22 completed. 22 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 22 |
| Phase 2 | 7 | Completed 7 |
Follow Alcohol Dependence: new trials by email Literature Review of Alcohol Dependence trials Research Report on Alcohol Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial to Evaluate the Safety of PT150 (Formerly ORG34517) When it is Taken Concurrently With Alcohol PT150, Beverage - Alcohol Dependence, Alcohol Interaction | Phase 1 | Completed | Pop Test Oncology LLC | 10 | 2018-09-01 | 2019-08-22 |
| Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders Rapamycin, Placebo - Alcohol Use Disorder, Alcohol Dependence | Phase 1 | Completed | Medical University of South Carolina | 21 | 2018-07-12 | 2021-01-27 |
| Fish Oil vs. Placebo on Subjective Effects of Alcohol Fish Oil with ethanol and placebo ethanol infusions, Placebo with ethanol and placebo ethanol infusions - Alcohol Dependence | Phase 1 | Completed | Yale University | 17 | 2017-03-02 | 2022-09-22 |
| A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects nalmefene hydrochloride 10 mg - Alcohol Dependence | Phase 1 | Completed | Otsuka Pharmaceutical Co., Ltd. | 7 | 2016-02-01 | 2017-04-18 |
| Minocycline's Effects on Alcohol Responses in Humans Minocycline, Placebo (for Minocycline) - Alcohol Dependence | Phase 1 | Completed | Yale University | 54 | 2015-07-01 | 2020-03-09 |
| Safety and Pharmacodynamic Study of GET 73 in Alcohol Dependent GET 73, inactive ingredients capsule - Alcohol Dependence | Phase 1 / Phase 2 | Completed | Laboratorio Farmaceutico Ct S.r.l. | 25 | 2014-11-01 | 2019-04-10 |
| Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics citalopram - Alcohol Dependence | Phase 1 | Completed | VA Office of Research and Development | 31 | 2014-05-01 | 2019-07-23 |
| A Novel Compound for Alcoholism Treatment PF-05190457 - Alcoholism, Alcohol-Related Disorders | Phase 1 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 14 | 2014-01-03 | 2019-12-16 |
| Effects of Nalmefene After Single Dose on the Blood Oxygen Level Dependent (BOLD) fMRI Signal in the Ventral Striatum to Reward Responding in the Monetary Incentive Delay Task (MIDT), in Non-treatment Seeking Subjects With Alcohol Dependence Following Alcohol Challenge Nalmefene 18 mg, then placebo, Placebo, then Nalmefene 18 mg - Alcohol Dependence | Phase 1 | Completed | H. Lundbeck A/S | 22 | 2013-11-01 | 2014-11-11 |
| Carisbamate as a Potential Treatment for Alcohol Dependence Carisbamate, Placebo - Alcohol Dependence, Alcohol Abuse | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 11 | 2013-02-01 | 2021-03-02 |
| Ketamine for Depression and Alcohol Dependence Ketalar (ketamine) - Depression, Alcohol Dependence | Phase 1 | Completed | Yale University | 5 | 2012-03-01 | 2020-03-09 |
| Alcohol Counseling for Telephone Quitline Callers Practical Counseling, Alcohol Intervention Counseling - Smoking, Nicotine Dependence | Phase 1 / Phase 2 | Completed | Yale University | 1948 | 2011-01-01 | 2020-04-02 |
| A Study of Brain Receptor Occupancy in Healthy Subjects opioid receptor kappa antagonist - Alcohol Dependence | Phase 1 | Completed | Eli Lilly and Company | 13 | 2010-12-01 | 2011-05-09 |
| Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse Prazosin Tablet, Placebo Tablet - Alcohol Dependence | Phase 1 / Phase 2 | Completed | Yale University | 100 | 2009-09-01 | 2020-07-27 |
| Cognitive Behavioral Treatment to Reduce Alcohol Use Among HIV-Infected Kenyans HIV support group, CBT - Binge Drinking, Alcohol Abuse | Phase 1 | Completed | Brown University | 75 | 2009-02-01 | 2011-06-22 |
| ALK33-001: A Study of RDC-0313 Administered to Healthy Adults RDC-0313, Placebo - Alcohol Dependence | Phase 1 | Completed | Alkermes, Inc. | 16 | 2008-12-01 | 2011-08-22 |
| ALK29-002: A Study of Baclofen Formulations in Healthy Adults Baclofen IR, Baclofen ER - Alcohol Dependence | Phase 1 | Completed | Alkermes, Inc. | 16 | 2008-11-01 | 2011-08-23 |
| Combination of Naltrexone and Baclofen for Alcohol Dependence:A Pilot Study. Naltrexone, Baclofen, Placebo and Behavior Therapy - Alcohol Dependence | Phase 1 | Completed | University of North Carolina, Chapel Hill | 40 | 2007-07-01 | 2011-05-06 |
| Optimizing Pharmacotherapy for Bipolar Alcoholics Naltrexone hydrochloride, Placebo - Bipolar Disorder, Alcohol Dependence | Phase 1 / Phase 2 | Completed | University of Miami | 88 | 2006-05-01 | 2016-05-17 |
| Open Label Trial of Acamprosate in Bipolar Alcoholics Acamprosate - Alcohol Dependence, Bipolar Disorder | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 9 | 2006-04-01 | 2008-09-19 |
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Alcoholism (22) · Alcohol Drinking (4) · Substance-Related Disorders (3) · Bipolar Disorder (2) · Depression (2) · Alcohol-Related Disorders (1) · Behavior, Addictive (1) · Binge Drinking (1) · HIV Infections (1) · Impulsive Behavior (1) · Mania (1) · Smoking (1) · Tobacco Use Disorder (1) · cyclopia sequence (1)
Chemically-Induced Disorders (22) · Mental Disorders (22) · Alcohol-Related Disorders (21) · Substance-Related Disorders (19) · Behavior (7) · Drinking Behavior (4) · Behavioral Symptoms (2) · Bipolar and Related Disorders (2) · Mood Disorders (2) · Blood-Borne Infections (1) · Communicable Diseases (1) · Compulsive Behavior (1) · Genital Diseases (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1)
Ethanol (2) · Naltrexone (2) · Sugars (2) · nalmefene (2) · (11R,13S,17S)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta(a)phenanthren-3-one (1) · ALKS-33 (1) · Acamprosate (1) · Aticaprant (1) · Baclofen (1) · Behavior Therapy (1) · Beverages (1) · Citalopram (1) · Fish Oils (1) · Ketamine (1) · Minocycline (1)
Yale University (5) · Alkermes, Inc. (2) · Medical University of South Carolina (2) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2) · Baylor College of Medicine (1) · Boston Medical Center (1) · Brown University (1) · Eli Lilly and Company (1) · H. Lundbeck A/S (1) · Laboratorio Farmaceutico Ct S.r.l. (1) · Otsuka Pharmaceutical Co., Ltd. (1) · Pop Test Oncology LLC (1) · University of Miami (1) · University of North Carolina, Chapel Hill (1) · VA Office of Research and Development (1)
United States (18) · Japan (1) · Kenya (1) · United Kingdom (1)
Ismene Petrakis, M.D. (3) · Benjamin A. Toll, Ph.D. (1) · Bryan K. Tolliver, M.D., Ph.D. (1) · Evgeny Krupitsky (1) · Frederick A. Bieberdorf, MD, CPI (1) · Ihsan M Salloum, MD, MPH (1) · James C Garbutt, M.D. (1) · Jeffrey H. Samet, MD, MA, MPH (1) · Jun-ichi Hashimoto, PhD (1) · Kathleen T. Brady, M.D., Ph.D. (1) · Lorenzo Leggio, M.D. (1) · Mark D. Litt, PhD (1) · Michael Saladin, PhD (1)
PMID 18636998, PMID 21631622, PMID 25419583, PMID 25456560, PMID 27621150, PMID 28216062, PMID 28351364, PMID 31557492, PMID 33155163, PMID 33972573, PMID 36249526
K24DA000435 (1), R01AA015385 (1), R01AA020504 (1), R01CA140256 (1), R21AA014821 (1), R21AA016884 (1), R21AA023150 (1)