9 completed, 1 terminated, 1 withdrawn. 11 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 9, Terminated 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Blepharitis: new trials by email Literature Review of Blepharitis trials Research Report on Blepharitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 3 Study to Evaluate the Efficacy and Safety of Pimecrolimus 0.3% Ophthalmic Ointment Pimecrolimus 0.3% Ophthalmic Ointment, Placebo Ophthalmic Ointment - Blepharitis | Phase 3 | Terminated | Famy Life Sciences, a Viatris Company | 477 | 2024-04-22 | 2026-01-07 |
| Trial to Evaluate the Efficacy and Safety of TP-03, LIBRA Study Lotilaner, Vehicle Control - Blepharitis | Phase 3 | Completed | LianBio LLC | 163 | 2022-10-23 | 2024-05-21 |
| Trial to Evaluate the Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis TP-03, TP-03 Vehicle - Blepharitis | Phase 3 | Completed | Tarsus Pharmaceuticals, Inc. | 412 | 2021-04-29 | 2023-12-21 |
| Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis TP-03, 0.25%, TP-03 Vehicle - Blepharitis | Phase 2 / Phase 3 | Completed | Tarsus Pharmaceuticals, Inc. | 421 | 2020-09-09 | 2023-12-21 |
| Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Ivermectin 0.1% Metronidazole 1%, None intervention - Chronic Blepharitis | Phase 3 | Completed | Universidad Nacional de Colombia | 60 | 2014-10-01 | 2021-05-06 |
| Antibiotic Steroid Combination Compared With Individual Administration in the in the Treatment of Ocular Inflammation and Infection azithromycin 1.5%/Loteprednol 0,5% + placebo, azithromycin 1.5% + Loteprednol 0,5% (separately) - Ocular Inflammation, Infection Associated Blepharitis | Phase 3 | Withdrawn | Adapt Produtos Oftalmológicos Ltda. | 2012-12-01 | 2014-12-11 | |
| Efficacy and Safety Study of a Steroid/Antibiotic Combination Eyedrop to Treat Non-Bacterial Blepharitis ISV-502 (1.0% azithromycin and 0.1% dexamethasone combined), Azasite, Dexamethasone - Blepharitis | Phase 3 | Completed | Sun Pharmaceutical Industries Limited | 917 | 2011-10-01 | 2021-11-19 |
| A Study to Evaluate the Clinical Efficacy and Safety of Tobradex® ST Compared to Azasite® in the Treatment of Subjects With Moderate to Severe Chronic Blepharitis Tobradex ST, Azasite - Blepharitis | Phase 3 | Completed | Alcon Research | 122 | 2010-04-01 | 2012-06-11 |
| Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis Loteprednol and tobramycin, Tobramycin and dexamethasone - Conjunctivitis, Keratitis | Phase 3 | Completed | Bausch & Lomb Incorporated | 357 | 2009-10-01 | 2012-02-28 |
| Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes Systane Ultra eyedrops, Refresh eye drops - Xerophthalmia, Blepharitis | Phase 3 | Completed | Louis Tong | 30 | 2009-07-01 | 2011-10-07 |
| Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis Moxifloxacin and Dexamethasone combined, Moxifloxacin, Dexamethasone - Blepharitis, Conjunctivitis | Phase 3 | Completed | Federal University of São Paulo | 100 | 2008-08-01 | 2011-06-22 |
Conjunctivitis (3) · Keratitis (3) · Conjunctivitis, Bacterial (1) · Eye Infections (1) · Xerophthalmia (1)
Eye Diseases (11) · Eyelid Diseases (11) · Conjunctival Diseases (4) · Corneal Diseases (3) · Infections (2) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Dry Eye Syndromes (1) · Eye Infections (1) · Eye Infections, Bacterial (1) · Lacrimal Apparatus Diseases (1)
Azithromycin (3) · Dexamethasone (3) · Tobramycin, Dexamethasone Drug Combination (2) · 22,23-dihydroavermectin B(1)a (1) · Ivermectin (1) · Loteprednol Etabonate (1) · Moxifloxacin (1) · Tobramycin (1) · avermectin H2B1b (1) · lotilaner (1) · methylacetylene (1) · pimecrolimus (1)
Tarsus Pharmaceuticals, Inc. (2) · Adapt Produtos Oftalmológicos Ltda. (1) · Alcon Research (1) · Bausch & Lomb Incorporated (1) · Famy Life Sciences, a Viatris Company (1) · Federal University of São Paulo (1) · LianBio LLC (1) · Louis Tong (1) · Sun Pharmaceutical Industries Limited (1) · Universidad Nacional de Colombia (1)
United States (5) · Brazil (2) · Singapore (2) · China (1) · Colombia (1)
David Wirta, MD (1) · Esther Chu (1) · John Meyer, MD (1) · Louis Tong, FRCS, MD (1) · Marian Macsai, MD (1) · Rubens Belfort Jr., MD (1) · Rubens Belfort, MD (1) · Zuguo Liu, M.D (1)
PMID 21138337, PMID 22256909, PMID 29325546, PMID 35965392, PMID 37285925