3 recruiting. 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 1 | Recruiting 1 |
Follow APOE-4 Positive: new trials by email Literature Review of APOE-4 Positive trials Research Report on APOE-4 Positive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Sirolimus on Asymptomatic ApoE4 Carriers Sirolimus (rapamycin), Placebo - Genetic Predisposition to Disease, Healthy Volunteer | Phase 1 | Recruiting | University of Missouri-Columbia | 225 | 2026-12-01 | 2026-10-05 |
| Predicting Pre-dementia Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD) | Recruiting | Prevention Research Consortium Corp. | 100 | 2026-11-15 | 2026-09-22 | |
| Retinal Imaging in Neurodegenerative Disease Retinal and Choroidal Imaging - Alzheimer's Disease, Mild Cognitive Impairment | Recruiting | Duke University | 2000 | 2017-07-20 | 2026-02-04 |
Alzheimer Disease (2) · Cognitive Dysfunction (2) · Amyotrophic Lateral Sclerosis (1) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Down Syndrome (1) · Frontotemporal Dementia (1) · Genetic Predisposition to Disease (1) · Genetic Risk Score (1) · Huntington Disease (1) · Lewy Body Disease (1) · Multiple Sclerosis (1) · Parkinson Disease (1) · Stress Disorders, Post-Traumatic (1)
Brain Diseases (2) · Central Nervous System Diseases (2) · Cognition Disorders (2) · Dementia (2) · Disease Attributes (2) · Disease Susceptibility (2) · Mental Disorders (2) · Nervous System Diseases (2) · Neurocognitive Disorders (2) · Neurodegenerative Diseases (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Tauopathies (2) · Abnormalities, Multiple (1) · Autoimmune Diseases (1)
Sirolimus (1)
Duke University (1) · Prevention Research Consortium Corp. (1) · University of Missouri-Columbia (1)
United States (3)
Ai-Ling Lin, PhD (1) · Dilraj Grewal, MD (1) · Foster Carr, MD (1) · Sharon Fekrat, MD FACS FASRS (1)