14 completed, 5 active not recruiting, 5 recruiting, 4 unknown. 18 Phase 2, 6 Not applicable, 6 Phase 3.
Follow Anal Canal Carcinoma: new trials by email Literature Review of Anal Canal Carcinoma trials Research Report on Anal Canal Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study Assessment of sexual quality of life - Pelvic Cancer, Anal Cancer | Not applicable | Not yet recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 42 | 2026-04-02 | 2026-04-13 |
| Screening for Anal Cancer and Precancer in Women With HIV (SANCA) anal HPV screening - Anal Canal Cancer | Not applicable | Not yet recruiting | Karolinska Institutet | 1000 | 2025-09-01 | 2025-07-10 |
| IMRT Versus IMPT With Concurrent Chemotherapy for Locally Advanced Anal Canal Cancer IMPT (Intensity Modulated Proton Therapy), IMRT (Intensity Modulated Radiation Therapy) - Malignant Neoplasm of Anal Canal | Not applicable | Recruiting | Tata Memorial Centre | 108 | 2025-03-18 | 2025-04-08 |
| Dynamic ctDNA Assessment in Cervical and Anal Canal Tumors: Optimizing Follow-up and Clinical Outcomes ctDNA test, Pembrolizumab - HPV-Related Carcinoma, Uterine Cervical Cancer | Phase 2 | Recruiting | Instituto do Cancer do Estado de São Paulo | 150 | 2025-03-14 | 2025-12-24 |
| Inguinal Node Sparing Radiotherapy For Patients With Early Stage Anal Cancer chemo-radiation treatment - Anal Canal Cancer | Phase 2 | Recruiting | AHS Cancer Control Alberta | 45 | 2023-05-11 | 2025-10-02 |
| Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients PD-1 inhibitor, concurrent chemoradiotherapy - Anal Canal Cancer Stage III, Anal Squamous Cell Carcinoma | Phase 3 | Unknown | Sixth Affiliated Hospital, Sun Yat-sen University | 102 | 2022-05-07 | 2022-05-16 |
| PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy for Locally Advanced SCCA Patients Toripalimab - Anal Canal Cancer, Anal Squamous Cell Carcinoma | Phase 2 | Completed | Sun Yat-sen University | 25 | 2021-10-27 | 2024-12-03 |
| EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients Carboplatin, Nivolumab, Paclitaxel - Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 205 | 2020-11-17 | 2026-10-26 |
| Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers Radiation Therapy (RT) - Stage IV Esophageal Adenocarcinoma, Stage IV Esophageal Squamous Cell Carcinoma | Not applicable | Recruiting | University of California, San Francisco | 28 | 2020-08-07 | 2026-08-14 |
| Effect of Irradiation Doses < 10 Gy and of Irradiated Bone Volume on the Variation of Blood Elements of the Complete Blood Count During and After Pelvic Irradiation Biological investigations - Prostate Carcinoma, Rectum Carcinoma | Completed | Institut de cancérologie Strasbourg Europe | 100 | 2020-08-03 | 2024-01-11 | |
| Immunomonitoring and Biomarker Research in Patients With Squamous Cell Anal Carcinoma Additional biological samples - Anal Canal Cancer | Withdrawn | Centre Hospitalier Universitaire de Besancon | 2020-04-01 | 2021-07-30 | ||
| Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL) Blood sample collection, Tumor biopsies, CT scan - Squamous Cell Carcinoma of the Head and Neck, Anal Canal Cancer | Phase 2 | Completed | Centre Hospitalier Universitaire de Besancon | 47 | 2020-02-18 | 2024-12-20 |
| Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study Biopsy, Biospecimen Collection, Capecitabine - Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma | Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 252 | 2020-01-02 | 2026-10-19 |
| "Cross" Closure for Reconstructing the Perineal Wound of Abdominoperineal Resection Traditional Closure, "Cross" closure - Rectal Cancer, Anal Canal Cancer | Not applicable | Unknown | Sixth Affiliated Hospital, Sun Yat-sen University | 346 | 2018-11-20 | 2018-11-09 |
| DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457, Durvalumab - Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive | Phase 2 | Terminated | M.D. Anderson Cancer Center | 41 | 2018-11-14 | 2024-07-09 |
| Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Biopsy Procedure, Biospecimen Collection, Colonoscopy - Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 344 | 2018-07-05 | 2026-10-26 |
| Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers FDG PET scan - Cancer of the Cervix, Vulvar Cancer | Phase 2 | Active not recruiting | Duke University | 90 | 2018-03-27 | 2026-10-22 |
| Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Capecitabine, Carboplatin, Cisplatin - Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma | Phase 2 | Unknown | ECOG-ACRIN Cancer Research Group | 91 | 2016-08-23 | 2023-06-22 |
| Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer Biospecimen Collection, Computed Tomography, Ipilimumab - Anal Canal Squamous Cell Carcinoma, Metastatic Anal Canal Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 143 | 2015-05-13 | 2026-09-22 |
| Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection Therapeutic Conventional Surgery - Anal Squamous Cell Carcinoma, HIV Infection | Phase 2 | Completed | AIDS Malignancy Consortium | 16 | 2015-04-01 | 2026-04-20 |
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Anus Neoplasms (17) · Uterine Cervical Neoplasms (5) · Vaginal Neoplasms (3) · Colorectal Neoplasms (2) · Esophageal Neoplasms (2) · Neoplasm Metastasis (2) · Rectal Neoplasms (2) · Vulvar Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Carcinoma, Hepatocellular (1) · Endometrial Neoplasms (1) · Esophageal Squamous Cell Carcinoma (1) · Gastrointestinal Neoplasms (1) · HIV Infections (1)
Neoplasms by Site (23) · Neoplasms (22) · Digestive System Diseases (21) · Digestive System Neoplasms (21) · Gastrointestinal Diseases (21) · Gastrointestinal Neoplasms (20) · Intestinal Diseases (20) · Intestinal Neoplasms (20) · Rectal Diseases (20) · Colorectal Neoplasms (18) · Anus Diseases (17) · Rectal Neoplasms (17) · Genital Diseases (7) · Urogenital Diseases (7) · Female Urogenital Diseases (6)
Fluorouracil (9) · Radiotherapy (8) · Cisplatin (7) · Mitomycin (5) · Capecitabine (4) · Magnetic Resonance Spectroscopy (4) · Radiotherapy, Intensity-Modulated (4) · Nivolumab (3) · Radiation (3) · Specimen Handling (3) · Biopsy (2) · Carboplatin (2) · Cetuximab (2) · Paclitaxel (2) · Taxes (2)
Centre Hospitalier Universitaire de Besancon (4) · ECOG-ACRIN Cancer Research Group (3) · National Cancer Institute (NCI) (3) · AHS Cancer Control Alberta (2) · AIDS Malignancy Consortium (2) · Instituto do Cancer do Estado de São Paulo (2) · Radiation Therapy Oncology Group (2) · Sixth Affiliated Hospital, Sun Yat-sen University (2) · Centre Hospitalier Universitaire Vaudois (1) · Duke University (1) · Institut Paoli-Calmettes (1) · Institut de cancérologie Strasbourg Europe (1) · Institut du Cancer de Montpellier - Val d'Aurelle (1) · Karolinska Institutet (1) · M.D. Anderson Cancer Center (1)
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Cathy Eng (3) · Joseph A. Sparano, MD (2) · Lisa A. Kachnic, MD (2) · Al B. Benson, MD, FACP (1) · Andre TC Chen, MD, PhD (1) · Christina Carlander (1) · David M. Aboulafia, MD (1) · Didier Peiffert, MD (1) · Jaffer A. Ajani, MD (1) · Jennifer A Dorth (1) · Joel E. Tepper, MD (1) · John S. MacDonald, MD (1) · Junzo Chino, MD (1) · Kurian J Joseph, MD, FRCPC (1)
PMID 18430910, PMID 20354531, PMID 20956625, PMID 23578724, PMID 28223062, PMID 28453692, PMID 30042063, PMID 31534737, PMID 8874455, PMID 15629599, PMID 17103253, PMID 18191265, PMID 19139424, PMID 19801930, PMID 20436836, PMID 20564111, PMID 21240983, PMID 21514072, PMID 23150707, PMID 23484057, PMID 24035327, PMID 25935731, PMID 27600606, PMID 27937092, PMID 28055103, PMID 28463160, PMID 28841909, PMID 29755663, PMID 29878949, PMID 30264638, PMID 31288054, PMID 32530769, PMID 35928870, PMID 41499716, PMID 4830803, PMID 8348857, PMID 9164216
U10CA180820 (4), 2014 (1), N01CM00032 (1), N01CM00038 (1), N01CM00039 (1), N01CM00071 (1), N01CM00099 (1), N01CM00100 (1), P30CA016359 (1), U01CA070019 (1), U01CA121947 (1), U10CA023318 (1), U10CA180821 (1), UM1CA186704 (1), UM1CA186712 (1)