion, Atherosclerosis | Withdrawn | Boston Scientific Corporation | 2019-10-31 | 2021-07-21 | ||
| Use of Drug-Coated Balloon to Improve Recanalization of a Coronary Chronic Total Occlusion After Failed Angioplasty Paclitaxel-coated Balloon dilation angioplasty, Non-coated Balloon dilation angioplasty - Chronic Total Occlusion | Completed | Ignacio J. Amat Santos | 44 | 2018-10-01 | 2022-04-22 | |
| STENTYS Xposition S in the Treatment of Chronic Total Artery Occlusion Implantation of Stent (PCI) - Chronic Total Occlusion, Coronary Artery Disease | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 50 | 2018-06-26 | 2018-08-13 |
| German Epicardial Collateral CTO Registry Retrograde Percutaneous Coronary Intervention of Chronic Total Occlusion - Coronary Artery Disease, Chronic Total Occlusion | Unknown | Universitätsmedizin Mannheim | 500 | 2018-01-01 | 2020-09-01 | |
| A Single Center Study to Evaluate the Safety of the NovaCross Microcatheter in Crossing Chronic Total Occlusions NovaCross - Chronic Total Occlusion | Not applicable | Completed | Nitiloop Ltd. | 15 | 2017-02-01 | 2021-04-28 |
| A Prospective, Non-randomized Study to Evaluate the Safety and Performance of the NovaCross™ Microcatheter in Femoropopliteal Chronic Total Occlusion (CTO). NovaCross™ microcatheter - Chronic Total Occlusion | Not applicable | Completed | Nitiloop Ltd. | 14 | 2015-02-01 | 2016-09-21 |
| Consistent CTO Trial Percutaneous coronary intervention - Chronic Total Occlusion | Unknown | European Cardiovascular Research Center | 215 | 2014-12-01 | 2017-05-18 | |
| Coronary Interventions Ulm - Coronary Chronic Total Occlusions PCI - percutaneous coronary intervention - Chronic Total Occlusion of Coronary Artery, Chronic Total Occlusion | Unknown | University Hospital Ulm | 500 | 2014-01-01 | 2020-12-02 |
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Coronary Artery Disease (8) · Myocardial Ischemia (2) · Angina, Stable (1) · Anxiety Disorders (1) · Arteriosclerosis (1) · Atherosclerosis (1) · Bites and Stings (1) · Cardiovascular Diseases (1) · Coronary Disease (1) · Coronary Occlusion (1) · Heart Diseases (1) · Heart Failure (1) · Motor Activity (1) · Peripheral Arterial Disease (1) · Vascular Remodeling (1)
Vascular Diseases (9) · Arterial Occlusive Diseases (8) · Cardiovascular Diseases (8) · Heart Diseases (8) · Arteriosclerosis (7) · Coronary Disease (7) · Myocardial Ischemia (7) · Angina Pectoris (1) · Behavior (1) · Chemically-Induced Disorders (1) · Chest Pain (1) · Mental Disorders (1) · Neurologic Manifestations (1) · Pain (1) · Pathologic Processes (1)
Percutaneous Coronary Intervention (6) · Angioplasty (1) · Aspirin (1) · Coronary Artery Bypass (1) · Drug-Eluting Stents (1) · Heparin (1)
Boston Scientific Corporation (2) · Nitiloop Ltd. (2) · Universitätsmedizin Mannheim (2) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · BridgePoint Medical (1) · European Cardiovascular Research Center (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1) · Ignacio J. Amat Santos (1) · Lin Zhao (1) · Mersin Medicalpark Hastanesi (1) · Minneapolis Heart Institute Foundation (1) · OrbusNeich (1) · Praxis Medical Devices Ltd (1)
United States (6) · Germany (3) · Spain (3) · China (2) · France (2) · Poland (2) · Brazil (1) · Netherlands (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Andrej Schmidt (1) · Antonio D Freire, MD, PhD (1) · Chanan Schneider (1) · Chanan Schneider, Mr. (1) · David E Kandzari, MD (1) · David Kandzari, MD (1) · Dimitrios Karmpaliotis, MD, PhD (1) · Emmanouil Brilakis, MD, PhD (1) · Fenghua Ding, PhD, MD (1) · Jihad Mustapha, Dr (1) · John Blair, MD (1) · Kambis Mashayekhi, PD Dr. (1) · Lin Zhao, MD (1) · Michael Behnes, Prof. Dr. (1)