5 completed, 2 not yet recruiting, 2 recruiting, 2 unknown. 14 Phase 1, 8 Phase 2.
Follow Children: new trials by email Literature Review of Children trials Research Report on Children
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| Exploring a Natural Solution for Childhood Obesity genistein - Obesity, Children | Phase 1 / Phase 2 | Not yet recruiting | Western University | 30 | 2025-08-01 | 2025-06-24 |
| Blinatumomab in Refractory Active Childhood Systemic Lupus Erythematosus Blinatumomab 9ug - Systemic Lupus Erythematosus (SLE), Children | Phase 1 | Recruiting | Mao Jianhua | 6 | 2024-12-08 | 2025-11-28 |
| Nivolumab and DA-EPOCH-R in Pediatric Primary Mediastinal (Thymic) Large B-cell Lymphoma Nivolumab - Primary Mediastinal (Thymic) Large B-cell Lymphoma, Children | Phase 1 / Phase 2 | Enrolling by invitation | St. Petersburg State Pavlov Medical University | 22 | 2024-09-01 | 2025-03-11 |
| Effectiveness of Melissa Officinalis for the Treatment of Probable Sleep Bruxism in Children and Adolescents Melissa, Placebo - Sleep Bruxism, Adolescent | Phase 1 | Unknown | Universidade Federal do Rio de Janeiro | 42 | 2023-08-01 | 2024-01-19 |
| Inhaled Interferon α2b Treatment in Mild-to-moderate COVID-19 Infected Children Inhaled Interferon α2b, Standard of Care - COVID-19, Children | Phase 1 / Phase 2 | Terminated | Children's Hospital of Fudan University | 24 | 2022-01-01 | 2023-12-29 |
| A Study in Healthy Adult Male Participants to Learn the Way Vericiguat is Absorbed With and Without Food When Taken as a Single Dose in Liquid Form Suitable for Children Compared to a 10 Milligram (mg) Tablet That Releases the Active Substance Immediately Vericiguat (BAY1021189) - Intervention A, Vericiguat (BAY1021189) - Intervention B, Vericiguat (BAY1021189) - Intervention C - Heart Failure, Children | Phase 1 | Completed | Bayer | 36 | 2021-10-12 | 2023-02-02 |
| Pilot Trial: the Safety and Feasibility of Losartan for Pulmonary Vein Stenosis Losartan - Pulmonary Vein Stenosis, Children | Phase 1 / Phase 2 | Suspended | The Hospital for Sick Children | 40 | 2016-05-01 | 2019-07-30 |
| Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children BB-12 supplemented strawberry yogurt, Strawberry flavored yogurt - Children | Phase 1 | Completed | Georgetown University | 62 | 2013-02-01 | 2024-03-22 |
| Safety and Efficacy of Repeated Infusion of CELYVIR in Children and Adults With Metastatic and Refractory Tumors. CELYVIR - Children, Solid Tumors | Phase 1 / Phase 2 | Completed | Hospital Infantil Universitario Niño Jesús, Madrid, Spain | 20 | 2013-01-01 | 2016-02-19 |
| Laparoscopic Splenectomy in Children laparoscopic splenectomy - Laparoscopic Splenectomy, Children | Phase 1 | Completed | Tanta University | 137 | 2012-01-02 | 2021-02-23 |
| Physical, Functional and Neural Effects of Two Lower Extremity Exercise Protocols in Children With Cerebral Palsy Physical Exercise - Cerebral Palsy, Children | Phase 1 / Phase 2 | Completed | National Institutes of Health Clinical Center (CC) | 55 | 2010-03-30 | 2022-03-29 |
| Cord Blood Infusion for Type 1 Diabetes Mellitus (T1DM) Umbilical Cord Blood VITA 34 - Type 1 Diabetes, Children | Phase 1 | Unknown | Technical University of Munich | 18 | 2008-09-01 | 2013-07-23 |
Heart Defects, Congenital (2) · COVID-19 (1) · Cerebral Palsy (1) · Diabetes Mellitus, Type 1 (1) · Heart Failure (1) · Lupus Erythematosus, Systemic (1) · Neoplasm Metastasis (1) · Obesity (1) · Pediatric Obesity (1) · Sleep Bruxism (1) · Stenosis, Pulmonary Vein (1) · Temporomandibular Joint Disorders (1)
Cardiovascular Diseases (4) · Heart Diseases (3) · Autoimmune Diseases (2) · Cardiovascular Abnormalities (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Immune System Diseases (2) · Nervous System Diseases (2) · Nutritional and Metabolic Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Body Weight (1) · Brain Damage, Chronic (1) · Brain Diseases (1) · Bruxism (1) · Central Nervous System Diseases (1)
Standard of Care (3) · Cyclophosphamide (1) · Doxorubicin (1) · Etoposide (1) · Exercise (1) · Genistein (1) · Losartan (1) · Nivolumab (1) · Prednisolone (1) · Rituximab (1) · Vincristine (1) · blinatumomab (1) · lemon balm leaf extract (1) · vericiguat (1)
Charite University, Berlin, Germany (2) · Bayer (1) · Children's Hospital of Fudan University (1) · Georgetown University (1) · Hospital Infantil Universitario Niño Jesús, Madrid, Spain (1) · Mao Jianhua (1) · National Institutes of Health Clinical Center (CC) (1) · St. Petersburg State Pavlov Medical University (1) · Tanta University (1) · Technical University of Munich (1) · The Hospital for Sick Children (1) · Universidade Federal do Rio de Janeiro (1) · Western University (1)
Germany (4) · China (2) · United States (2) · Brazil (1) · Canada (1) · Russia (1) · Spain (1)
Christopher A Caldarone, MD (1) · Daniel J Merenstein, MD (1) · Diane L Damiano, Ph.D. (1) · Jianhua Mao, PhD, MD (1) · Lucianne Cople Maia, Phd (1) · Ludmila Zubarovskaya (1) · Marina Ybarra, MD, MSc (1) · Natalya Myakova (1)