24 completed, 14 unknown, 8 recruiting, 3 active not recruiting. 24 Not applicable, 10 Phase 2, 5 Phase 1, 3 Phase 3, 2 Phase 4.
Follow Alzheimer Dementia: new trials by email Literature Review of Alzheimer Dementia trials Research Report on Alzheimer Dementia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-Dose Radiotherapy for Alzheimer's Disease Low Dose Radiation Therapy - Alzheimer Dementia, Dementia | Phase 1 / Phase 2 | Recruiting | Evan Thomas | 50 | 2026-07-15 | 2026-07-09 |
| Efficacy of Lecanemab at Different Therapeutic Doses for Alzheimer's Disease (AD) in Real-World Practice Lecanemab 10 mg/kg, Lecanemab 5-10mg/kg - Alzheimer Disease (AD), Alzheimer Dementia | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 140 | 2026-04-30 | 2026-04-01 | |
| Fisetin in Mild Alzheimer's Disease Fisetin - Alzheimer s Disease, Alzheimer Dementia | Phase 2 | Completed | Sunnybrook Health Sciences Centre | 5 | 2026-01-27 | 2026-08-20 |
| Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia intermittent theta burst stimulation (iTBS), Methylphenidate (MPH) - Alzheimer s Disease, Alzheimer Dementia (AD) | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 12 | 2026-01-01 | 2025-12-12 |
| LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome Levetiracetam 500mg, Placebo - Down Syndrome, Down Syndrome (DS) | Phase 3 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 120 | 2025-12-22 | 2026-01-12 |
| The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions Probiotic Supplementation with L. reuteri - PARKINSON DISEASE (Disorder), Parkinson | Not applicable | Recruiting | University of Cambridge | 215 | 2025-11-01 | 2026-08-25 |
| Therapeutic Efficacy of Monoclonal Antibody Drugs for Alzheimer's Disease Based on PET Research Lecanemab 10 mg/kg, Conventional anti-dementia treatment group - Alzheimer Disease (AD), Alzheimer Dementia | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2025-09-01 | 2025-09-03 | |
| Clinical Study to Evaluate the Efficacy and Safety of Huperzine A Controlled-Release Tablets in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type Huperzine A Controlled-Release Tablets, Donepezil hydrochloride tablets, Huperzine A controlled-release tablets placebo; Donepezil hydrochloride tablets placebo - Alzheimer Dementia | Phase 2 / Phase 3 | Recruiting | Wanbangde Pharmaceutical Group Co., LTD | 720 | 2025-08-29 | 2026-08-17 |
| Environmental Pollutants and Neurological Disorders Cerebrovascular Disorders, Brain Tumours | Recruiting | Beijing Tiantan Hospital | 500 | 2025-08-01 | 2025-08-24 | |
| Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy Quest AD-Detect blood test - Alzheimer Dementia, Alzheimer Disease | Not applicable | Recruiting | Covenant Health, US | 30 | 2025-06-10 | 2025-10-29 |
| Statins, Cholesterol and Cognitive Decline in Alzheimer's STA 4783 - Alzheimer Dementia, Statins | Completed | Karolinska Institutet | 2000 | 2025-01-01 | 2025-05-02 | |
| Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease Allopregnanolone, Placebo - Alzheimer Dementia, Late Onset Alzheimer Disease | Phase 2 | Active not recruiting | University of Arizona | 100 | 2023-08-15 | 2026-06-30 |
| Comparison of Dual Assignment, Cadence, and Gait Speed in Alzheimer's Dementia and Healthy Geriatric Individuals evaluation - Alzheimer Dementia | Unknown | Kırıkkale University | 50 | 2023-06-01 | 2023-03-14 | |
| Innate Immunity Stimulation Via TLR9 in Early AD CpG1018, Placebo - Mild Cognitive Impairment, Alzheimer Dementia | Phase 1 | Recruiting | NYU Langone Health | 18 | 2023-03-13 | 2026-01-07 |
| Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults Cognigram, Subjective cognitive decline questionnaire (SCD-Q), blood-based biomarkers - Subjective Cognitive Decline, Alzheimer Dementia | Not applicable | Unknown | Ludwig-Maximilians - University of Munich | 500 | 2023-02-01 | 2024-01-11 |
| Medication Repurposing to Stop Cognitive Decline in Dementia No intervention - Alzheimer Dementia, Dementia Disorders | Completed | Karolinska Institutet | 100000 | 2023-01-01 | 2025-05-02 | |
| A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Dementia Algorithm, Random Match - Caregiver Stress, Dementia | Not applicable | Withdrawn | Mayo Clinic | 2022-09-01 | 2022-11-17 | |
| Association of Cognition With Functional Mobility in People With Alzheimer's Disease Alzheimer Dementia, Alzheimer's Disease | Unknown | Istanbul University - Cerrahpasa | 64 | 2021-11-01 | 2021-11-09 | |
| Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD) Electroconvulsive Therapy (ECT) - Alzheimer Dementia, Agitation,Psychomotor | Not applicable | Completed | Brent Forester | 41 | 2021-01-28 | 2026-07-30 |
| Accurate WiFi-Based Localization of Dementia Patients For Caregiver Support: Activlink insole, Activlink Phone Application - Dementia, Vascular, Alzheimer Dementia | Not applicable | Completed | University of Florida | 13 | 2021-01-27 | 2023-05-17 |
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Alzheimer Disease (58) · Dementia (18) · Cognitive Dysfunction (15) · Dementia, Vascular (5) · Lewy Body Disease (4) · Memory Disorders (4) · Neurocognitive Disorders (3) · Parkinson Disease (3) · Psychomotor Agitation (3) · Anxiety Disorders (2) · Autism Spectrum Disorder (2) · Autistic Disorder (2) · Brain Diseases (2) · Brain Injuries, Traumatic (2) · Constipation (2)
Central Nervous System Diseases (58) · Mental Disorders (57) · Nervous System Diseases (57) · Tauopathies (57) · Brain Diseases (56) · Neurodegenerative Diseases (56) · Neurocognitive Disorders (55) · Dementia (40) · Cognition Disorders (15) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Neurologic Manifestations (12) · Neurobehavioral Manifestations (11) · Basal Ganglia Diseases (7) · Behavior (7)
Levetiracetam (2) · Methylphenidate (2) · Neuropsychological Tests (2) · Pregnanolone (2) · lecanemab (2) · 1018 oligonucleotide (1) · Algorithms (1) · Diagnostic Imaging (1) · Donepezil (1) · Electroencephalography (1) · Evoked Potentials (1) · Fluorescein Angiography (1) · Hematologic Tests (1) · LY2812223 (1) · Magnetic Resonance Imaging (1)
Centre Hospitalier Princesse Grace (2) · Karolinska Institutet (2) · Mayo Clinic (2) · Prof. Dr. Dieter Willbold (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Sunnybrook Health Sciences Centre (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of Arizona (2) · Assiut University (1) · Beijing Tiantan Hospital (1) · Beth Israel Deaconess Medical Center (1) · Biomed Industries, Inc. (1) · Brent Forester (1) · Cognito Therapeutics, Inc. (1) · Columbia University (1)
United States (26) · Canada (4) · Germany (4) · China (3) · Belgium (2) · Hong Kong (2) · Spain (2) · Sweden (2) · Italy (1) · Japan (1) · Monaco (1) · New Zealand (1) · Norway (1) · South Korea (1) · Turkey (Türkiye) (1)
Michael Wolzt, MD (2) · Roberta D Brinton, PhD (2) · Alma Au, PhD (1) · Arjun Masurkar, MD (1) · Brad Manor, PhD (1) · Brent P Forester, MD, MSc (1) · Brent T Mausbach, PhD (1) · Cagri G. Besirli, MD PhD (1) · Caroline Williams-Gray, Dr. (1) · Diane Chan, MD, PhD (1) · Edward S Boyden, PhD (1) · Emery Brown, MD, PhD (1) · Evan R Hempel (1) · Evan Thomas, MD, PhD (1)
PMID 30669980, PMID 33308285, PMID 34296549, PMID 35483736, PMID 36653578, PMID 37486759, PMID 37930669, PMID 38115091, PMID 39108660, PMID 39772858, PMID 39994788, PMID 40475373, PMID 40681915, PMID 40847656, PMID 41137616, PMID 41313764, PMID 41439450, PMID 41533472, PMID 41574278, PMID 41591746, PMID 41689409, PMID 41738969, PMID 41961243, PMID 42052145, PMID 42486877, PMID 42502037
1RF1AG057547-01 (1), R01AG050440 (1), R01AG063826 (1), R21AG061728 (1), R44AG046944 (1), R44AG065088 (1), RF1AG015301 (1)