20 recruiting, 10 not yet recruiting, 9 unknown, 6 completed. 22 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Recruiting 12, Active not recruiting 3, Not yet recruiting 3, Unknown 2, Completed 1, Enrolling by invitation 1 |
| Phase 4 | 2 | Active not recruiting 1, Recruiting 1 |
Follow Genetic Risk Score: new trials by email Literature Review of Genetic Risk Score trials Research Report on Genetic Risk Score
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease Polygenic risk score - Coronary Heart Disease | Not yet recruiting | Medical College of Wisconsin | 200 | 2027-06-01 | 2026-05-04 | |
| Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx) - Heart Failure With Reduced Ejection Fraction | Phase 4 | Recruiting | University of Michigan | 100 | 2026-12-01 | 2026-10-15 |
| Predicting Pre-dementia Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD) | Recruiting | Prevention Research Consortium Corp. | 100 | 2026-11-15 | 2026-09-22 | |
| Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology Type 2 Diabetes Mellitus (T2DM), Chronic Pancreatitis | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 440 | 2026-09-01 | 2026-06-26 | |
| Genetic Architecture of Natriuretic Peptides and Blood Pressure Response Low Salt Diet, High Salt Diet, Saline Infusion - Hypertension (HTN), Cardiometabolic Diseases | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-09-01 | 2026-03-10 |
| Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool No Intervention: Observational Cohort - Optic Neuritis, Multiple Sclerosis | Not yet recruiting | King's College London | 180 | 2026-09-01 | 2026-07-15 | |
| Non-Invasive Diagnostic Panel for MASLD in Children With Obesity Non-Invasive Multi-Parameter Diagnostic Panel - Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity | Not yet recruiting | Kayseri City Hospital | 180 | 2026-07-01 | 2026-07-30 | |
| Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3) Coronary Artery Disease, Atherosclerosis | Enrolling by invitation | Radboud University Medical Center | 250 | 2026-05-31 | 2026-08-13 | |
| Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. Semaglutide or Tirzepatide - Obesity (Disorder), Anti-obesity Agents | Recruiting | National and Kapodistrian University of Athens | 220 | 2026-04-22 | 2026-07-10 | |
| Study of a Polygenic Risk Score to Predict the Risk of Pancreatic Ductal Adenocarcinoma Blood sample collection - Pancreatic Ductal Adenocarcinoma (mPDAC) | Not applicable | Not yet recruiting | Catholic University of the Sacred Heart | 1140 | 2026-04-01 | 2026-04-08 |
| DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk Scores Wearable Electronic Devices, Polygenic Risk Score | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 10 | 2026-02-01 | 2026-01-23 | |
| Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study Autism Spectrum Disorder (ASD) | Not yet recruiting | Research and Treatment Society of Genetic Disorders | 3000 | 2025-12-27 | 2024-10-29 | |
| Genetic Risk Score of Type 1 Diabetes Mellitus for Progression to Insulin in Diabetic Patients Lack of Predictive Value: a Multicenter Nested Case-control Study Diabetes Mellitus, Diabetes Mellitus, Type 1 | Recruiting | Second Xiangya Hospital of Central South University | 2950 | 2025-10-27 | 2026-06-02 | |
| Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health Immediate disclosure of CAD PRS results, Deferred Disclosure of CAD PRS results - Coronary Artery Disease | Not applicable | Recruiting | Massachusetts General Hospital | 500 | 2025-10-15 | 2026-03-23 |
| Better4All Personalized Intervention Personalized lifestyle recommendations based on artificial intelligence (AI) and polygenic risk scores (PRS), Standard care: lifestyle counselling, healthy eating leaflet, and hyocaloric diet targeting ≥5% weight loss in 6 months. - Obesity Prevention | Not applicable | Not yet recruiting | Harokopio University | 1022 | 2025-10-01 | 2025-05-30 |
| Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure Regular Care, SBP PRS Dissemination - Hypertension, Atherosclerotic Cardiovascular Disease | Not applicable | Recruiting | University of Alabama at Birmingham | 300 | 2025-08-01 | 2026-10-09 |
| Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations Polygenic Risk Score for Coronary Artery Disease (PRS-CAD), Standardized Risk Communication Tool (SCORE2) - Primary Prevention of Cardiovascular Disease | Not applicable | Active not recruiting | University of Bern | 205 | 2025-07-08 | 2026-06-30 |
| Implementing Polygenic Risk Scores for Breast Cancer Prevention: a Feasibility Study Clinical pathway for breast cancer prevention based on PRS-integrated CanRisk assessment - Breast Cancer | Not applicable | Recruiting | Catholic University of the Sacred Heart | 100 | 2025-06-06 | 2026-08-03 |
| The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study). The i4i PRODICT® test., Prostate cancer screening, MRI Scan - Prostate Cancer | Recruiting | Institute of Cancer Research, United Kingdom | 1000 | 2025-06-02 | 2026-02-04 | |
| Personalised HeartCare: Poligenic Risk Scores Disclosure for Cardiovascular Prevention The result of the Polygenic Risk Score will be communicated to the patient with the aim of encouraging a change in behavior - Cardiovascular Diseases | Not applicable | Recruiting | Catholic University of the Sacred Heart | 650 | 2025-06-01 | 2026-02-20 |
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Coronary Artery Disease (9) · Genetic Predisposition to Disease (8) · Cardiovascular Diseases (6) · Atherosclerosis (5) · Breast Neoplasms (5) · Diabetes Mellitus, Type 2 (5) · Prostatic Neoplasms (5) · Coronary Disease (4) · Diabetes Mellitus, Type 1 (4) · Obesity (4) · Atrial Fibrillation (2) · Hypertension (2) · Pancreatic Neoplasms (2) · Rare Diseases (2)
Disease Attributes (52) · Disease Susceptibility (52) · Pathologic Processes (52) · Pathological Conditions, Signs and Symptoms (52) · Genetic Predisposition to Disease (44) · Nutritional and Metabolic Diseases (15) · Cardiovascular Diseases (14) · Neoplasms (14) · Neoplasms by Site (14) · Vascular Diseases (14) · Arterial Occlusive Diseases (11) · Arteriosclerosis (11) · Endocrine System Diseases (11) · Heart Diseases (11) · Metabolic Diseases (11)
Biopsy (1) · Critical Pathways (1) · Diet, Sodium-Restricted (1) · Ethanol (1) · Hydroxymethylglutaryl-CoA Reductase Inhibitors (1) · Magnetic Resonance Spectroscopy (1) · Metoprolol (1) · Pharmacogenomic Testing (1) · Rosuvastatin Calcium (1) · Tirzepatide (1) · Wearable Electronic Devices (1) · semaglutide (1)
Catholic University of the Sacred Heart (5) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Harokopio University (2) · Massachusetts General Hospital (2) · Second Xiangya Hospital of Central South University (2) · University Hospital Tuebingen (2) · University of Alabama at Birmingham (2) · VA Office of Research and Development (2) · AHEPA University Hospital (1) · Adam S. Kibel, MD (1) · Alar Irs (1) · Ambry Genetics (1) · Aristotle University Of Thessaloniki (1) · Boston VA Research Institute, Inc. (1) · D'Or Institute for Research and Education (1)
United States (16) · Italy (7) · Greece (5) · Estonia (3) · Spain (3) · United Kingdom (3) · Cyprus (2) · France (2) · Germany (2) · Poland (2) · Portugal (2) · Sweden (2) · Switzerland (2) · Turkey (Türkiye) (2) · Brazil (1)
Pankaj Arora, MD, FAHA (2) · Yannis Manios, Professor (2) · Adam S Kibel, MD, MHCM (1) · Ali Torabi, MD.,Ph.D. (1) · Barbara Levy, MD (1) · Brigette Tippin-Davis, PhD (1) · Charalambos Karvounis, MD, PhD (1) · Danielle Dick, PhD (1) · Dawn M. Bravata, MD (1) · Deepak Voora, MD (1) · Eduardo S Salas, MD, PhD (1)
PMID 15741351, PMID 16415884, PMID 16775236, PMID 17434869, PMID 18820647, PMID 19268270, PMID 19585618, PMID 20624171, PMID 20808246, PMID 20888433, PMID 21274322, PMID 23555274, PMID 23592667, PMID 23840612, PMID 24566154, PMID 25410576, PMID 25471927, PMID 25673413, PMID 26147752, PMID 26511519, PMID 26512983, PMID 27222386, PMID 27560662, PMID 28107283, PMID 28144819, PMID 28450347, PMID 28718913, PMID 30104762, PMID 30124842, PMID 30267166, PMID 30281874, PMID 30772217, PMID 31030201, PMID 31255652, PMID 31584199, PMID 32020770, PMID 32188600, PMID 32190914, PMID 32588423, PMID 32777176, PMID 33002439, PMID 33567185, PMID 33991635, PMID 34103005, PMID 35312185, PMID 35658024, PMID 35736008, PMID 35949720, PMID 36506445, PMID 36849122
I01CX002635 (1), I01HX003477 (1), R01HL164629 (1), R01HL176882 (1), R01HL178410 (1), U01CA268810 (1)