28 completed, 5 withdrawn, 4 terminated, 3 not yet recruiting. 17 Phase 4, 10 Not applicable, 9 Phase 3, 5 Phase 2, 3 Phase 1.
Follow Dipyrone: new trials by email Literature Review of Dipyrone trials Research Report on Dipyrone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management Metamizole, Ibuprofen, Placebo - Cancer Pain, Cancer Palliative Care | Phase 3 | Not yet recruiting | University Hospital, Basel, Switzerland | 318 | 2026-10-01 | 2026-08-19 |
| Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain Canadá, Canadá placebo, Dipyrone - Pain, Chronic | Phase 2 | Withdrawn | EMS | 2026-09-01 | 2023-09-08 | |
| Study Protocol: Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs metamizole - Oncologic Diseases, Coagulation Defect | Not applicable | Recruiting | Rambam Health Care Campus | 30 | 2025-11-01 | 2026-02-03 |
| Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children The initial pain assessment, Drug administration according to protocol (paracetamol + ibuprofen OR paracetamol + metamizol), The effectiveness of the treatment - Pancreatitis, Acute, Pain, Acute | Phase 4 | Recruiting | Medical University of Warsaw | 78 | 2025-09-01 | 2025-08-24 |
| Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT) Acetaminophen, dipyrone - Intrapartum Fever, Chorioamnionitis | Phase 4 | Not yet recruiting | Wolfson Medical Center | 140 | 2025-08-01 | 2025-07-03 |
| Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. time interval between ESWL and ERCP is 12h, time interval between ESWL and ERCP is greater than 12h, morphine, buprenorphine, pethidine, tramaldol, metamizole and acetylsalicylacid (Analgesics) - Pancreatitis, Chronic | Not applicable | Completed | Changhai Hospital | 220 | 2025-03-12 | 2025-11-19 |
| Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery Spinal Anesthesia (bupivacaine), Postoperative pain management with acetaminophen, PCA IV Oxycodone - Analgesics, Opioid, Anesthesia, Spinal | Phase 4 | Recruiting | Medical University of Silesia | 120 | 2025-03-04 | 2026-02-12 |
| Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars DIT112, DIPYRONE, TRAMADOL - Moderate Pain, Severe Pain | Phase 3 | Not yet recruiting | EMS | 252 | 2025-02-15 | 2024-02-20 |
| Fixed Dose Combination of COdeine + DIpyrone to Mitigate Moderate to Intense Pain Post-impacted Third Lower Molar Extraction FDC of codeine 30 mg/dipyrone 500 mg, Tylex - Pain | Phase 3 | Completed | Eurofarma Laboratorios S.A. | 288 | 2023-11-08 | 2026-10-26 |
| Fixed Combination of Dipyrone and Codeine for Controlling Pain After Pelvic-abdominal Surgery Fixed dose combination Dipyrone and Codeine, Dipyrone, Codeine - Pain, Postoperative | Phase 3 | Completed | Brazilian Clinical Research Institute | 491 | 2023-03-16 | 2026-05-11 |
| Efficacy and Safety of Tiradentes Association in the Treatment of Acute Pain TIRADENTES ASSOCIATION, DIPYRONE, TRAMADOL - Acute Pain | Phase 2 | Withdrawn | EMS | 2023-03-01 | 2023-09-08 | |
| Ibuprofen vs Dipyrone After C-section in Preeclampsia medication 1, medication 2 - Preeclampsia | Phase 4 | Completed | Instituto Materno Infantil Prof. Fernando Figueira | 74 | 2022-10-15 | 2023-06-09 |
| Evaluation of the Added Value of Metamizole to Standard Postoperative Treatment After Ambulant Shoulder Surgery Metamizole, Placebo - Postoperative Pain, Analgesia | Not applicable | Completed | Jessa Hospital | 110 | 2021-02-26 | 2023-01-06 |
| Postoperative Pain in Scheduled Craniotomy Metamizole - Pain, Postoperative, Craniotomy | Completed | Hospital Universitario de Gran Canaria Doctor Negrín | 73 | 2021-02-24 | 2021-08-18 | |
| Inhibition Metamizole 2020 Novalgin - Drug-drug Interaction | Phase 1 | Completed | University Hospital, Basel, Switzerland | 12 | 2020-04-29 | 2020-11-09 |
| Efficacy of Metamizole Versus Ibuprofen and a Short Educational Intervention Versus Standard Care in Acute Low Back Pain Metamizole Sodium, Ibuprofen 600 mg, Patient education - Low Back Pain | Phase 4 | Unknown | Insel Gruppe AG, University Hospital Bern | 120 | 2019-12-15 | 2024-02-07 |
| Evaluation of the Added Value of Metamizole to Standard Post-operative Treatment After Ambulant Surgery Metamizole, Placebo oral tablet - Analgesia, Surgery | Not applicable | Completed | Jessa Hospital | 110 | 2019-11-28 | 2022-02-08 |
| Migraine Abortive Treatment Ibuprofen - Migraine Disorders | Unknown | Bnai Zion Medical Center | 50 | 2019-09-03 | 2021-09-17 | |
| Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia lidocaine 10mg/ml, Placebo, Metamizole - Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma | Phase 4 | Completed | Łukasz Krzych | 87 | 2019-01-29 | 2022-12-21 |
| Pharmacokinetic Interactions of Metamizole (Dipyrone) in Healthy Subjects Metamizole - Inhibition, Induction | Phase 1 | Completed | University Hospital, Basel, Switzerland | 12 | 2018-09-04 | 2019-06-20 |
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Pain, Postoperative (14) · Agnosia (11) · Pain (7) · Neuralgia (4) · Acute Pain (3) · Fever (2) · Inhibition, Psychological (2) · Migraine Disorders (2) · Postoperative Nausea and Vomiting (2) · Acute Kidney Injury (1) · Anxiety Disorders (1) · Aortic Aneurysm, Abdominal (1) · Cancer Pain (1) · Chorioamnionitis (1) · Chronic Pain (1)
University Hospital, Basel, Switzerland (5) · Medical University of Silesia (4) · Boehringer Ingelheim (3) · EMS (3) · Jessa Hospital (2) · Medical University of Lublin (2) · Wolfson Medical Center (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Barzilai Medical Center (1) · Baskent University (1) · Bnai Zion Medical Center (1) · Brazilian Clinical Research Institute (1) · Changhai Hospital (1) · Eurofarma Laboratorios S.A. (1) · Hadassah Medical Organization (1)
Poland (9) · Switzerland (7) · Israel (6) · Brazil (4) · Belgium (2) · China (1) · Czechia (1) · Germany (1) · Hungary (1) · Netherlands (1) · Spain (1) · Turkey (Türkiye) (1)
Albert Grinshpun (1) · Christoph Maier, Professor (1) · Christopher Boehlke, Prof. Dr. (1) · Emine A Salviz, MD (1) · Ilia Kleiner, MD (1) · Manuel Duran, MD, PhD (1) · Manuel Haschke, PD (1) · Marc Pfister, Professor (1) · Maria M. Wertli, MD PhD (1) · Markus Hollmann, MD, PhD, PhD (1) · Matej Jenko (1) · Matthias Schmauss, MD (1)
PMID 25032676, PMID 11756886, PMID 23471754, PMID 24012235, PMID 24535604, PMID 10486687, PMID 10794256, PMID 10825328, PMID 11812698, PMID 12355695, PMID 12567343, PMID 15288990, PMID 16703549, PMID 17023279, PMID 17197840, PMID 17392852, PMID 18042892, PMID 19898665, PMID 22055006, PMID 22412772, PMID 22678319, PMID 24030782, PMID 24144215, PMID 24404359, PMID 25582785, PMID 27177956, PMID 29746911, PMID 31388703, PMID 33238043, PMID 33345816, PMID 33800559, PMID 36632758, PMID 38714924, PMID 7758252
2015 (2), 2018 (2), 2019 (1)