7 completed, 5 recruiting, 2 active not recruiting, 2 enrolling by invitation. 23 Phase 2, 8 Phase 1, 3 Phase 3.
Follow Children: new trials by email Literature Review of Children trials Research Report on Children
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Oral Versus Intravenous Magnesium on Emergence Delirium Magnesium glycinate, Magnesium sulfate injection, Oral juice and intravenous saline - Magnesium, Emergence Delirium | Phase 2 / Phase 3 | Recruiting | Tanta University | 360 | 2026-07-01 | 2026-07-06 |
| Romiplostim N01 for Chemotherapy-Induced Thrombocytopenia in Pediatric Cancer Patients Romiplostim N01 - Solid Tumors, Hematological Tumor | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 50 | 2025-12-25 | 2026-05-07 |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| Exploring a Natural Solution for Childhood Obesity genistein - Obesity, Children | Phase 1 / Phase 2 | Not yet recruiting | Western University | 30 | 2025-08-01 | 2025-06-24 |
| Telpegfilgrastim vs Filgrastim for Secondary Prevention of Chemotherapy-Induced Neutropenia in Pediatric Solid Tumors Telpegfilgrastim Injection, filgrastim - Solid Tumors, Children | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 132 | 2025-06-12 | 2026-05-07 |
| A Prospective, Single-arm Clinical Study of Liposomal Mitoxantrone Combination Regimen in the Treatment of Relapsed and Refractory Solid Tumors in Children, Adolescents and Young Adults Mitoxantrone liposome, Capecitabine, Anlotinib - Solid Tumors, Children | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 49 | 2025-01-24 | 2026-05-07 |
| Nivolumab and DA-EPOCH-R in Pediatric Primary Mediastinal (Thymic) Large B-cell Lymphoma Nivolumab - Primary Mediastinal (Thymic) Large B-cell Lymphoma, Children | Phase 1 / Phase 2 | Enrolling by invitation | St. Petersburg State Pavlov Medical University | 22 | 2024-09-01 | 2025-03-11 |
| Realizing Effectiveness Across Continents With Hydroxyurea Hydroxyurea - Sickle Cell Disease, Children | Phase 2 | Active not recruiting | Children's Hospital Medical Center, Cincinnati | 811 | 2023-10-27 | 2026-04-21 |
| Flexible Reinforced Laryngeal Mask Airway Versus Endotracheal Tube for Childhood Adenotonsillectomy Airway Management: Flexible Reinforced Laryngeal Mask Airway, Airway Management: Endotracheal Tube - Anesthesia Intubation Complication, Airway | Phase 2 | Completed | Maternal and Child Health Hospital of Hubei Province | 100 | 2023-08-01 | 2024-04-24 |
| Autologous Hematopoietic Stem Cell Transplantation in Pediatric Relapsed or Refractory Hodgkin Lymphoma After Nivolumab Treatment Nivolumab - Relapsed or Refractory Hodgkin Lymphoma, Children | Phase 2 | Enrolling by invitation | St. Petersburg State Pavlov Medical University | 20 | 2022-06-01 | 2025-04-17 |
| Inhaled Interferon α2b Treatment in Mild-to-moderate COVID-19 Infected Children Inhaled Interferon α2b, Standard of Care - COVID-19, Children | Phase 1 / Phase 2 | Terminated | Children's Hospital of Fudan University | 24 | 2022-01-01 | 2023-12-29 |
| A Randomized, Controlled Clinical Study on the Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Combined With Standard Immunosuppressants in the Treatment of Children With Severe Aplastic Anemia Umbilical Cord Mesenchymal Stem Cells with ATG/ALG, ATG/ALG - Sever Aplastic Aneia, Children | Phase 2 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 64 | 2021-02-25 | 2026-10-29 |
| Induction Chemotherapy in Young Patients With Locoregionally Advanced Nasopharyngeal Carcinoma Paclitaxel liposome, Cisplatin, 5-fu - Nasopharyngeal Carcinoma, Children | Phase 2 | Unknown | Sun Yat-sen University | 37 | 2016-11-14 | 2019-08-07 |
| Pilot Trial: the Safety and Feasibility of Losartan for Pulmonary Vein Stenosis Losartan - Pulmonary Vein Stenosis, Children | Phase 1 / Phase 2 | Suspended | The Hospital for Sick Children | 40 | 2016-05-01 | 2019-07-30 |
| Pharmacokinetics of Intravenous Metamizole in Children Less Than 6 Years Old Metamizole - Children, Pain | Phase 2 | Completed | University Children's Hospital Basel | 33 | 2016-04-01 | 2018-05-30 |
| Anakinra and Kawasaki Disease Anakinra - Kawasaki Disease, Children | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 16 | 2016-02-05 | 2019-07-02 |
| Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies. 0.9% saline solution, oral betamethasone placebo, adrenaline - Children, Bronchiolitis | Phase 2 / Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 195 | 2015-10-01 | 2017-09-12 |
| PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin Melatonin, Sugar pill - Post-concussion Syndrome, Post-concussive Symptoms | Phase 2 / Phase 3 | Unknown | University of Calgary | 99 | 2013-09-01 | 2017-04-18 |
| Safety and Efficacy of Fentanyl Citrate in Children midazolam and fentanyl citrate infusion, midazolam and normal saline infusion - Children | Phase 2 | Completed | Seoul National University Hospital | 44 | 2013-06-01 | 2015-11-25 |
Showing 20 of 23. Sign in to see all of them.
Heart Defects, Congenital (2) · Anemia, Sickle Cell (1) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Bronchiolitis (1) · COVID-19 (1) · Cerebral Palsy (1) · Coronary Aneurysm (1) · Emergence Delirium (1) · Hematologic Neoplasms (1) · Hodgkin Disease (1) · Mucocutaneous Lymph Node Syndrome (1) · Nasopharyngeal Carcinoma (1) · Neoplasm Metastasis (1) · Obesity (1)
Neoplasms (5) · Pathological Conditions, Signs and Symptoms (5) · Cardiovascular Diseases (4) · Hemic and Lymphatic Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Heart Diseases (3) · Neoplasms by Histologic Type (3) · Neoplasms by Site (3) · Nervous System Diseases (3) · Pathologic Processes (3) · Signs and Symptoms (3) · Brain Diseases (2) · Cardiovascular Abnormalities (2) · Central Nervous System Diseases (2) · Congenital Abnormalities (2)
Standard of Care (3) · Drug Therapy (2) · Etoposide (2) · Nivolumab (2) · Vincristine (2) · Bendamustine Hydrochloride (1) · Betamethasone (1) · Capecitabine (1) · Carboplatin (1) · Cisplatin (1) · Cyclophosphamide (1) · Dipyrone (1) · Doxorubicin (1) · Epinephrine (1) · Exercise (1)
Cancer Institute and Hospital, Chinese Academy of Medical Sciences (3) · Assistance Publique - Hôpitaux de Paris (2) · Charite University, Berlin, Germany (2) · St. Petersburg State Pavlov Medical University (2) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Fudan University (1) · Hospital Infantil Universitario Niño Jesús, Madrid, Spain (1) · Institut Curie (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Maternal and Child Health Hospital of Hubei Province (1) · National Institutes of Health Clinical Center (CC) (1) · Seoul National University Hospital (1) · Sun Yat-sen University (1) · Tanta University (1) · The Hospital for Sick Children (1)
China (7) · France (3) · Canada (2) · Germany (2) · Russia (2) · Angola (1) · Democratic Republic of the Congo (1) · Egypt (1) · Kenya (1) · South Korea (1) · Spain (1) · Switzerland (1) · Uganda (1) · United States (1)
Sidan Li (2) · Anne-Isabelle Bertozzi-Salamon, MD (1) · Carole Coze, MD (1) · Catherine Devoldere, MD (1) · Celine De Bouyn-Icher, MD (1) · Christophe Piguet, MD (1) · Christopher A Caldarone, MD (1) · Claire Briandet, MD (1) · Claire Pluchart, MD (1) · Diane L Damiano, Ph.D. (1) · Dominique Plantaz, Prof. (1) · Estelle Thebaud, MD (1) · Frederic Millot, MD (1)
PMID 30662387, PMID 31388703, PMID 32053771, PMID 32217739, PMID 32772826, PMID 32779863, PMID 33737338, PMID 41954645
2015 (2), 2014 (1), U01HL133883 (1)