84 completed, 28 recruiting, 16 unknown, 11 active not recruiting. 41 Not applicable, 38 Phase 1, 35 Phase 2, 18 Phase 3, 1 Early Phase 1.
Follow Vaginal Neoplasms: new trials by email Literature Review of Vaginal Neoplasms trials Research Report on Vaginal Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions Routine-care metastasis-directed radiotherapy - Cervical Cancer, Gynecologic Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 500 | 2026-10-06 | 2026-10-23 | |
| Vagina-View Safety and Imaging Feasibility Vagina-View (VV) device - Vaginal Cancer | Not applicable | Recruiting | University Health Network, Toronto | 10 | 2026-09-15 | 2026-09-17 |
| A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer Best Practice, Interview, Supportive Care - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | City of Hope Medical Center | 126 | 2026-09-09 | 2026-10-16 |
| Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer Behavioral Intervention, Educational Intervention, Internet-Based Intervention - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Not applicable | Withdrawn | City of Hope Medical Center | 2026-07-16 | 2026-02-04 | |
| Methylation Profiling in Self-Samples for Identification of (Epi)Genetic Biomarkers for Gynecological Cancers Colli-Pee 20 mL device with UCM, Evalyn Brush - Gynaecological Cancers, Ovarian Cancer | Not applicable | Recruiting | Universiteit Antwerpen | 730 | 2026-06-19 | 2026-11-06 |
| A Single-arm, Multicenter Clinical Study of Becotatug Vedotin Combined With Zimberelimab in the Treatment of Recurrent and Metastatic Cervical Cancer, Vulvar Cancer and Vaginal Cancer Becotatug Vedotin in combination with Zimberelimab - Uterine Cervical Neoplasms, Recurrent; Uterine Cervical Neoplasms, Metastatic; Vulvar Neoplasms; Vaginal Neoplasms | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 30 | 2026-06-11 | 2026-06-16 |
| Reirradiation and Total Ablative Strategies for Recurrent Gynecologic Cancer Reirradiation, Total Ablative Strategy - Recurrent Gynecologic Cancer, Recurrent Uterine Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 500 | 2026-06-11 | 2026-10-16 | |
| Quality of Life and Sexuality After Pelvic Exenteration for Gynecologic Cancer Cervical Cancers, Vaginal Cancers | Enrolling by invitation | Tampere University Hospital | 21 | 2026-05-01 | 2026-05-22 | |
| Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study Assessment of sexual quality of life - Pelvic Cancer, Anal Cancer | Not applicable | Not yet recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 42 | 2026-04-02 | 2026-04-13 |
| Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer Biospecimen Collection, Prasterone, Survey Administration - Anal Carcinoma, Cervical Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-03-12 | 2026-04-21 |
| Exploring the Effects of Hand and Foot Exercise Intervention in Older Adults With Gynecological Cancer Receiving Chemotherapy Improvement of Peripheral Neuropathy and Quality of Life hand and foot exercises - Peripheral Neuropathy, Cervical Cancer | Not applicable | Not yet recruiting | Taipei Veterans General Hospital, Taiwan | 74 | 2026-01-01 | 2026-01-23 |
| DESTINY-PANTUMOUR04 Trastuzumab deruxtecan - Adenocarcinoma (NOS), Anal Cancer | Recruiting | AstraZeneca | 100 | 2025-09-18 | 2026-09-25 | |
| E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers E7 TCR-T cells, Aldesleukin - HPV-Associated Cervical Carcinoma, HPV-Related Carcinoma | Phase 1 / Phase 2 | Recruiting | Christian Hinrichs | 15 | 2025-08-11 | 2026-10-28 |
| Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46 - Anal Carcinoma, Bladder Carcinoma | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 30 | 2025-08-01 | 2026-10-20 |
| Minimally Invasive Pelvic Exenteration in Vaginal or Cervical Cancer Recurrence Minimally invasive pelvic exenteration - Cervical Cancers, Vaginal Cancers | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 64 | 2025-07-07 | 2025-07-17 |
| Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin Belzutifan - Ovarian Cancer, Ovarian Carcinoma | Phase 2 | Recruiting | Dana-Farber Cancer Institute | 32 | 2024-12-20 | 2025-11-05 |
| Enhanced Assistance During Radiotherapy for Unmet Essential Needs Standard assistance, Enhanced assistance - Bone Cancer, Brain Cancer | Not applicable | Completed | Washington University School of Medicine | 33 | 2024-10-04 | 2025-08-26 |
| Phase 1/2 Study of Autologous SCG142 TCR T Cells in Patients With HPV16/52-positive Carcinoma SCG142, Cyclophosphamide, Fludarabine - HPV-Related Squamous Cell Carcinoma, HPV-Related Cervical Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | SCG Cell Therapy Pte. Ltd. | 66 | 2024-10-01 | 2024-07-17 |
| HPV Vaccine, Imiquimod, and Metformin Combination Trial HPV vaccine, Imiquimod, and metformin combination therapy - Cervical Carcinoma, Vaginal Carcinoma | Phase 2 | Recruiting | Baylor College of Medicine | 85 | 2024-08-23 | 2024-11-13 |
| e-Health Intervention (Day-by-Day) for the Management of Fear of Progression in Women With Stage III or IV Gynecologic Cancer: A Pilot Study Discussion, Informational Intervention, Media Intervention - Malignant Female Reproductive System Neoplasm, Stage III Cervical Cancer AJCC v8 | Not applicable | Active not recruiting | City of Hope Medical Center | 23 | 2024-07-19 | 2026-11-04 |
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Uterine Cervical Neoplasms (140) · Vulvar Neoplasms (115) · Endometrial Neoplasms (72) · Ovarian Neoplasms (58) · Fallopian Tube Neoplasms (37) · Anus Neoplasms (33) · Uterine Neoplasms (29) · Carcinoma, Ovarian Epithelial (28) · Penile Neoplasms (24) · Prostatic Neoplasms (23) · Urinary Bladder Neoplasms (22) · Breast Neoplasms (20) · Rectal Neoplasms (20) · Sarcoma (20)
Female Urogenital Diseases (158) · Female Urogenital Diseases and Pregnancy Complications (158) · Genital Diseases (158) · Genital Diseases, Female (158) · Neoplasms by Site (158) · Urogenital Diseases (158) · Vaginal Diseases (158) · Urogenital Neoplasms (157) · Genital Neoplasms, Female (150) · Uterine Diseases (148) · Uterine Cervical Diseases (140) · Neoplasms (139) · Uterine Neoplasms (119) · Vulvar Diseases (115) · Endocrine System Diseases (80)
Radiotherapy (11) · Brachytherapy (8) · Cyclophosphamide (5) · Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 (5) · Magnetic Resonance Spectroscopy (5) · Radiation (5) · fludarabine (5) · Cisplatin (4) · Surveys and Questionnaires (4) · aldesleukin (4) · 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3) · Early Intervention, Educational (3) · Methods (3) · Paclitaxel (3) · Palliative Care (3)
M.D. Anderson Cancer Center (11) · Merck Sharp & Dohme LLC (10) · National Cancer Institute (NCI) (10) · Shanghai Bovax Biotechnology Co., Ltd. (7) · Ohio State University Comprehensive Cancer Center (6) · Memorial Sloan Kettering Cancer Center (5) · Royal Marsden NHS Foundation Trust (5) · City of Hope Medical Center (4) · Dana-Farber Cancer Institute (4) · Alliance for Clinical Trials in Oncology (3) · Case Comprehensive Cancer Center (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Northwestern University (3) · Affidea Nu-med Center of Oncological DIagnostics and Therapy (2) · Beijing Health Guard Biotechnology, Inc (2)
United States (87) · China (17) · United Kingdom (11) · Canada (7) · France (6) · Italy (5) · Netherlands (4) · Belgium (3) · Germany (3) · Poland (3) · Australia (2) · Austria (2) · Finland (2) · Spain (2) · Taiwan (2)
Anne Reb (3) · Clare Shaw, Phd (3) · Allison M Quick, MD (2) · Charles Kunos (2) · Christian S Hinrichs, MD (2) · Jian Zhang, Doctor (2) · Levi S. Downs, MD (2) · Lilie L Lin (2) · Martin King, MD, PhD (2) · William P. Tew, MD (2) · Yongjiang Liu, Bachelor (2) · Akila N Viswanathan, MD, MPH (1) · Akila Viswanathan, M.D. (1)
PMID 27422279, PMID 19949018, PMID 22002018, PMID 29211620, PMID 29269325, PMID 29767739, PMID 33326342, PMID 11230468, PMID 17466514, PMID 18190952, PMID 18768432, PMID 19238149, PMID 20068553, PMID 20179219, PMID 20347480, PMID 22105720, PMID 22480131, PMID 23849695, PMID 24067488, PMID 24201015, PMID 25278227, PMID 25693011, PMID 25749310, PMID 25823737, PMID 25912208, PMID 25912475, PMID 26086587, PMID 26101366, PMID 26366475, PMID 26411885, PMID 26644527, PMID 27020837, PMID 28789851, PMID 28886907, PMID 29149611, PMID 29868473, PMID 30714987, PMID 30798790, PMID 30982556, PMID 31681600, PMID 32125711, PMID 32659510, PMID 33358206, PMID 33676783, PMID 33844623, PMID 33882792, PMID 34863145, PMID 34882500, PMID 36185311, PMID 37667847
P30CA033572 (3), P30CA043703 (3), R21CA293326 (2), U01CA062502 (2), U10CA180868 (2), 2009 (1), 2017 (1), 2023 (1), P30CA014520 (1), P30CA016087 (1), P30CA016672 (1), P30CA060553 (1), R21CA135005 (1), R21CA149675 (1), R21CA167800 (1)